Genetic evidence of gene flow from Indians to Malays

Teng, Yun; Tan, Soon Guan

doi:10.1007/bf01890105

Cited by 4 publications

(2 citation statements)

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“…STRUCTURE and PCA results revealed the possible presence of recent admixture in both the Malaysian negrito groups, but was more pronounced in the Jehai, shown by the comet-like gradient in the PCA plots (Figures 1 and 4). The source population for the admixture was most likely the Malay, as shown in Figure 4, and is quite reasonable given that the Malays are the most populous ethnic group with a history of admixture (Vlieland 1934;Teng and Tan 1979;Andaya 2001) and are found in most geographical regions in West Malaysia, including the rural areas where most of the negrito groups are found. There have been attempts by the Malaysian federal government and/or individual bodies to resettle the negritos into permanent villages.…”

Section: Discussionmentioning

confidence: 85%

Admixture Patterns and Genetic Differentiation in Negrito Groups from West Malaysia Estimated from Genome-wide SNP Data

2013

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Southeast Asia houses various culturally and linguistically diverse ethnic groups. In Malaysia, where the Malay, Chinese, and Indian ethnic groups form the majority, there exist minority groups such as the "negritos" who are believed to be descendants of the earliest settlers of Southeast Asia. Here we report patterns of genetic substructure and admixture in two Malaysian negrito populations ( Jehai and Kensiu), using ~50,000 genomewide single-nucleotide polymorphism (SNP) data. We found traces of recent admixture in both the negrito populations, particularly in the Jehai, with the Malay through principal component analysis and STRUCTURE analysis software, which suggested that the admixture was as recent as one generation ago. We also identified significantly differentiated nonsynonymous SNPs and haplotype blocks related to intracellular transport, metabolic processes, and detection of stimulus. These results highlight the different levels of admixture experienced by the two Malaysian negritos. Delineating admixture and differentiated genomic regions should be of importance in designing and interpretation of molecular anthropology and disease association studies. Abstract Southeast Asia houses various culturally and linguistically diverse ethnic groups. In Malaysia, where the Malay, Chinese, and Indian ethnic groups form the majority, there exist minority groups such as the "negritos" who are believed to be descendants of the earliest settlers of Southeast Asia. Here we report patterns of genetic substructure and admixture in two Malaysian negrito populations (Jehai and Kensiu), using ~50,000 genome-wide single-nucleotide polymorphism (SNP) data. We found traces of recent admixture in both the negrito populations, particularly in the Jehai, with the Malay through principal component analysis and STRUCTURE analysis software, which suggested that the admixture was as recent as one generation ago. We also identified significantly differentiated nonsynonymous SNPs and haplotype blocks related to intracellular transport, metabolic processes, and detection of stimulus. These results highlight the different levels of admixture experienced by the two Malaysian negritos. Delineating admixture and differentiated genomic regions should be of importance in designing and interpretation of molecular anthropology and disease association studies.The Southeast Asian region represents an intriguing avenue into the study of human population genetics, given the rich ethnic diversity of the region. The general consensus from various population genetic studies are the African origin of modern human populations based on mitochondrial, Y-chromosomal, and autosomal DNA markers (e.g., Underhill 2003;Li et al. 2008;Stoneking and Delfin 2010). With

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Section: Discussionmentioning

confidence: 85%

Admixture Patterns and Genetic Differentiation in Negrito Groups from West Malaysia Estimated from Genome-wide SNP Data

2013

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“…Possible admixture between Malays and Indians was first shown genetically using biochemical markers [30] . Even though the admixture could have occurred during the British colonial period from the 19 th to the middle of the 20 th century when massive migration of Indian laborers to the west coast of Peninsular Malaysia to work on the railroad and in the rubber and oil palm plantation industries took place [5] , we believed that the admixture between MY-KN and Indians was very ancient and had happened during the early existence of the Malays.…”

Section: Resultsmentioning

confidence: 99%

Population Genetic Structure of Peninsular Malaysia Malay Sub-Ethnic Groups

et al. 2011

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Patterns of modern human population structure are helpful in understanding the history of human migration and admixture. We conducted a study on genetic structure of the Malay population in Malaysia, using 54,794 genome-wide single nucleotide polymorphism genotype data generated in four Malay sub-ethnic groups in peninsular Malaysia (Melayu Kelantan, Melayu Minang, Melayu Jawa and Melayu Bugis). To the best of our knowledge this is the first study conducted on these four Malay sub-ethnic groups and the analysis of genotype data of these four groups were compiled together with 11 other populations' genotype data from Indonesia, China, India, Africa and indigenous populations in Peninsular Malaysia obtained from the Pan-Asian SNP database. The phylogeny of populations showed that all of the four Malay sub-ethnic groups are separated into at least three different clusters. The Melayu Jawa, Melayu Bugis and Melayu Minang have a very close genetic relationship with Indonesian populations indicating a common ancestral history, while the Melayu Kelantan formed a distinct group on the tree indicating that they are genetically different from the other Malay sub-ethnic groups. We have detected genetic structuring among the Malay populations and this could possibly be accounted for by their different historical origins. Our results provide information of the genetic differentiation between these populations and a valuable insight into the origins of the Malay sub-ethnic groups in Peninsular Malaysia.

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Genetic Relationships between Indian Populations and Their Neighbors

Roychoudhury

1984

The People of South Asia

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Genetic evidence of gene flow from Indians to Malays

Cited by 4 publications

References 30 publications

Admixture Patterns and Genetic Differentiation in Negrito Groups from West Malaysia Estimated from Genome-wide SNP Data

Admixture Patterns and Genetic Differentiation in Negrito Groups from West Malaysia Estimated from Genome-wide SNP Data

Population Genetic Structure of Peninsular Malaysia Malay Sub-Ethnic Groups

Genetic Relationships between Indian Populations and Their Neighbors

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