Genetic influence demonstrated for MEG-recorded somatosensory evoked responses

Ent, Dennis van ‘t; Soelen, I.L.C. van; Stam, Kelly; Geus, Eco J. C. de; Boomsma, Dorret I.

doi:10.1111/j.1469-8986.2010.01012.x

Cited by 5 publications

(7 citation statements)

References 25 publications

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“…One hundred subjects (50 same-sex monozygotic twin pairs) will be studied using both resting and task evoked MEG. The use of twin pairs allows evaluation of heritable traits, and recent studies have shown that MEG responses to somatosensory stimuli are partly heritable (Van’t Ent et al, 2010). These 100 subjects will also participate in the full HCP study design including structural and functional magnetic resonance image studies (MRI, fMRI), diffusion tensor imaging (dMRI) and behavioral and genetic testing (see (Van Essen et al, 2012)).…”

Section: The Electrophysiological Approach To Connectomicsmentioning

confidence: 99%

Adding dynamics to the Human Connectome Project with MEG

et al. 2013

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The Human Connectome Project (HCP) seeks to map the structural and functional connections between network elements in the human brain. Magnetoencephalography (MEG) provides a temporally rich source of information on brain network dynamics and represents one source of functional connectivity data to be provided by the HCP. High quality MEG data will be collected from 50 twin pairs both in the resting state and during performance of motor, working memory and language tasks. These data will be available to the general community. Additionally, using the cortical parcellation scheme common to all imaging modalities, the HCP will provide processing pipelines for calculating connection matrices as a function of time and frequency. Together with structural and functional data generated using magnetic resonance imaging methods, these data represent a unique opportunity to investigate brain network connectivity in a large cohort of normal adult human subjects. The analysis pipeline software and the dynamic connectivity matrices that it generates will all be made freely available to the research community.

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Section: The Electrophysiological Approach To Connectomicsmentioning

confidence: 99%

Adding dynamics to the Human Connectome Project with MEG

et al. 2013

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“…In previous studies, it has been reported that amplitude and dipole moment of MEF1 does not change even if finger movement intensity and frequency are changed (Mayville et al, 2005; Onishi et al, 2006). In addition, Van’t Ent et al (2010) reported that amplitude of somatosensory-evoked magnetic field (SEF) is influenced by genetics. SEF induced by electrical nerve stimulation reflects peripheral afferents as well as MEF1.…”

Section: Discussionmentioning

confidence: 99%

“…For example, using EEG, the genetic effects on amplitudes and waveforms of several evoked potentials were reported by comparing MZ twins with DZ twins or unrelated pairs (Lewis et al, 1972). Recently, Van’t Ent et al (2010) revealed genetic influences on waveform amplitude and morphology of entire time series of somatosensory-evoked brain activity in a sample of MZ and DZ twins. However, published twin studies concerning brain activity were limited to primary sensory functions such as visual, auditory, and somatosensory-evoked potentials, and there are no reports to this date on motor-related brain function.…”

Section: Introductionmentioning

confidence: 99%

Genetic and Environmental Influences on Motor Function: A Magnetoencephalographic Study of Twins

Araki

Hirata

Sugata

et al. 2014

Front. Hum. Neurosci.

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To investigate the effect of genetic and environmental influences on cerebral motor function, we determined similarities and differences of movement-related cortical fields (MRCFs) in middle-aged and elderly monozygotic (MZ) twins. MRCFs were measured using a 160-channel magnetoencephalogram system when MZ twins were instructed to repeat lifting of the right index finger. We compared latency, amplitude, dipole location, and dipole intensity of movement-evoked field 1 (MEF1) between 16 MZ twins and 16 pairs of genetically unrelated pairs. Differences in latency and dipole location between MZ twins were significantly less than those between unrelated age-matched pairs. However, amplitude and dipole intensity were not significantly different. These results suggest that the latency and dipole location of MEF1 are determined early in life by genetic and early common environmental factors, whereas amplitude and dipole intensity are influenced by long-term environmental factors. Improved understanding of genetic and environmental factors that influence cerebral motor function may contribute to evaluation and improvement for individual motor function.

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“…A comparison of EEGs in twins demonstrated that much of the variance in EEG power during the resting state is explained by genetic factors 17 . Similarly, MEG studies involving twins demonstrated that genetic factors have a large effect on MEG responses during somatosensory 18 and motor tasks 19 .…”

Section: Introductionmentioning

confidence: 94%

Frequency-specific genetic influence on inferior parietal lobule activation commonly observed during action observation and execution

Araki

Onishi

Yanagisawa

et al. 2017

Sci Rep

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Brain activity relating to recognition of action varies among subjects. These differences have been hypothesised to originate from genetic and environmental factors although the extent of their effect remains unclear. Effects of these factors on brain activity during action recognition were evaluated by comparing magnetoencephalography (MEG) signals in twins. MEG signals of 20 pairs of elderly monozygotic twins and 11 pairs of elderly dizygotic twins were recorded while they observed finger movements and copied them. Beamformer and group statistical analyses were performed to evaluate spatiotemporal differences in cortical activities. Significant event-related desynchronisation (ERD) of the β band (13–25 Hz) at the left inferior parietal lobule (IPL) was observed for both action observation and execution. Moreover, β-band ERD at the left IPL during action observation was significantly better correlated among monozygotic twins compared to unrelated pairs (Z-test, p = 0.027). β-band ERD heritability at the left IPL was 67% in an ACE model. These results demonstrate that β-band ERD at the IPL, which is commonly observed during action recognition and execution, is affected by genetic rather than environmental factors. The effect of genetic factors on the cortical activity of action recognition may depend on anatomical location and frequency characteristics.

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Genetic influence demonstrated for MEG-recorded somatosensory evoked responses

Cited by 5 publications

References 25 publications

Adding dynamics to the Human Connectome Project with MEG

Adding dynamics to the Human Connectome Project with MEG

Genetic and Environmental Influences on Motor Function: A Magnetoencephalographic Study of Twins

Frequency-specific genetic influence on inferior parietal lobule activation commonly observed during action observation and execution

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