Genetic Diversity of Recent Infectious Bursal Disease Viruses Isolated From Vaccinated Poultry Flocks in Malaysia

Aliyu, Hayatuddeen Bako; Hair-Bejo, M.; Omar, Abdul Rahman; Ideris, Aini

doi:10.3389/fvets.2021.643976

Cited by 37 publications

(39 citation statements)

References 67 publications

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“…Such type of IBDVs have also been circulating in the neighboring countries including Pakistan [ 11 , 14 ], India [ 15 ], Bangladesh [ 38 ], Thailand, Vietnam [ 39 ], and Korea [ 18 ], and were also reported in Venezuela [ 30 ]. Recently, the widespread of nVarIBDV (A2dB1) was discovered in China [ 16 , 40 ] and also reported in Japan [ 17 ], Korea [ 18 ], and Malaysia [ 19 ] in succession. The damage caused by nVarIBDV to the poultry industry has been well documented that nVarIBDV can cause severe bursal lesions and immunosuppression [ 16 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, one virulent IBDV named HLJ0504-like strains (A3B3) are circulating in China [9][10][11][12][13], Pakistan [11,14], and India [15]. Recently, the epidemics caused by novel variant IBDV (nVarIBDV) were successively reported in China [16], Japan [17], Korea [18] and Malaysia [19]. The nVarIBDV strains were classified as Genotype A2dB1, which were genetically different from the early variant IBDV originally reported in America [8,18].…”

Section: Introductionmentioning

confidence: 99%

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Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3)

Wang

Jiang

Fan

et al. 2021

Viruses

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Infectious bursal disease virus (IBDV) is a non-enveloped, bi-segmented double-stranded RNA virus and the causative agent of a poultry immunosuppressive disease known as infectious bursal disease (IBD). The novel variant IBDV (nVarIBDV) recently posed a great threat to the development of the poultry industry. In this study, we identified a novel segment-reassortant IBDV strain, IBDV-JS19-14701 (Genotype A2dB3). Phylogenic analysis showed that Segments A and B of IBDV-JS19-14701 were derived from emerging nVarIBDV (Genotype A2dB1) and long-prevalent HLJ0504-like strains (Genotype A3B3) in China, respectively. The pathogenicity of IBDV-JS19-14701 was further evaluated via animal experiments. IBDV-JS19-14701 exhibited a similar virulence to chickens with the nVarIBDV. The identification of this reassortment event is beneficial for understanding the epidemiology of nVarIBDV and will contribute to the efficient prevention and control of IBD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3)

Wang

Jiang

Fan

et al. 2021

Viruses

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“…Serotype I viruses are pathogenic to chickens, while serotype II viruses (isolated from turkeys) are non-pathogenic to chickens. Several studies have reported the evolution of IBDV in some geographical locations worldwide with the emergence of an antigenic variant and recombinant, reassortant, and distinct strains of the virus ( Aliyu et al , 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Laboratory Diagnosis of Severe Infectious Bursal Disease in Vaccinated Chickens in Khartoum, Sudan

Omer¹,

Khalafalla²

2022

Open Vet J

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Background: Infectious Bursal Disease (IBD, Gumboro disease) has become more severe than in early outbreaks in the 1980s. The present research aims to study the epidemiology of IBD in Khartoum state and compare some commonly used laboratory techniques for diagnosis. Method: We collected epidemiological data from 30 farms that showed signs suggestive of IBD, estimated the morbidity and mortality rates, and interviewed the owners about the type and the doses of the used vaccines. We collected bursas of Fabricius for virus assays and histopathology. Samples positive in the agar gel immunodiffusion (AGID) test were inoculated onto chicken embryo fibroblast cell culture and embryonated chicken eggs. Twenty-two-day-old chicks were infected experimentally with three selected isolates, and morbidity and mortality rates were compared. Results: The results showed that 70% of outbreaks occurred between 6 and 8 weeks of age, and the mean mortality rate was 51%. Epidemiologic, clinical, gross, and histopathological findings were characteristic of the severe disease caused by the very virulent IBDvirus (vvIBDV). The farms that used intermediate or the intermediate plus vaccines had lowered mortality compared with the farms that used intermediate vaccines. The AGID was found more sensitive than the counter-immuno-electrophoresis (CIEP) since it detected 83.4% of the IBDV antigen in the samples while the CIEP detected 66.7% of the samples. The reverse transcriptase polymerase chain reaction (RT-PCR) was found to be rapid, specific, and was more sensitive detecting 100% of the tested samples. Virus isolation in embryonated eggs and cell culture was not successful. Conclusion: A vvIBDV is responsible for the recent outbreaks of the disease in Sudan, resulting in a mean high mortality rate of 51%, even in vaccinated flocks. The RT-PCR and AGID are the best methods for laboratory confirmation.

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“…The lack of an effective antigen-matched vaccine has accordingly contributed to the continued prevalence of nVarIBDV. Recently, nVarIBDV epidemics have also been reported in Japan ( 12 ), South Korea ( 13 ), and Malaysia ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020

et al. 2021

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Infectious bursal disease (IBD) is an acute and highly contagious immunosuppressive disease caused by the infectious bursal disease virus (IBDV), which seriously threatens the healthy development of the poultry industry. Since its spread to China in the early 1990s, the very virulent IBDV (vvIBDV) characterized by high lethality, has been the focus of prevention and control. However, the novel variant IBDV (nVarIBDV), which has been widely prevalent in China since 2017, has brought a new threat to the poultry industry. In this study, the prevalence of IBDV in the important poultry-raising areas of China from 2019 to 2020 was detected. Of these, 45.1% (101/224) of the samples and 61.9% (26/42) of the chicken flocks were shown to be positive for IBDV. For 50 IBDVs, the sequences of the hypervariable region of the VP2 gene in segment A and of the B-marker of the VP1 gene in segment B were analyzed. The results revealed the coexistence of a number of different IBDV genotypes, including A2dB1 (nVar, 26/50, 52.0%), A3B3 (HLJ0504-like, 15/50, 30.0%), A1B1 (classical, 1/50, 2.0%), and A8B1 (attenuated, 1/50, 2.0%). This indicated that the newly emerging nVarIBDV of A2dB1 and the persistently circulating HLJ0504-like vvIBDV of A3B3 are the two important epidemic strains. Furthermore, we established that segment reassortment has occurred among these circulating strains. This study is the first to reveal the novel epidemic characteristics of IBDV since the report of the emerging nVarIBDV of A2dB1 in China.

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Genetic Diversity of Recent Infectious Bursal Disease Viruses Isolated From Vaccinated Poultry Flocks in Malaysia

Cited by 37 publications

References 67 publications

Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3)

Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3)

Epidemiology and Laboratory Diagnosis of Severe Infectious Bursal Disease in Vaccinated Chickens in Khartoum, Sudan

Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020

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