Genetic diversity of the JC polyomavirus (JCPyV) and mitochondrial DNA ancestry in Misiones, Argentina

Sanabria, Daiana Jimena; Mojsiejczuk, Laura; Torres, Carolina; Meyer, Alejandro; Mbayed, Viviana Andrea; Liotta, Domingo Javier; Campos, Rodolfo Héctor; Schurr, Theodore G.; Badano, Inés

doi:10.1016/j.meegid.2019.104011

Cited by 6 publications

(5 citation statements)

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“…All B2ak mitogenomes known so far derive from contemporary and ancient samples from Central Argentina (García et al, 2021). CR sequences assignable to the nested branch B2ak1 (B2 +16142 ) suggest that this lineage attains its highest frequency and internal branching diversity in Central (García, Pauro, Bailliet, Bravi, & Demarchi, 2018) and West‐Central Argentina (Motti, 2012), and that it has wider distribution into Northwest and Northeast Argentina, and in Chile (Bobillo et al, 2010; de Saint Pierre et al, 2012b, Gómez‐Carballa et al, 2016; Sanabria et al, 2019). Lineage B2 +16142 has also been reported in one of 19 individuals from the Northwest Argentina archeological site of Pampa Grande, dated to ~1300 BP (Carnese et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

Ancient mitogenomes from the Southern Pampas of Argentina reflect local differentiation and limited extra‐regional linkages after rapid initial colonization

Motti

Pauro

Scabuzzo

et al. 2023

American Journal of Biological Anthropology

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Objective This study aims to contribute to the recovery of Indigenous evolutionary history in the Southern Pampas region of Argentina through an analysis of ancient complete mitochondrial genomes. Materials and Methods We generated DNA data for nine complete mitogenomes from the Southern Pampas, dated to between 2531 and 723 cal BP. In combination with previously published ancient mitogenomes from the region and from throughout South America, we documented instances of extra‐regional lineage‐sharing, and estimated coalescent ages for local lineages using a Bayesian method with tip calibrations in a phylogenetic analysis. Results We identified a novel mitochondrial haplogroup, B2b16, and two recently defined haplogroups, A2ay and B2ak1, as well as three local haplotypes within founder haplogroups C1b and C1d. We detected lineage‐sharing with ancient and contemporary individuals from Central Argentina, but not with ancient or contemporary samples from North Patagonian or Littoral regions of Argentina, despite archeological evidence of cultural interactions with the latter regions. The estimated coalescent age of these shared lineages is ~10,000 years BP. Discussion The history of the human populations in the Southern Pampas is temporally deep, exhibiting long‐term continuity of mitogenome lineages. Additionally, the identification of highly localized mtDNA clades accords with a model of relatively rapid initial colonization of South America by Indigenous communities, followed by more local patterns of limited gene flow and genetic drift in various South American regions, including the Pampas.

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Section: Resultsmentioning

confidence: 99%

Ancient mitogenomes from the Southern Pampas of Argentina reflect local differentiation and limited extra‐regional linkages after rapid initial colonization

Motti

Pauro

Scabuzzo

et al. 2023

American Journal of Biological Anthropology

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“…The phylogenetic analysis of VP1 sequences from JCPyV‐positive samples indicated that they belonged to 2A genotype (Figure 1). The latter was an expected finding since subtype 2A is the most frequently described genotype in Native Americans [2]. In addition, in urine and environment samples obtained in Buenos Aires, Argentina, subtype 2A was the most frequently detected viral subtype [3].…”

Section: Discussionmentioning

confidence: 98%

“…Epidemiological data regarding HPyV infections in Argentina are scarce, and most of the publications on this topic are limited to specific populations or environmental samples [2,3]. Moreover, there is scarce information about infections in immunocompromised patients from this country.…”

Section: Introductionmentioning

confidence: 99%

Infection by human polyomaviruses JCPyV and BKPyV in blood donors of Argentina

et al. 2023

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Background and ObjectivesA spectrum of blood‐borne infectious agents may be transmitted through transfusion of blood components from asymptomatic donors. Despite the persistence of polyomaviruses in blood cells, no studies have been conducted in Argentina to assess the risk of transfusion infection.Materials and MethodsWe investigated BKPyV and JCPyV in 720 blood donors, using polymerase chain reaction (PCR) for a region of T antigen common to both viruses. Positive T‐antigen samples were subjected to two additional PCR assays targeting the VP1 region. Viral genotypes were characterized by phylogenetic analysis.ResultsPolyomaviruses were detected in 1.25% (9/720) of the blood samples selected; JCPyV was identified in 0.97% (7/720) and BKPyV in 0.28% (2/720) of them. Phylogenetic analysis showed that the JCPyV sequences clustered with 2A genotype and Ia of BKPyV.ConclusionThis study describes for the first time the prevalence of polyomavirus DNA in blood donors of Córdoba, Argentina. The polyomavirus DNAemia in healthy populations suggests that those viruses are present in blood components eligible for transfusion. Therefore, the epidemiological surveillance of polyomavirus in blood banks might be incorporated into haemovigilance programmes, to determine the infectious risk and implement newer interventions to ensure the safety of blood supplies, if required.

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“…Interestingly, a study showed that JCPyV-positive Africans had European mtDNAs, and given the fact that the supposed JCPyV is assumed to have European ancestry, the initial viral sequence may have been detected in European mitochondria [151]. Therefore, molecular diagnosis may not always be positive regardless of clinical manifestations giving rise to the supposed asymptomatics [152], but also, this scenario seems to bring us closer to the real answer about the existence of JCPyV!…”

Section: The Expert Opinion-demystifying Jcpyv and Pmlmentioning

confidence: 99%

John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis

Mouliou

2024

Diseases

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Progressive Multifocal Leukoencephalopathy (PML) is a possibly fatal demyelinating disease and John Cunningham Polyomavirus (JCPyV) is believed to cause this condition. The so-called JCPyV was initially reported in lymphoma and Human Immunodeficiency Virus (HIV) cases, whereas nowadays, its incidence is increasing in Multiple Sclerosis (MS) cases treated with natalizumab (Tysabri). However, there are conflicting literature data on its pathology and diagnosis, whereas some misdiagnosed reports exist, giving rise to further questions towards the topic. In reality, the so-called PML and the supposed JCPyV are not what they seem to be. In addition, novel and more frequent PML-like conditions may be reported, especially after the Coronavirus Disease 2019 (COVID-19) pandemic.

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Genetic diversity of the JC polyomavirus (JCPyV) and mitochondrial DNA ancestry in Misiones, Argentina

Cited by 6 publications

References 50 publications

Ancient mitogenomes from the Southern Pampas of Argentina reflect local differentiation and limited extra‐regional linkages after rapid initial colonization

Ancient mitogenomes from the Southern Pampas of Argentina reflect local differentiation and limited extra‐regional linkages after rapid initial colonization

Infection by human polyomaviruses JCPyV and BKPyV in blood donors of Argentina

John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis

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