2013
DOI: 10.1089/mdr.2012.0116
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Genetic Diversity of theftsIGene in β-Lactamase-Nonproducing Ampicillin-Resistant and β-Lactamase-Producing Amoxicillin-/Clavulanic Acid-Resistant NasopharyngealHaemophilus influenzaeStrains Isolated from Children in South Korea

Abstract: Haemophilus influenzae frequently colonizes the nasopharynx of children and adults, which can lead to a variety of infections. We investigated H. influenzae carriage in the nasopharynx of 360 children, in terms of (1) the prevalence of strains with decreased susceptibility, and (2) the presence of amino acid substitutions in PBP3. One hundred twenty-three strains were isolated (34.2%, 123/360), 122 of which were classified as nontypable H. influenzae (NTHi). Of these, β-lactamase-nonproducing ampicillin-suscep… Show more

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Cited by 30 publications
(37 citation statements)
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“…The rate of levofloxacin-resistant was 24.3% in another Japanese report [18]. In South Korea, the rate of BLNAR, BLPAR, and BLPACR were 40.2, 9, and 24.6 [19].…”
Section: Discussionmentioning
confidence: 87%
“…The rate of levofloxacin-resistant was 24.3% in another Japanese report [18]. In South Korea, the rate of BLNAR, BLPAR, and BLPACR were 40.2, 9, and 24.6 [19].…”
Section: Discussionmentioning
confidence: 87%
“…l EUCAST clinical breakpoint for categorization of susceptibility to amoxicillin-clavulanic acid (14). in several geographical regions (6,(8)(9)(10)(11), and reliable detection and susceptibility categorization of this organism have become increasingly important. Commonly used acceptance criteria are Ͼ90% essential agreement for MIC determination and Ͻ1.5% VME and Ͻ3% ME for susceptibility categorization (16).…”
Section: Discussionmentioning
confidence: 99%
“…The distinction is clinically important because high-rPBP3 strains express higher resistance to extended-spectrum cephalosporins (1,2,(4)(5)(6). Group II low-rPBP3 is the predominating genotype in Australia (7), Europe (8,9), and North America (6,10), whereas high-rPBP3 strains predominate in Japan and Korea (6,11).…”
mentioning
confidence: 99%
“…Genetically defined ␤-lactamase-negative ampicillin-resistant (gBLNAR) isolates carry either the N526K (Ubukata group II) or the R517H substitution in PBP3, while the additional substitutions S385T and/or L389F (Ubukata group III) further reduce susceptibility (3, 5-7). A range of other amino acid substitutions has been identified, but their significance is unclear (3-5, 8, 9).Whether the worldwide spread of gBLNAR isolates is caused by clonal dissemination or horizontal gene transfer is controversial (8,10,11). H. influenzae and Haemophilus haemolyticus are close relatives, (1) and putative transfer of ftsI between these two species is indicated by mosaic structures of ftsI from clinical and nasopharyngeal carriage isolates (12,13).…”
mentioning
confidence: 99%
“…Whether the worldwide spread of gBLNAR isolates is caused by clonal dissemination or horizontal gene transfer is controversial (8,10,11). H. influenzae and Haemophilus haemolyticus are close relatives, (1) and putative transfer of ftsI between these two species is indicated by mosaic structures of ftsI from clinical and nasopharyngeal carriage isolates (12,13).…”
mentioning
confidence: 99%