Genetic influence of growth and differentiation factor 5 gene polymorphism (+104T/C) on the development of knee osteoarthritis and its association with disease severity

Mi, Abd Elazeem; Ea, Abdelaleem; Ra, Mohamed

doi:10.5152/eurjrheum.2017.160093

Cited by 15 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mervat et al [28] conducted a case–control study in Egypt populations, and no statistically significant association was detected on comparing the frequency distribution of allele and genotype frequencies of the SNP in patients and healthy controls. But the results of this study revealed a possible genetic association between GDF5 (+104T/C) SNP and the severity of KOA, which might be of benefit for the detection of patients with a high risk for disease progression [29]. These studies above have some limitations such as small sample size, and mixed study population with different OA.…”

Section: Discussionmentioning

confidence: 96%

Interaction between GDF5 gene polymorphisms and environment factors increased the risk of knee osteoarthritis: a case–control study

Zhang

Wang

et al. 2019

Bioscience Reports

View full text Add to dashboard Cite

Using a case–control design, we assessed the association between single nucleotide polymorphisms (SNPs) of growth and differentiation factor 5 (GDF5)/rs143383 gene and interaction with environments and knee osteoarthritis (KOA). We recruited 288 KOA patients from the First Clinical College, Henan University of Chinese Medicine between June 2017 and May 2018. There was significant difference in genotype distribution between case group and control group (χ2 = 22.661, P=0.000). The minor C allele was significantly higher in the case group than that in the control group (20.5 vs 8.1%, P=0.000, odds ratio (OR) = 1.62, 95% confidence interval (CI): 1.29–2.03). Significant differences were also observed in other gene models. For age, all models show significant differences (P<0.05) for those whose age was more than 60 years, and no significant difference was observed for those under 60 years. For non-smoking group, there were significant differences between case group and control group, and for smoker, significance level was found in TT compared with CC and allele gene models. Patients with drinking and Bbody mass index (MI )≥ 24 also showed significant relationship between rs143383 and osteoarthritis (OA) under the following models: TT vs CC (P=0.000, P=0.018), TT/CT vs CC (P=0.043), TT vs CT/CC (P=0.000, P=0.009), and T vs C (P=0.024, P=0.000). Other gene models indicated no significance (P>0.05). Our results revealed a possible genetic association between GDF5 and KOA, and the TT genotype of rs143383 increased the risk of KOA in Chinese Han population. The interaction between GDF5 gene and drinking, smoking, and obesity further increased the risk of KOA.

show abstract

Section: Discussionmentioning

confidence: 96%

Interaction between GDF5 gene polymorphisms and environment factors increased the risk of knee osteoarthritis: a case–control study

Zhang

Wang

et al. 2019

Bioscience Reports

View full text Add to dashboard Cite

show abstract

“…35 The rs144383 (+104 T > C) C to T SNP located in the 5ʹUTR of GDF-5 gene, has been studied intensively. 24,30 Previously published studies have indicated a significant association between GDF-5 rs143383 polymorphism and OA risk. However, the conclusions are still inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…Of the remaining 97 studies, we further removed 80 articles due to reviews articles, case reports, case-only design, and insufficient data to calculate ORs. Finally, 17 case-control studies in 14 publications [19][20][21][22][23][24][25][26][27][28][29][30][31][32] with 7424 cases and 11,310 controls were included in the meta-analysis. The detailed characteristics of the included studies were summarized in Table 1.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis: A systematic review and meta-analysis

Aghili

Sobhan

Mehdinezhad-Yazdi

et al. 2018

Journal of Orthopaedics

View full text Add to dashboard Cite

show abstract

“…Sixteen articles [5,11,[15][16][17][18][19][20][21][22][23][24][25][26][27][28], including separate 20 studies (7997 cases and 12,684 controls), finally have been collected in the meta-analysis from 196 studies, which process is showed in Fig. 1.…”

Section: Studies Extraction and Characteristics Of Studiesmentioning

confidence: 99%

Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis

Peng

Jin

et al. 2020

Arthritis Res Ther

View full text Add to dashboard Cite

Background A few months ago, the Bioscience Reports journal showed that growth differentiation factor 5 (GDF5) rs143383 genetic polymorphism increases the susceptibility of knee osteoarthritis (KOA), but previous studies’ results have debates about available data. Considering the availability of more recent data, we focus on clarifying the relationship of KOA and GDF5 rs143383 genetic polymorphism by a meta-analysis of case-control trial data. Methods The eligible studies from the time of database established to Oct. 2019 were collected from PubMed, Springer, Cochrane library, Web of Science, China National Knowledge Infrastructure (CNKI), and Wan Fang library. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate the association between these polymorphisms and KOA risk. The meta-analysis was completed by STATA 18.0 software. Results A total of 196 studies were collected, 16 of them included in final meta-analysis (7997 cases and 12,684 controls). There was significant association between GDF5 rs143383 polymorphism and KOA in all genetic models (for Allele model (C versus T): OR = 0.84 (95% CI = 0.76–0.91); dominate model (CC+CT versus TT): OR = 0.80 (95% CI = 0.72–0.90); recessive model (CC versus CT+TT): OR = 0.79 (95% CI = 0.68–0.92); heterozygote model (CT versus CC+TT): OR = 0.89 (95% CI = 0.80–0.97); homozygous model (CC versus TT): OR = 0.71 (95% CI = 0.60–0.85)). In the subgroup analysis, we obtained the results that there is no significance among Asians. Conclusion GDF5 rs143383 genetic polymorphism increases the risk of KOA among Caucasians; CC genotype and C allele are protective factors for the susceptibility of KOA among Caucasians.

show abstract

Genetic influence of growth and differentiation factor 5 gene polymorphism (+104T/C) on the development of knee osteoarthritis and its association with disease severity

Cited by 15 publications

References 27 publications

Interaction between GDF5 gene polymorphisms and environment factors increased the risk of knee osteoarthritis: a case–control study

Interaction between GDF5 gene polymorphisms and environment factors increased the risk of knee osteoarthritis: a case–control study

Association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis: A systematic review and meta-analysis

Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis

Contact Info

Product

Resources

About