2018
DOI: 10.1016/j.ttbdis.2018.05.005
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Genetic diversity of Theileria equi and Babesia caballi infecting horses of Central-Southern Italy and preliminary results of its correlation with clinical and serological status

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Cited by 35 publications
(52 citation statements)
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“…Infection of equines with different T. equi clade genotypes has been noted, with studies of naturally infected populations showing differences in the severity of clinical signs between individuals depending on the infecting genotype (Manna et al, ). Additionally, recent experimental work has shown that super‐infection with both T. equi and the newly described T. haneyi is possible, and can be maintained for many months (Sears et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…Infection of equines with different T. equi clade genotypes has been noted, with studies of naturally infected populations showing differences in the severity of clinical signs between individuals depending on the infecting genotype (Manna et al, ). Additionally, recent experimental work has shown that super‐infection with both T. equi and the newly described T. haneyi is possible, and can be maintained for many months (Sears et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…Most of the focus has been on the immunogenic ema gene family [31]. Ema-1 has been shown to be relatively conserved [32,33], and it is used in the cELISA kit for detection of exposure [34]. However, as in this study, this locus is less sensitive when used in conventional PCR and does not allow discrimination between different strains.…”
Section: Discussionmentioning
confidence: 90%
“…Thus, although the number of cases was limited, genotype A may be associated with clinical disease. Genotype A was previously isolated from horses in both endemic and non-endemic countries [5,10,31,35], it was isolated in two outbreaks in the US [36], and was found to be associated with clinical and seropositive cases in Italy [19]. Interestingly, genotype A was the predominant genotype isolated from ticks collected from horses in Israel, including in farms in which this genotype was not isolated from horses (unpublished data).…”
Section: Discussionmentioning
confidence: 92%
“…Interestingly, genotype A was the predominant genotype isolated from ticks collected from horses in Israel, including in farms in which this genotype was not isolated from horses (unpublished data). It is possible that this genotype is more adapted to the tick vector environment and encounter an active barrier at the horse stage, meaning that genotype A is more likely to lead to clinical disease, while genotypes B, C and D are more likely to result in subclinical infection [19]. With the recent concerns regarding the classification of Theileria species according to the 18S rRNA gene [6,7], it is possible that this "A genotype" is the cause of the "classic" equine theileriosis, while other genotypes may represent closely related, less pathogenic, species or subspecies.…”
Section: Discussionmentioning
confidence: 99%
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