Genetic, Epigenetic, and Environmental Influences on Dentofacial Structures and Oral Health: Ongoing Studies of Australian Twins and Their Families

Hughes, Toby; Bockmann, Michelle; Mihailidis, Suzanna; Bennett, Corinna N.; Harris, Abbe; Seow, W.K.; Lekkas, Dimitra; Ranjitkar, Sarbin; Rupinskas, Loreta; Pinkerton, Sandra K.; Brook, Alan; Smith, Richard N.; Townsend, Grant

doi:10.1017/thg.2012.78

Cited by 27 publications

(20 citation statements)

References 37 publications

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“…amelogenesis imperfecta). However, there is now emerging evidence supporting a genetic predisposition to caries in some populations [34–36]. The belief that hereditary factors contribute to caries is not exclusive to our study, as these views were also held by Latino immigrant caregivers in another investigation [24].…”

Section: Discussionmentioning

confidence: 49%

Diversity Considerations for Promoting Early Childhood Oral Health: A Pilot Study

Prowse

Schroth

Wilson

et al. 2014

International Journal of Dentistry

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Objectives. Several groups in Manitoba, Canada, experience early childhood caries (ECC), including Aboriginal, immigrant, and refugee children and those from select rural regions. The purpose of this pilot study was to explore the views of parents and caregivers from four cultural groups on early childhood oral health and ECC. Methods. A qualitative descriptive study design using focus groups recruited parents and caregivers from four cultural groups. Discussions were documented, audio-recorded, transcribed, and then analyzed for content based on themes. Results. Parents and caregivers identified several potential barriers to good oral health practice, including child's temperament, finances, and inability to control sugar intake. Both religion and genetics were found to influence perceptions of oral health. Misconceptions regarding breastfeeding and bottle use were present. One-on-one discussions, parental networks, and using laypeople from similar backgrounds were suggested methods to promote oral health. The immigrant and refugee participants placed emphasis on the use of visuals for those with language barriers while Hutterite participants suggested a health-education approach. Conclusions. These pilot study findings provide initial insight into the oral health-related knowledge and beliefs of these groups. This will help to inform planning of ECC prevention and research strategies, which can be tailored to specific populations.

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Section: Discussionmentioning

confidence: 49%

Diversity Considerations for Promoting Early Childhood Oral Health: A Pilot Study

Prowse

Schroth

Wilson

et al. 2014

International Journal of Dentistry

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“…The zygosities of all of the twins included in the study have been confirmed as part of a larger ongoing investigation of dento-facial growth and oral health in Australian twins. [13][14][15] Dental models of twins were excluded if they were outside the age range of 8-11 years, if the models were damaged in any way, if primary teeth to be measured had a large surface restoration which interfered with the measurement criteria, if there was significant loss of tooth structure due to caries and/or tooth wear, or if there was any craniofacial malformation, e.g. cleft lip or palate.…”

Section: Samplesmentioning

confidence: 99%

Prevalence of infraocclusion of primary molars determined using a new 2D image analysis methodology

Odeh

Mihailidis

Townsend

et al. 2016

Australian Dental Journal

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Publishing in a subscription based journal Accepted (peer-reviewed) VersionThe accepted version of an article is the version that incorporates all amendments made during the peer review process, but prior to the final published version (the Version of Record, which includes; copy and stylistic edits, online and print formatting, citation and other linking, deposit in abstracting and indexing services, and the addition of bibliographic and other material.Self-archiving of the accepted version is subject to an embargo period of 12-24 months. The embargo period is 12 months for scientific, technical, and medical (STM) journals and 24 months for social science and humanities (SSH) journals following publication of the final article.• the author's personal website • the author's company/institutional repository or archive • not for profit subject-based repositories such as PubMed Central Articles may be deposited into repositories on acceptance, but access to the article is subject to the embargo period. The version posted may not be updated or replaced with the final published version (the Version of Record). Authors may transmit, print and share copies of the accepted version with colleagues, provided that there is no systematic distribution, e.g. a posting on a listserve, network or automated delivery.There is no obligation upon authors to remove preprints posted to not for profit preprint servers prior to submission. June 2017 Accepted ArticleThis article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/adj.12349 This article is protected by copyright. All rights reserved. Accepted ArticleThis article is protected by copyright. All rights reserved. AbstractBackground: The reported prevalence of infraocclusion varies widely, reflecting differences in definitions and measurement/scoring approaches. Aims:This study aimed to quantify the prevalence and extent of infraocclusion in singletons and twins during the late mixed dentition stage of dental development using a new diagnostic imaging method and objective criteria. The study also aimed to determine any associations between infraocclusion and sex, arch type, arch side and tooth type.Design: Two samples were analysed; 1,454 panoramic radiographs of singletons and 270 dental models of twins. Both samples ranged in age from 8-11 years. Adobe Photoshop CS5 was used to measure the extent of infraocclusion. Repeatability tests showed systematic and random errors were small. Results:The prevalence in the maxilla was low (<1%), whereas the prevalence in the mandible was 22% in the singleton sample and 32% in the twin sample. The primary mandibular first molar was affected more often than the second molar. There was no significant difference in the expression between sexes or sides. Conclusion:A new technique for measuring infraocclusion has been d...

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“…A recent review on dental caries and genetics stressed the need for robust phenotype definitions and properly powered candidate-gene and genome-wide linkage and association studies [Vieira et al, 2014]. Ongoing twin studies [Hughes et al, 2013] will provide highly valuable information on the role of genetic, epigenetic and environmental factors on oral health.…”

Section: Healthy Oral Ecosystemmentioning

confidence: 99%

Towards Understanding Oral Health

Zaura

Cate

2015

Caries Res

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During the last century, dental research has focused on unraveling the mechanisms behind various oral pathologies, while oral health was typically described as the mere absence of oral diseases. The term ‘oral microbial homeostasis' is used to describe the capacity of the oral ecosystem to maintain microbial community stability in health. However, the oral ecosystem itself is not stable: throughout life an individual undergoes multiple physiological changes while progressing through infancy, childhood, adolescence, adulthood and old age. Recent discussions on the definition of general health have led to the proposal that health is the ability of the individual to adapt to physiological changes, a condition known as allostasis. In this paper the allostasis principle is applied to the oral ecosystem. The multidimensionality of the host factors contributing to allostasis in the oral cavity is illustrated with an example on changes occurring in puberty. The complex phenomenon of oral health and the processes that prevent the ecosystem from collapsing during allostatic changes in the entire body are far from being understood. As yet individual components (e.g. hard tissues, microbiome, saliva, host response) have been investigated, while only by consolidating these and assessing their multidimensional interactions should we be able to obtain a comprehensive understanding of the ecosystem, which in turn could serve to develop rational schemes to maintain health. Adapting such a ‘system approach' comes with major practical challenges for the entire research field and will require vast resources and large-scale multidisciplinary collaborations.

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Genetic, Epigenetic, and Environmental Influences on Dentofacial Structures and Oral Health: Ongoing Studies of Australian Twins and Their Families

Cited by 27 publications

References 37 publications

Diversity Considerations for Promoting Early Childhood Oral Health: A Pilot Study

Diversity Considerations for Promoting Early Childhood Oral Health: A Pilot Study

Prevalence of infraocclusion of primary molars determined using a new 2D image analysis methodology

Towards Understanding Oral Health

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