Genetic effects of ABCG2 polymorphism on milk production traits in the Chinese Holstein cattle

Alim, M. A.; Yu, Fan; Wu, Xiaoping; Sun, Dongxiao; Zeng, Yi; Zhang, Shengli; Zhang, Qin; Lin, Liu

doi:10.1080/09712119.2013.782873

Cited by 12 publications

(11 citation statements)

References 26 publications

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“…Different genetic variants are present at bovine milk trait loci, and considerable differences in allele frequencies for these traits were observed among breeds (Cohen-Zinder et al, 2005;Komisarek et al, 2011;Alima et al, 2013;Ibeagha-Awemu et al 2016;Ozdemir et al, 2018). Consequently, marker-assisted selection based on SNPs has been used for the selection of milk production traits (Hayes et al, 2007).…”

Section: Research Articlementioning

confidence: 99%

Variation in the Genetic Effects of ABCG2, Growth Hormone and Growth Hormone Receptor Gene Polymorphisms on Milk Production Traits in Egyptian Native, Holstein and Hybrid Cattle Populations

El‐Nahas¹

2018

PVJ

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The aim of the present study was to evaluate the effect of polymorphisms in the ATP-binding cassette subfamily G member 2 (ABCG2), growth hormone (GH) and growth hormone receptor (GHR) genes on 305-day yields and milk traits in native Egyptian cattle (Baladi), Holstein Friesian cattle and hybrid cattle using DNA sequencing and Restriction Fragment Length Polymorphisms (RFLPs). A total of 148 cows were selected from the three animal populations. The ABCG2-HhaI-AA genotype was significantly associated with an increased milk lactose percentage and reduced milk yields in Baladi cows. The GH-MSP1-heterozygous genotype (GH) showed significant associations with SNF, protein and lactose percentages in the hybrid cows. Fewer TG repeats were found in the 5' untranslated region of GHR in Baladi cows, which could be used for marker-assisted selection to protect against the lower milk yields observed in this population. Additionally, GHR-MSP1-VL, can be associated with higher SNF, fat, protein and lactose percentages in hybrid cows, as well as lower milk yields in Baladi cows. We concluded that the three cattle populations have their own genetic identities in relation to genetic markers, which can be used for marker-assisted selection to improve milk traits in these three cattle populations.

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Section: Research Articlementioning

confidence: 99%

Variation in the Genetic Effects of ABCG2, Growth Hormone and Growth Hormone Receptor Gene Polymorphisms on Milk Production Traits in Egyptian Native, Holstein and Hybrid Cattle Populations

El‐Nahas¹

2018

PVJ

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“…At the same time, this suggests that g.45599A> C-C increases protein yield and percentage of protein in milk. The results suggest that the identified polymorphism may become a potential genetic marker to increase the milk yield of Chinese Holstein-Friesian cows (Alim et al 2013). Research by Mousavizadeh et al (2013) also showed the influence of ABCG2 gene polymorphism.…”

Section: Abcg2 Genementioning

confidence: 76%

“…In the studies of Alim et al (2013) individuals with CC genotype were characterized by the highest efficiency and protein content in 305-day lactations, higher by 2.65 kg and 0.04% respectively, compared to cows of AA genotype. Cows being heterozygotes of the AC genotype were characterized by intermediate values of these traits.…”

Section: Abcg2 Genementioning

confidence: 98%

Association of Polymorphism of Choosen Genes With Production Traits in Dairy Cattle

Czerniawska-Piątkowska¹,

JADWIŻAK²

2018

Folia Pomer. Univ. Technol. Stetin., Agric., Aliment., Pisc., Z

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Streszczenie. Polimorfizm genów DGAT1, ABCG2, SCD1 i PPARGC1A istotnie wpływa na wydajność mleka, tłuszczu i białka oraz skład chemiczny mleka. W zależności od rodzaju polimorfizmu powodują one zwiększenie bądź zmniejszenie wydajności mleka oraz tłuszczu i białka, a także ich zawartości w mleku. Na podstawie licznych badań można stwierdzić, iż słuszne jest genotypowanie zwierząt pod kątem polimorfizmu wybranych genów i wykorzystywanie tych informacji w programach hodowlanych w celu selekcji wspomaganej markerami, co pozwoli na rozwój populacji o najbardziej pożądanych cechach produkcyjnych.

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“…The current study provides no clear evidence of genetic conversion between ABCG2 and ABCG2-like genes (Additional file 9), which supports the hypothesis of an independent origin of ABCG2 and ABCG2-like genes. Olsen et al [22] found that the ABCG2-PKD2-SPP1 segment was located in a QTL. In the present study, the above segment was also found in some birds.…”

Section: Origin Duplication Events and Conversion Of The Abcg2 And Amentioning

confidence: 99%

“…The ABCG2 gene is located in a quantitative trait locus (QTL) in some livestock species, and mutations in ABCG2 are associated with performance and disease traits in livestock and humans [21]. For example, ABCG2 variants are likely to affect the milk yield and composition in Holstein cattle [21][22][23] and the development of gout [24] and drug resistance in human cancer cells [1,[25][26][27][28] (e.g., breast [1,27], colon [25] and liver [28] cancer cells). However, the evolutionary process and functions of the ABCG2-like gene (ABCG2 paralog and a member of the ABCG2 gene subfamily in birds) remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds

Liu

Sun

et al. 2020

BMC Evol Biol

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Background: ATP-binding cassette (ABC) transporters are involved in the active transportation of various endogenous or exogenous substances. Two ABCG2 gene subfamily members have been identified in birds. A detailed comparative study of the ABCG2 and ABCG2-like genes aid our understanding of their evolutionary history at the molecular level and provide a theoretical reference for studying the specific functions of ABCG2 and ABCG2like genes in birds. Results: We first identified 77 ABCG2/ABCG2-like gene sequences in the genomes of 41 birds. Further analysis showed that both the nucleic acid and amino acid sequences of ABCG2 and ABCG2-like genes were highly conserved and exhibited high homology in birds. However, significant differences in the N-terminal structure were found between the ABCG2 and ABCG2-like amino acid sequences. A selective pressure analysis showed that the ABCG2 and ABCG2-like genes were affected by purifying selection during the process of bird evolution. Conclusions: We believe that multiple members of the ABCG2 gene subfamily exist on chromosome 4 in the ancestors of birds. Over the long course of evolution, only the ABCG2 gene was retained on chromosome 4 in birds. The ABCG2-like gene on chromosome 6 might have originated from chromosome replication or fusion. The structural differences between the N terminus of ABCG2 protein and those of ABCG2-like proteins might lead to functional differences between the corresponding genes.

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Genetic effects of ABCG2 polymorphism on milk production traits in the Chinese Holstein cattle

Cited by 12 publications

References 26 publications

Variation in the Genetic Effects of ABCG2, Growth Hormone and Growth Hormone Receptor Gene Polymorphisms on Milk Production Traits in Egyptian Native, Holstein and Hybrid Cattle Populations

Variation in the Genetic Effects of ABCG2, Growth Hormone and Growth Hormone Receptor Gene Polymorphisms on Milk Production Traits in Egyptian Native, Holstein and Hybrid Cattle Populations

Association of Polymorphism of Choosen Genes With Production Traits in Dairy Cattle

Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds

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