Genetic factors in chemically‐induced transitional cell bladder cancer

Filiadis, Ioannis; Hrouda, David

doi:10.1046/j.1464-410x.2000.00940.x

Cited by 11 publications

(9 citation statements)

References 57 publications

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“…These results suggest that there is a correlation between GSTM1 genotype and the level of gene expression. These findings are in accordance with previous reports that the GSTM1-null genotype was a risk factor for BC [6,7]. Although GSTT1 acts as a scavenger of electrophiles, for some compounds it acts as a metabolic activator.…”

Section: Discussionsupporting

confidence: 93%

“…It is capable of metabolizing a wide range of chemicals, and prevents organic hydroperoxides from enhancing free radical propagation through the activity of GST peroxidase [4,5]. The GSTM1-null genotype has therefore been considered a risk factor for bladder cancer (BC) [6,7]. However, the GSTT1-mediated conjugation of xenobiotics may generate compounds that are more toxic than the parent compounds [4,8].…”

Section: Introductionmentioning

confidence: 99%

“…This mechanism may explain the greater susceptibility of GSTT1-positive individuals to BC [9]. It therefore remains unclear whether the GSTT1-null genotype is a risk factor or a protective factor for BC [6,[9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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GSTT1: A Marker of the Aggressiveness of Bladder Cancer

Yan

Park

et al. 2010

Urol Int

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Introduction: Glutathione S-transferases have been implicated in the development of bladder cancer (BC). We investigated the genotype and expression of glutathione S-transferase-mu (GSTM1) and glutathione S-transferase-theta (GSTT1) in BC tissue specimens. Materials and Methods: Tumor samples and matched normal mucosae were obtained from 34 patients. Genomic DNA was used to analyze GSTM1 and GSTT1 genotypes using multiplex polymerase chain reaction. GSTM1 and GSTT1 mRNA levels were measured using real-time reverse transcriptase polymerase chain reaction. Results:GSTM1 mRNA expression was lower in tumor tissues than in matched normal bladder mucosae, whereas GSTT1 mRNA expression was significantly higher. GSTT1 mRNA expression was higher in muscle-invasive BC and high-grade cancers than in non-muscle-invasive BC and lower-grade tumors. Conclusions:GSTT1 is correlated with characteristics of aggressive BC. GSTT1 may play an important role in tumorigenesis and disease progression in patients with BC.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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GSTT1: A Marker of the Aggressiveness of Bladder Cancer

Yan

Park

et al. 2010

Urol Int

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“…20 Almost all compounds known to be risk factors for bladder tumors are also important sources of free radicals, which exert their effects either directly, like those present in cigarette smoke, or during the metabolism of carcinogenic agents, such as polycyclic aromatic hydrocarbons (PAHs). 20,21 In particular, the formation of DNA adducts due to increased ROS generation during the conversion of PAHs to quinones is well documented. 22 It can be assumed that during malignant transformation a significant perturbation of cellular redox status occurs, which can result in ROS-mediated DNA damage, gene mutations and structural alterations to the DNA.…”

Section: Commentmentioning

confidence: 99%

GSTM1-null and GSTA1-low activity genotypes are associated with enhanced oxidative damage in bladder cancer

et al. 2013

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“…Wesentlich für die Empfindlichkeit gegenüber chemischen Kanzerogenen ist die individuell unterschiedliche Ausstattung mit Enzymen,die diese metabolisieren und dabei giften oder entgiften. Diese Ausstattung ist wesentlich konstitutiv genetisch bestimmt [2]. Beim Harnblasenkarzinom sind 2 Enzymfamilien als besonders relevant erkannt worden:…”

Section: Prädisposition Exposition Und Risiko Der Entwicklung Eines unclassified

Perspektiven der molekularen Diagnostik dargestellt am Beispiel des Harnblasenkarzinoms

2003

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The rapidly growing knowledge of molecular mechanisms will change the daily routine of clinicians in the near future. Regarding urothelial bladder carcinoma, one may expect that molecular diagnostics will identify patients susceptible to disease development by screening their genotype. Furthermore, in addition to histopathologic findings, prognostic markers will be used for disease management. In an ongoing multicenter trial, the decision on whether or not to treat patients with adjuvant chemotherapy after cystectomy is based on their p53 status. In the near future, cytostatic medications are expected to be chosen according to genetic profiles of the tumor or patient. New medications, which target tumor-specific alterations of cell-signaling cascades in bladder or other cancers, prominently inhibitors of the ERBB membrane receptor family, are currently under clinical investigation and will undoubtedly form an important part of therapeutic oncologic regimens. In conclusion, evaluation of gene profiles of tumors and patients will gain importance for clinicians.

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Genetic factors in chemically‐induced transitional cell bladder cancer

Cited by 11 publications

References 57 publications

GSTT1: A Marker of the Aggressiveness of Bladder Cancer

GSTT1: A Marker of the Aggressiveness of Bladder Cancer

GSTM1-null and GSTA1-low activity genotypes are associated with enhanced oxidative damage in bladder cancer

Perspektiven der molekularen Diagnostik dargestellt am Beispiel des Harnblasenkarzinoms

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