Genetic improvement of tomato using gene editing technologies

Nagamine, Ai; Takayama, M.; Ezura, Hiroshi

doi:10.1080/14620316.2022.2091489

Cited by 8 publications

(4 citation statements)

References 46 publications

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“…Genome editing is the technique by which DNA mutations in insertion and deletion (InDels) or base substitutions are introduced to create an organism with a new or modified product [133,155,156]. There are different types of genome editing methods, as described below.…”

Section: Genome Editingmentioning

confidence: 99%

Multiple Foliar Fungal Disease Management in Tomatoes: A Comprehensive Approach

Panthee,

Pandey,

Paudel

2024

IJPB

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Foliar diseases are the significant production constraints in tomatoes. Among them, foliar fungal diseases in tomatoes, such as early blight (Alternaria linaria), Septoria leaf spot (Septoria lycopersici), and late blight (Phytophthora infestans), which is oomycetes, have higher economic significance. This paper will discuss the etiology, host range, distribution, symptoms, and disease cycle to help us understand the biology, followed by management approaches emphasizing the resistance breeding approach for these diseases. We provide an analytical review of crop improvement efforts, including conventional and molecular methods for improving these diseases’ resistance. We discuss the importance of modern breeding tools, including genomics, genetic transformation, and genome editing, to improve the resistance to these diseases in the future.

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Section: Genome Editingmentioning

confidence: 99%

Multiple Foliar Fungal Disease Management in Tomatoes: A Comprehensive Approach

Panthee,

Pandey,

Paudel

2024

IJPB

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“…Gene-edited tomatoes have come onto the market with a 20-fold increase in GABA content and have hypotensive effects upon consumption (Ezura, 2022;Minako et al, 2023;Nagamine et al, 2022). of GABA-enriched products.…”

Section: G Aba a S A Neuro -N Utr Aceuti C Almentioning

confidence: 99%

“…Gene‐edited tomatoes have come onto the market with a 20‐fold increase in GABA content and have hypotensive effects upon consumption (Ezura, 2022; Minako et al., 2023; Nagamine et al., 2022). While the market may indicate that GABA is indeed a neuro‐nutraceutical, other constituents, such as flavonoids and other polyphenols, may contribute to the increased beneficial effects of GABA‐enriched products.…”

Section: Gaba As a Neuro‐nutraceuticalmentioning

confidence: 99%

Milestone review: GABA, from chemistry, conformations, ionotropic receptors, modulators, epilepsy, flavonoids, and stress to neuro‐nutraceuticals

Johnston,

Beart

2024

Journal of Neurochemistry

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Arising out of a PhD project more than 50 years ago to synthesise analogues of the neurotransmitter GABA, a series of new chemical entities were found to have selective actions on ionotropic GABA receptors. Several of these neurochemicals are now commercially available. A new subtype of these receptors was discovered that could be a target for the treatment of myopia, the facilitation of learning and memory, and the improvement of post‐stroke motor recovery. The development of these new chemical entities over many years demonstrates the importance of neurochemicals with which to investigate selective aspects of GABA receptors and illustrates the significance of collaboration between chemists and biologists in neurochemistry. Vital were the improvements in synthetic organic chemistry and the use of functional human receptors expressed in oocytes. Current interest in ionotropic GABA receptors includes the clinical development of subtype‐specific agents and the role of gain‐of‐function receptor variants in epilepsy. Dietary flavonoids were found to cross the blood–brain barrier to influence brain function. Natural and synthetic flavonoids had a range of effects on GABA receptors, ranging from positive, silent, and negative allosteric modulators, to even second‐order modulation of first‐order modulators. Flavonoids have been called “a new family of benzodiazepines.” Like benzodiazepines, flavonoids reduce stress. Stress produces changes in GABA receptors in the brain that may be because of changes in endogenous modulators, such as neurosteroids and corticosteroids. GABA also occurs naturally in the diet leading to studies of the effects of oral GABA on brain function. This finding has resulted in studies of GABA and related neurochemicals as neuro‐nutraceuticals. GABA systems in the gut microbiome are essential to such studies. The actions of oral GABA and of GABA‐enriched beverages and foodstuffs are now an area of considerable scientific and commercial interest. GABA is a deceptively simple chemical that can take up many shapes, which may underlie its complex functions. The need for new chemical entities with selective actions for further studies highlights the need for continuing collaboration between chemists and biologists.

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“…Genome editing is the technique by which DNA mutation in insertion and deletion (InDels) or base substitutions are introduced to create an organism with a new or modified product [124,145,146]. There are different types of genome-editing methods, as described below.…”

Section: Genome Editingmentioning

confidence: 99%

Resistance to Multiple Foliar Fungal Diseases in Tomato

Panthee¹,

Pandey²,

Paudel³

2023

Preprint

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Foliar fungal diseases in tomatoes include early blight (Alternaria linariae), Septoria leaf spot (Septoria lycopersici), and late blight (Phytophthora infestans) which is oomycetes. These are one of the significant production constraints in tomatoes. We describe the etiology, host range, distribution, symptoms, and disease cycle to understand the biology followed by management practices emphasizing the resistance breeding approach for these diseases. In crop improvement efforts, we provide an analytical review, including conventional and molecular methods for improving this disease resistance. Modern breeding tools, including genomics, genetic transformation, and genome editing, can be used to improve these traits. There is a good possibility of using these tools in the future to improve these traits.

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Genetic improvement of tomato using gene editing technologies

Cited by 8 publications

References 46 publications

Multiple Foliar Fungal Disease Management in Tomatoes: A Comprehensive Approach

Multiple Foliar Fungal Disease Management in Tomatoes: A Comprehensive Approach

Milestone review: GABA, from chemistry, conformations, ionotropic receptors, modulators, epilepsy, flavonoids, and stress to neuro‐nutraceuticals

Resistance to Multiple Foliar Fungal Diseases in Tomato

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