Genetic Engineering In BioButanol Production And Tolerance

Rao, A. Gangagni; Sathiavelu, A.; Sathiavelu, Mythili

doi:10.1590/1678-4324-2016150612

Cited by 12 publications

(6 citation statements)

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“…Encouraged by policy measures and targets for use as transport fuel, global production of biofuels is estimated to be over 35 billion litres [35]. Recent research efforts have concentrated on applying metabolic engineering and modern genetic methods in order to develop organisms optimized for high productivity and energy value, in order to achieve their full processing capabilities [36].…”

Section: Resultsmentioning

confidence: 99%

“…For this reason, biofuels are currently pursued as a fuel alternative that can be easily applied in the short term, until other options that are harder to implement, such as hydrogen, are available. Despite biofuels being currently more expensive than fossil fuels, their production is increasing around the world.Encouraged by policy measures and targets for use as transport fuel, global production of biofuels is estimated to be over 35 billion litres [35]. Recent research efforts have concentrated on applying metabolic engineering and modern genetic methods in order to develop organisms optimized for high productivity and energy value, in order to achieve their full processing capabilities [36].…”

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Theoretical and Practical Studies on the Metabolic Engineering of Streptomyces for Production of Butanols

Doori

Hunter

2017

JMEN

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Production of biofuels is a significant technical and commercial challenge. To compete effectively with fossil fuels, the efficiency of processes that convert sustainable feedstocks to biofuel has to be improved. Ideally, the ultimate aim is a single process that degrades the renewable feedstock quickly and delivers high titers of biofuel at a price that is competitive with equivalent fuel from fossil sources. However, the microbes that are currently being investigated for biofuel production fall into two categories: those that degrade cellulosic feedstock but cannot make biofuels effectively and those that do make biofuels but are poor at degrading the cellulosic feedstock. When biofuel production is engineered into cellulose degraders, or cellulose degradation engineered into microbes with capability to produce biofuel, another factor, lignin content (a toxic component in most sustainable feedstocks), comes into play. This review considers the latent opportunity to harness Streptomyces bacteria to address this issue.Keywords: Feedstocks; Production; Butanol; Decarbonisation; Streptomyces Theoretical and Practical Studies on the Metabolic Engineering of Streptomyces for Production of Butanols 2/4Copyright: ©2017 Doori et al.Microbes make a significant contribution to the production of biofuels [6][7]. However, the yield of product by native microbes is uneconomic, which makes it necessary to develop and improve them through strategies of systems and synthetic biology [8][9]. Alcohol producers, such as Saccharomyces cervisiae which are excellent at fermenting sugars to alcohols, cannot digest lignocelluloses. A combination of pretreatment [10,11] of the feedstock and genetic engineering of the yeast, results in utilization of the cellulose and hemi-cellulose, but hydrolysis products of lignin are toxic to yeast. Other natural alcohol producers, e,g. the bacterium Zymomonas mobilis, have similar problems of lignin toxicity.Therefore, the choice of organism(s) should be based on those that have a proven ability to degrade lignocelluloses, be impervious to toxicity of lignin and be comparatively fast growing. They should also be amenable to genetic manipulation and ideally have been used industrially for large scale fermentation. This mini-review considers the latent potential of Streptomyces bacteria to make a significant contribution to biofuel production, using biobutanol as an example. Although notable for antibiotic production, these resilient bacteria seem to have been overlooked in the context of biofuel production. Review of the Literature and DiscussionThe soil Actinomycetes are notable as being adopted by industry, particularly for large-scale production of antibiotics. Most actinomycetes do not normally produce significant quantities of alcohols. However, introduction of the key enzymes into strains can stimulate alcohol (ethanol) production. The critical enzymes are pyruvate decarboxylase and alcohol dehydrogenase. Corynebacterium glutamicum [12,13] and several Streptomyces sp. [14] have bee...

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Theoretical and Practical Studies on the Metabolic Engineering of Streptomyces for Production of Butanols

Doori

Hunter

2017

JMEN

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“…Because of these problems, the production of biobutanol on a commercial scale has remained uneconomical. 83,84 Biobutanol production is biphasic fermentation where acetic and butyric acids are produced during the acidogenic phase followed by their conversion into acetone and butanol (solventogenic phase). At the end of the fermentation, cell mass and other suspended solids removed by centrifugation can be sold as cattle feed.…”

Section: Advanced Fermentation and Downstream Processingmentioning

confidence: 99%

“…are some of the example of genetically modified butanol producer organisms. 84,88,89 8 | STATUS OF BUTANOL PRODUCTION Acetone-butanol-ethanol (ABE) fermentation by C. acetobutylicum is one of the oldest known industrial fermentation processes and ranked second only to ethanol fermentation by yeast in its scale of production. However, since 1950's industrial ABE fermentation declined continuously, almost all butanol is now produced via petrochemical routes.…”

Section: Metabolic Engineering For Increased Butanol Productionmentioning

confidence: 99%

Biobutanol: New era of biofuels

et al. 2018

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Summary Global energy demands are primarily met through non‐renewable sources such as coal, natural gas, and oil. However, the scarcity and rising prices of fossil fuels, coupled with the unprecedented environmental problems, lead the researchers to find out a microbial alternative to address these issues. Biofuel has emerged as an attractive solution which can be effectively used in the current scenario. Among the probable list of alternates, biobutanol is an important renewable source of biofuel which can be easily accommodated in existing fuels due to its better performance and other advantages over other biofuels. Bio‐butanol can be efficiently produced from industrial, agricultural, and domestic waste material through microbial fermentation. Industries produce a huge amount of waste, and if not managed properly, it can be a major cause of pollution related to soil, water, and air. Microorganisms such as Escherichia coli, Clostridium acetobutylicum, Bacillus subtilis, Clostridium beijerinkckii, Pseudomonas putida, and Saccharomyces cerevisiae, etc. can utilize carbohydrate rich waste material to produce bio‐butanol through aerobic and anaerobic fermentation. Production of biobutanol from industrial wastes not only provides an ideal, eco‐friendly clean/green energy source but also has potential to address the global issues of pollution, global warming, and greenhouse effect etc. to a greater extent. The issues such as global status of bio‐energy, source of butanol production, purification, extraction, and strategies to enhance biobutanol yield through biotechnological interventions have been discussed in the present paper.

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“…No entanto, o uso de produtos químicos sintéticos e os impactos de suas cadeias produtivas causam sérios danos ao meio ambiente; por exemplo, contaminações de solos e corpos aquáticos, e a emissão de gases de efeito estufa, que têm forte repercussão no meio ambiente e em mudanças climáticas (ENRÍQUEZ-DE-SALAMANCA et al, 2017;RAO SATHIAVELU;MYTHILI, 2016;VILLARREAL-CHIU;ARÉCHIGA-CARVAJAL, 2016). Assim, com o aumento das preocupações sobre a sustentabilidade dos recursos naturais do planeta e a fim de responder às novas demandas das indústrias químicas e indústrias associadas, o uso de produtos biossintéticos torna-se uma estratégia de grande potencial (GARCÍA-SERNA; BARRERA; MONTIEL, 2007;CHARPENTIER, 2010).…”

Section: Introductionunclassified

Bioprocessos de Co-Cultivo Microbiano: Avaliação Tecnológica de Patentes

Rodrigues

Gonçalves

Druzian

2019

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Este estudo apresenta uma investigação de patentes para detecção de tendências tecnológicas e de mercado em bioprocessos e síntese de bioprodutos utilizando mais de uma cultura microbiana no meio de cultivo. Patentes de 1909 a 2017 foram coletadas e uma função sigmoide de dois estágios foi ajustada com sucesso (R2 = 0,997) para modelar os documentos prospectados, contribuindo para melhor compreensão do estágio de desenvolvimento da técnica avaliada. Foram encontradas 632 patentes diferentes, publicadas principalmente nos Estados Unidos e China. O setor empresarial foi responsável pelo desenvolvimento de 50% das invenções. O desenvolvimento da técnica está aumentando rapidamente após um período de crescimento lento (1909 a 1997), impulsionado, principalmente, por indústrias de produção de químicos de base biológica e biocombustíveis. O uso de microrganismos no cocultivo em bioprocessos e síntese de bioprodutos revelou alto potencial.

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Genetic Engineering In BioButanol Production And Tolerance

Abstract: The growing need to address current energy and environmental problems has sparked an interest in developing

Cited by 12 publications

References 88 publications

Theoretical and Practical Studies on the Metabolic Engineering of Streptomyces for Production of Butanols

Theoretical and Practical Studies on the Metabolic Engineering of Streptomyces for Production of Butanols

Biobutanol: New era of biofuels

Bioprocessos de Co-Cultivo Microbiano: Avaliação Tecnológica de Patentes

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