Genetic Factors and Characteristics on Spectral-Domain Optical Coherence Tomography Are Associated to Choroidal Thickness in ABCA4-Related Retinopathy Factors of Choroidal Thickness in ABCA4 Retinopathy

Wang, Yimin; Chen, Jieqiong; Zhang, Min; Yu, Suqin; Gong, Yuanyuan; Lin, Feng; Wu, Yidong; Liu, Wenjia; Sun, Junran; Li, Tong; Sun, Xiaodong; ,

doi:10.1097/iae.0000000000003931

Cited by 2 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the past decade, optical coherence tomography (OCT)/OCT angiography (OCTA) has enabled noninvasive imaging of the microvasculature alongside macular morphology simultaneously. Although previous studies have attempted to correlate macular curvature with biometrics such as axial length, the results have been inconsistent [ 17 , 21 , 26 ], possibly because of the significant inter-individual variability and confounding effect in age, gender, genotype, and environment. Moreover, the association of macular curvature with macular microvascularity represents a significant gap in our current understanding.…”

Section: Introductionmentioning

confidence: 99%

Assessment of OCT-Based Macular Curvature and Its Relationship with Macular Microvasculature in Children with Anisomyopia

Wu,

Liu,

Liu

et al. 2024

Ophthalmol Ther

View full text Add to dashboard Cite

Introduction To evaluate the intraocular differences in optical coherence tomography (OCT)-based macular curvature index (MCI) among children with anisomyopia and to investigate the relationship between MCI and the macular microvasculature. Methods Fifty-two schoolchildren with anisometropia > 2.00 D were enrolled and underwent comprehensive examinations including cycloplegic refraction, axial length (AL), and swept source OCT/OCT angiography. OCT-based MCIs were determined from horizontal and vertical B-scans by a customized curve fitting model in MATLAB R2022 at 1-mm-, 3-mm-, and 6-mm-diameter circles at fovea. Characteristics and topographic variation of MCI was analyzed, and the relationships with microvascularity and its associated factors were investigated. Results MCI achieved high reliability and repeatability. There were overall larger MCIs in the more myopic eyes than the less myopic eyes in 1-mm-, 3-mm-, and 6-mm-diameter circles at fovea (all p < 0.001). For the topographic variation, horizontal MCI was significantly greater than vertical MCI (all p < 0.001), and was the largest in 6-mm circle, followed by 3-mm and 1-mm circles. Stronger correlation of horizontal MCI with myopic severity than vertical MCI was found. Partial Pearson’s correlation found MCI was negatively associated with deep capillary plexus (DCP) vessel density ( p = 0.016). Eyes with a higher MCI in a 6-mm circle were more likely to have longer AL ( p < 0.001), lower DCP vessel density ( p = 0.037), and thinner choroidal thickness (ChT) ( p = 0.045). Conclusion Larger MCI was found in the more myopic eyes of children with anisomyopia and was significantly associated with smaller DCP density, suggesting that MCI was an important indicator of myopia-related retinal microvascularity change, and it could be a valuable metric for myopia assessment in children. Supplementary Information The online version contains supplementary material available at 10.1007/s40123-024-00956-5.

show abstract

Section: Introductionmentioning

confidence: 99%