Genetic effects and correlations between production and fertility traits and their dependency on the lactation-stage in Holstein Friesians

Strucken, Eva; Bortfeldt, Ralf; Tetens, Jens; Thaller, Georg; Brockmann, Gudrun A.

doi:10.1186/1471-2156-13-108

Cited by 31 publications

(34 citation statements)

References 58 publications

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“…This is due to the high nutritional requirements that are difficult to meet. The nutrients supplied are in the first place used for maintenance and milk production [27,28], leading to competition between milk yield and fertility [9,25], thus resulting in poorer SPC value.…”

Section: Discussionmentioning

confidence: 99%

“…High-yielding cows show a higher ability to mobilize energy reserves during the early lactation period [8,9]. This may result in metabolic changes, leading to a decrease in reproductive parameters due to functional changes of the reproductive system [10], which translate into lower conception rate and increased likelihood of pregnancy loss [11].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Some Factors on Number of Services per Conception in Dairy Cows

Siatka¹,

Sawa²,

Krężel-Czopek³

et al. 2017

J Vet Sci Technol

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The study involved 55 685 Polish Holstein-Friesian cows whose services per conception (SPC) averaged 2.2. Statistical analysis performed using the GLM procedure of SAS, showed significant differences in SPC value within different factors. The greatest changes were associated with daily milk yield of the cows; as it increased from ≤ 20 kg to >40 kg, the number of services required to conceive increased by 0.6. SPC value deteriorated also with an increasing number of cows in the herd (by 0.37) and with an increase in milk somatic cell count, being indicative of mastitis (by 0.11). The opposite situation existed for an increase in herd production level and lengthening of the interval between calving and first insemination (decrease of SPC by 0.31). It was also found that summer was the least favourable period for insemination and winter the most favourable (SPC=2.28 vs 2.16). Analysis of the results demonstrates that it is necessary and appropriate to account for these factors when aiming to improve cow fertility.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Some Factors on Number of Services per Conception in Dairy Cows

Siatka¹,

Sawa²,

Krężel-Czopek³

et al. 2017

J Vet Sci Technol

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“…With respect to “age” effects, we refer to 1st, 2nd and 3rd lactation, which differs depending on the physiological condition of the cow. During the first lactation, the mammary gland further develops, while when this endocrine system is fully established, the pathways of milk production are more effective in following lactations [25].…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, in these models, the DGAT1 SNP of the BovineSNP50K (ARS-BFGL-NGS-4939) with the lowest p-value was fitted as a fixed effect to account for the allelic dosage of the DGAT1 effect, as previously described [32]. However, accounting for DGAT1 as best known major gene for milk fat synthesis affecting milk fat content is still under discussion since it is not clear, neither from a biological nor from a statistical point of view, how its variance affects the detection of other loci [25]. Therefore, a SNP or haplotype was considered significant, if one of the p-values of model 3 or 4 was <0.05.…”

Section: Methodsmentioning

confidence: 99%

Impact of Variation at the FTO Locus on Milk Fat Yield in Holstein Dairy Cattle

et al. 2013

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This study explores the biological role of the Fat Mass and Obesity associated (FTO) gene locus on milk composition in German Holstein cattle. Since FTO controls energy homeostasis and expenditure and the FTO locus has repeatedly shown association with obesity in human studies, we tested FTO as a candidate gene in particular for milk fat yield, which represents a high amount of energy secreted during lactation. The study was performed on 2,402 bulls and 860 cows where dense milk composition data were available. Genetic information was taken from a 2 Mb region around FTO. Five SNPs and two haplotype blocks in a 725 kb region covering FTO and the neighboring genes RPGRIP1L, U6ATAC, and 5 S rRNA were associated with milk fat yield and also affected protein yield in the same direction. Interestingly, higher frequency SNP alleles and haplotypes within the FTO gene increased milk fat and protein yields by up to 2.8 and 2.2 kg per lactation, respectively, while the most frequent haplotype in the upstream block covering exon 1 of FTO to exon 15 of RPGRIP1L had opposite effects with lower fat and milk yield. Both haplotype blocks were also significant in cows. The loci accounted for about 1% of the corresponding trait variance in the population. The association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein yield. The pleiotropic effects suggest a biological function on the usage of energy resources and the control of energy balance rather than directly affecting fat and protein synthesis. The identified effect of the obesity gene locus on milk energy content suggests an impact on infant nutrition by breast feeding in humans.

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“…Although the causative gene underlying these QTL has not been functionally demonstrated, AGPAT6 has been proposed as a candidate for these effects [9]–[11]. The AGPAT6 gene represents an excellent positional candidate in this regard since, like DGAT1 , AGPAT6 plays pivotal roles in milk fat synthesis.…”

Section: Introductionmentioning

confidence: 99%

Expression Variants of the Lipogenic AGPAT6 Gene Affect Diverse Milk Composition Phenotypes in Bos taurus

et al. 2014

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Milk is composed of a complex mixture of lipids, proteins, carbohydrates and various vitamins and minerals as a source of nutrition for young mammals. The composition of milk varies between individuals, with lipid composition in particular being highly heritable. Recent reports have highlighted a region of bovine chromosome 27 harbouring variants affecting milk fat percentage and fatty acid content. We aimed to further investigate this locus in two independent cattle populations, consisting of a Holstein-Friesian x Jersey crossbreed pedigree of 711 F2 cows, and a collection of 32,530 mixed ancestry Bos taurus cows. Bayesian genome-wide association mapping using markers imputed from the Illumina BovineHD chip revealed a large quantitative trait locus (QTL) for milk fat percentage on chromosome 27, present in both populations. We also investigated a range of other milk composition phenotypes, and report additional associations at this locus for fat yield, protein percentage and yield, lactose percentage and yield, milk volume, and the proportions of numerous milk fatty acids. We then used mammary RNA sequence data from 212 lactating cows to assess the transcript abundance of genes located in the milk fat percentage QTL interval. This analysis revealed a strong eQTL for AGPAT6, demonstrating that high milk fat percentage genotype is also additively associated with increased expression of the AGPAT6 gene. Finally, we used whole genome sequence data from six F1 sires to target a panel of novel AGPAT6 locus variants for genotyping in the F2 crossbreed population. Association analysis of 58 of these variants revealed highly significant association for polymorphisms mapping to the 5′UTR exons and intron 1 of AGPAT6. Taken together, these data suggest that variants affecting the expression of AGPAT6 are causally involved in differential milk fat synthesis, with pleiotropic consequences for a diverse range of other milk components.

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Genetic effects and correlations between production and fertility traits and their dependency on the lactation-stage in Holstein Friesians

Cited by 31 publications

References 58 publications

Effect of Some Factors on Number of Services per Conception in Dairy Cows

Effect of Some Factors on Number of Services per Conception in Dairy Cows

Impact of Variation at the FTO Locus on Milk Fat Yield in Holstein Dairy Cattle

Expression Variants of the Lipogenic AGPAT6 Gene Affect Diverse Milk Composition Phenotypes in Bos taurus

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