Genetic engineering of microorganisms for biodiesel production

Lin, Hui; Wang, Qun; Shen, Qi; Zhan, Junpeng; Zhao, Yanfang

doi:10.4161/bioe.23114

Cited by 50 publications

(24 citation statements)

References 160 publications

(176 reference statements)

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“…A comprehensive review of biodiesel production and application of genetic engineering is that of Lin et al 169 This ideal substitute for petroleum-based diesel is made from triglycerides by transesterification with alcohols. Today, crude oil is consumed at 11.6 million tons per day that cannot last for a long time.…”

Section: Biofuelsmentioning

confidence: 99%

Production of valuable compounds by molds and yeasts

Demain

Martens

2016

J Antibiot

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where he has contributed in a major way to the reputation of this department for many years. He also served as an Adjunct Professor at the University of Geneva. Among Julian's areas of study and accomplishment are fungal toxins including α-sarcin, chemical synthesis of triterpenes, mode of action of streptomycin and other aminoglycoside antibiotics, biochemical mechanisms of antibiotic resistance in clinical isolates of bacteria harboring resistance plasmids, their origins and evolution, secondary metabolism of microorganisms, structure and function of bacterial ribosomes, antibiotic resistance mutations in yeast ribosomes, cloning of resistance genes from an antibiotic-producing microbe, gene cloning for industrial purposes, engineering of herbicide resistance in useful crops, bleomycin-resistance gene in clinical isolates of Staphylococcus aureus and many other topics. He has been an excellent teacher, lecturing in both English and French around the world, and has organized international courses. Julian has also served on the NIH study sections, as Editor for several international journals, and was one of the founders of the journal Plasmid. We expect the impact of Julian's accomplishments to continue into the future.

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Section: Biofuelsmentioning

confidence: 99%

Production of valuable compounds by molds and yeasts

Demain

Martens

2016

J Antibiot

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“…In order to increase growth rates or lipid production, several strategies for a targeted genetic modification of microalgae exist . A frequent approach is the modification or truncation of the light harvesting complexes in the thylakoid membrane of the chloroplasts to reduce absorption of incident sunlight by the outer cells of the algal suspension.…”

Section: Biological Optimizationmentioning

confidence: 99%

Bioenergy from Microalgae – Vision or Reality?

et al. 2018

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Microalgae are often heralded as a miracle cure to solve future questions concerning energy and food supply of the world's population. This is due to their vastly superior area productivity compared to terrestrial plants and the feasibility of cultivating them independently of arable land and fresh water. Algal biomass can be used as food and feed as well as a source for a plethora of biofuels and high value products such as nutraceuticals and pharmaceuticals. This review article seeks to shed light on recent advances in microalgal technology and their potential for the production of biofuels.

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“…Furthermore, due to its modularity, SLMC would allow us to attach additional bioprocesses downstream of the ethanol producing consortium in order to convert ethanol, for example, into biodiesel (Lin et al, 2013 ). Besides an urgent need to transition the world's fuel production from fossil to renewable fuels, biodiesel offers several advantages over petroleum-based diesel, such as being completely biodegradable, non-toxic and reducing emissions of carbon monoxide, sulphur, aromatic hydrocarbons and soot particles (Kalscheuer, 2006 ; Lin et al, 2013 ). While the lignocellulose conversion into sugars followed by their fermentation to ethanol are strictly anaerobic processes, its further transformation into biodiesel requires an oxic environment.…”

Section: Engineering Spatially Linked Microbial Consortia (Slmc)mentioning

confidence: 99%

Synthetic Microbial Ecology: Engineering Habitats for Modular Consortia

Said

2017

Front. Microbiol.

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The metabolic diversity present in microbial communities enables cooperation toward accomplishing more complex tasks than possible by a single organism. Members of a consortium communicate by exchanging metabolites or signals that allow them to coordinate their activity through division of labor. In contrast with monocultures, evidence suggests that microbial consortia self-organize to form spatial patterns, such as observed in biofilms or in soil aggregates, that enable them to respond to gradient, to improve resource interception and to exchange metabolites more effectively. Current biotechnological applications of microorganisms remain rudimentary, often relying on genetically engineered monocultures (e.g., pharmaceuticals) or mixed-cultures of partially known composition (e.g., wastewater treatment), yet the vast potential of “microbial ecological power” observed in most natural environments, remains largely underused. In line with the Unified Microbiome Initiative (UMI) which aims to “discover and advance tools to understand and harness the capabilities of Earth's microbial ecosystems,” we propose in this concept paper to capitalize on ecological insights into the spatial and modular design of interlinked microbial consortia that would overcome limitations of natural systems and attempt to optimize the functionality of the members and the performance of the engineered consortium. The topology of the spatial connections linking the various members and the regulated fluxes of media between those modules, while representing a major engineering challenge, would allow the microbial species to interact. The modularity of such spatially linked microbial consortia (SLMC) could facilitate the design of scalable bioprocesses that can be incorporated as parts of a larger biochemical network. By reducing the need for a compatible growth environment for all species simultaneously, SLMC will dramatically expand the range of possible combinations of microorganisms and their potential applications. We briefly review existing tools to engineer such assemblies and optimize potential benefits resulting from the collective activity of their members. Prospective microbial consortia and proposed spatial configurations will be illustrated and preliminary calculations highlighting the advantages of SLMC over co-cultures will be presented, followed by a discussion of challenges and opportunities for moving forward with some designs.

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Genetic engineering of microorganisms for biodiesel production

Cited by 50 publications

References 160 publications

Production of valuable compounds by molds and yeasts

Production of valuable compounds by molds and yeasts

Bioenergy from Microalgae – Vision or Reality?

Synthetic Microbial Ecology: Engineering Habitats for Modular Consortia

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