Genetic factors: influence on the development of thyroid diseases and rheumatic diseases

Abstract

The article discusses the presence of common genes in RA and thyroid disease.Methods: Published studies that enrolled adult patients with rheumatoid arthritis (RA) and autoimmune thyroid pathology were identified by searches of Medline and Embase, and by manual searches of medical journals. Meta-analyses were performed to assess the association of SE presence, dose, and genotype with rheumatoid arthritis and autoimmune thyroid pathology.Results: A total of studies 133 patients were included in the analysis. RA patients have increase in the frequency of the Gene DR B1 (p<0.05, OR=3, 2, 95% CI=1, 4-6, 8), the gene B8 (p<0.05, RR=2, 6; 95% CI=1, 8-4, 3). In patients with autoimmune thyroid disease, most frequently found genes HLA-B8 (94% patients) HLA-DR3 (67%) and HLA-DR5 (72%). Conclusion:According to the obtained results it is concluded that the presence of the HLA -B8 gene can cause of RA in patients with autoimmune thyroid pathology.