Genetic evaluation of traits distributed as Poisson-binomial with reference to reproductive characters

Foulley, JL; Gianola, Daniel; Im, Sungbin

doi:10.1007/bf00289392

Cited by 60 publications

(69 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A Poisson mixture model is sometimes used with count data [Foulley et al, 1987], but the Poisson distribution is constrained because the variance is equal to the mean. A mixture model based on the negative-binomial distribution allows more flexibility, and is therefore more appropriate for count variables with overdispersion relative to the Poisson distribution [Tempelman and Gianola, 1996].…”

Section: Methodsmentioning

confidence: 99%

Intrafamilial correlation of clinical manifestations in neurofibromatosis 2 (NF2)

Zhao

Kumar

Baser³

et al. 2002

Genetic Epidemiology

View full text Add to dashboard Cite

Measuring correlation in clinical traits among relatives is important to our understanding of the causes of variable expressivity in Mendelian diseases. Random effects models are widely used to estimate intrafamilial correlations, but such models have limitations. We incorporated survival techniques into a random effects model so that it can be used to estimate intrafamilial correlations in continuous variables with right censoring, such as age at onset. We also describe a negative-binomial gamma mixture model to determine intrafamilial correlations of discrete (e.g., count) data. We demonstrate the utility of these methods by analyzing intrafamilial correlations among patients with neurofibromatosis 2 (NF2), an autosomal-dominant disease caused by mutations of the NF2 tumor-suppressor gene. We estimated intrafamilial correlations in age at first symptom of NF2, age at onset of hearing loss, and number of intracranial meningiomas in 390 NF2 nonprobands from 153 unrelated families. A significant intrafamilial correlation was observed for each of the three features: age at onset (0.35; 95% confidence interval (CI) 0.23-0.47), age at onset of hearing loss (0.51; 95% CI, 0.35-0.64), and number of meninginomas (0.29; 95% CI, 0.15-0.43). Significant correlations were also observed for age at first symptom within NF2 families with truncating mutations (0.41; 95% CI, 0.06-0.68) or splice-site mutations (0.29; 95% CI, 0.03-0.51), for age at onset of hearing loss within families with missense mutations (0.67; 95% CI, 0.18-0.89), and for number of meningiomas within families with splice-site mutations (0.39; 95% CI, 0.13-0.66). Our findings are consistent with effects of both allelic and nonallelic familial factors on the clinical variability of NF2.

show abstract

Section: Methodsmentioning

confidence: 99%

Intrafamilial correlation of clinical manifestations in neurofibromatosis 2 (NF2)

Zhao

Kumar

Baser³

et al. 2002

Genetic Epidemiology

View full text Add to dashboard Cite

show abstract

“…As a working approximation, a Poisson distribution for litter size is assumed (see, e.g. Foulley et al, 1987;Matos et al, 1997), the major consequence being that the variance of litter size is taken as being equal to the mean.…”

Section: Model Of Population Growthmentioning

confidence: 99%

A model for population growth of laboratory animals subjected to marker-assisted introgression: how many animals do we need?

1999

View full text Add to dashboard Cite

This study provides methods for calculating the mean and variance of the number of animals with the desired genotype in each backcross generation for a marker-assisted introgression experiment. The ultimate goal is to produce animals which are homozygous for the desired loci. The methods have been developed specifically for experiments with inbred lines. The model assumes a Poisson distribution for litter size, and is similar to that used in stochastic versions of population dynamics models. Certain biological parameters must be specified as well as parameters under the control of the breeder. These methods can be utilized in designing an experiment to determine the number of founder animals required, given the number of animals required at the completion of the backcross process and vice versa. Consideration is given to minimizing the total amount of genotyping over the entire experiment, by varying the number of times each backcrossed male is used. In addition, an outline is given for an adaptive design that allows for changes in male usage to be made during the experiment.

show abstract

“…Bayesian methodology has been established as a general framework for the analysis of any type of observation arising in animal production (Foulley & Gianola, 1984;Gianola et al, 1986;H6schele et al, 1986, 1987Foulley et al, 1987aFoulley et al, , 1987b). …”

Section: Introductionmentioning

confidence: 99%

Estimation of covariance components between one continuous and one binary trait

Simianer¹,

Schaeffer²

1989

Genet. Sel. Evol.

View full text Add to dashboard Cite

show abstract

Genetic evaluation of traits distributed as Poisson-binomial with reference to reproductive characters

Cited by 60 publications

References 16 publications

Intrafamilial correlation of clinical manifestations in neurofibromatosis 2 (NF2)

Intrafamilial correlation of clinical manifestations in neurofibromatosis 2 (NF2)

A model for population growth of laboratory animals subjected to marker-assisted introgression: how many animals do we need?

Estimation of covariance components between one continuous and one binary trait

Contact Info

Product

Resources

About