Genetic Epidemiology of Hereditary Prostate Cancer in Finland

Matikainen, Mika; Schleutker, Johanna; Koivisto, Pasi A.; Tammela, Teuvo L.J.; Xu, Jianfeng; Isaacs, William B.; Smith, Jeffrey R.; Carpten, John D.; Stephan, Dietrich A.; Bailey‐Wilson, Joan E.; Trent, Jeffrey M.; Kallioniemi, Olli-P.

doi:10.1097/00005392-199904010-00220

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A Nationwide Register Cohort Study1

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1999

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“…The increased risk was found for all ages, however, it was more pronounced in younger men. Recently, a Finnish case-control study was performed with a similar approach reaching similar conclusions (28).…”

Section: A Nationwide Register Cohort Studymentioning

confidence: 74%

Hereditary Prostate Cancer

Damber

1999

Scandinavian Journal of Urology and Nephrology

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Recent research makes it probable that there is a hereditary form of prostate cancer. By identifying prostate cancer cases in the Swedish twin registry it was possible to show a pronounced difference in proband concordance rates and correlation of liability between monozygotic and dizygotic twin pairs, which indicates strongly that genetic factors are important for prostate cancer. In a nation-wide register cohort study it was found that the risk for prostate cancer was approximately two times higher among sons to prostate cancer patients when compared to Swedish men in general. By linkage analyses at least two loci for putative prostate cancer genes have been identified, one on chromosome 1 (1q24-25) and one on the X-chromosome (Xq27-28). Before genetic testing becomes available it was suggested that men with the familiar aggregation of prostate cancer should be evaluated with a PSA test on a regular basis.

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Section: A Nationwide Register Cohort Studymentioning

confidence: 74%

Hereditary Prostate Cancer

Damber

1999

Scandinavian Journal of Urology and Nephrology

View full text Add to dashboard Cite

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Genetic Epidemiology of Hereditary Prostate Cancer in Finland

Cited by 1 publication

References 251 publications

Hereditary Prostate Cancer

Hereditary Prostate Cancer

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