Genetic Engineering to Improve Resistance to Viral Diseases of Poultry: A Model for Application to Livestock Improvement

Crittenden, L. B.; Salter, Donald W.

doi:10.4141/cjas85-066

Cited by 12 publications

(6 citation statements)

References 8 publications

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“…However, cells that express viral envelope ( env ) proteins are resistant to infection. This observation led investigators to engineer lines of chickens that would be immune to infection by avian viruses by using modified avian viruses as vectors to deliver env genes to chicken genomes (Crittenden & Salter, 1985, 1986). Transgenic lines of chickens were achieved (Bosselman et al, 1989; Mizuarai et al, 2001; Salter, Smith, Hughes, Wright, & Crittenden, 1987; Thoraval et al, 1995); however, the efficiencies using retroviral vectors were low, the cargo capacity of retroviruses was limited, and some of the transgenic birds shed replicating virus.…”

Section: Introductionmentioning

confidence: 99%

Precision Editing of Large Animal Genomes

Tan

Carlson

Walton

et al. 2012

Advances in Genetics

105

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Transgenic animals are an important source of protein and nutrition for most humans and will play key roles in satisfying the increasing demand for food in an ever-increasing world population. The past decade has experienced a revolution in the development of methods that permit the introduction of specific alterations to complex genomes. This precision will enhance genome-based improvement of farm animals for food production. Precision genetics also will enhance the development of therapeutic biomaterials and models of human disease as resources for the development of advanced patient therapies.

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Section: Introductionmentioning

confidence: 99%

Precision Editing of Large Animal Genomes

Tan

Carlson

Walton

et al. 2012

Advances in Genetics

105

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“…Bulfield (1985) pointed out that there is a lack of known genes of useful effect and discussed ways of identifying them. Single genes which confer resistance to disease, such as the avian leukosis virus envelope antigen gene (Crittenden and Salter, 1985), would also be candidates for addition to the genome. An exception would be changes which block pathways.…”

Section: Area Operation Commentmentioning

confidence: 99%

The Incorporation of Biotechnologies into Animal Breeding Strategies

Gibson

Smith

1989

Animal Biotechnology

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“…Castration abolished the resistance seen in males but this was restored in capons by treatment with testosterone (108,109). Studies on the pathogenesis of LL by Cooper et al (110) revealed that whereas early neoplastic transformation of bursal follicles occurred equaUy in males and females, most birds dying from the disease were females. This sex difference is believed to be a consequence of the earlier natural regression of the bursa in males, under the influence of testosterone, accompanied apparently by regression of transformed follicles.…”

Section: Dosementioning

confidence: 99%

“…Indeed, integration of avian retro\'iral genes at the somatic cell level has recently been achieved by AL V infection during early embryonic development. Stable inheritance, however, has yet to be demonstrated in breeding experiments (110,111). AL V infection might establish integration of fractions of the DNA sequence of the AL V genome, including the env gene (see Chapter 4), and therefore resistance to the homologous viral subgroup might be anticipated, if transformation is established and if the em' gene is properly expressed (112).…”

Section: Insertion Of Retroviral Genesmentioning

confidence: 99%

Avian Leukosis

1987

Developments in Veterinary Virology

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PREFACEThe intention of the series Developments in Veterinary Virology is to provide monographs dealing with the major animal viral diseases. Each volume will include the latest achievements in fundamental research and practical applications and should be readable for people from various disciplines and different backgrounds. The multi-author approach provides the best opportunity to keep each chapter at the highest level and makes the composition of the volumes manageable to the editors. This monograph on Avian Leukosis presents comprehensive reviews on the recent history of avian retrovirus research, on epizootiological, virological, pathological aspects, on tumor induction, the immune response to avian retroviruses, virus-cell interactions and on techniques for diagnosis. The volume deals mainly with exogenous avian leukosis virus (ALV) infections, but one chapter is entirely devoted to endogenous avian leukemia virus. Molecular biology aspects are confined to various oncogenes and to lymphoma induction since retroviruses, including those specific for avian species, have recently been described in detail in the Cold Spring Harbor Laboratory series "Molecular Biology of Tumor Viruses". Two chapters are devoted to the practical application of insights obtained from avian leukosis research: influences of AL V infection on production performance and eradication procedures. The study of avian retrovirus-induced neoplasia led to important developments in the understanding of the nature and development of various tumors in avian species and has also provided, as a result of comparative research, insight into the structure and biology of retroviruses, virus-cell interactions, oncogenes and neoplasia in general. Current knowledge of the viral etiology of tumors, oncogenes, in vitro transformation, defective genomes, helper viruses and endogenous viruses (to name only a few) is for a considerable part based on work performed in the avian system. The genetically defined resistance (or susceptibility) at the cellular level to the various viral subgroups has complicated avian leukemia research, but has at the same time made the research projects of greater scientific interest.Seventeen authors, whose names are listed on a previous page, have contributed to this monograph. I gratefully acknowledge the willingness of all sixteen experts in the various subdisciplines to add a chapter to this volume. Their

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Genetic Engineering to Improve Resistance to Viral Diseases of Poultry: A Model for Application to Livestock Improvement

Cited by 12 publications

References 8 publications

Precision Editing of Large Animal Genomes

Precision Editing of Large Animal Genomes

The Incorporation of Biotechnologies into Animal Breeding Strategies

Avian Leukosis

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