Genetic influence on cytokine production and fatal meningococcal disease

Westendorp, Rudi G.J.; Langermans, Jan A. M.; Huizinga, Tom W J; Elouali, Abdul H.; Verweij, Cornelis L.; Boomsma, Dorret I.; Vandenbrouke, Jan P.

doi:10.1016/s0140-6736(96)06413-6

Cited by 736 publications

(487 citation statements)

References 17 publications

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“…6 Another recent report supports the hypothesis that IL-10 protein production is largely under genetic control by showing that heritability in monozygotic twins is 0.75 for the production of IL-10. 7 All these observations emphasise the need for an efficient PCR system, capable of identifying those patients or transplant recipients carrying IL-10 haplo- Table 4 The sequences of the primers used in PCR-SSP method developed to analyse IL-10 promoter polymorphisms. C1 and C2 are control primers specific for exon 3 sequences in HLA-B which were used for HLA phototyping 4 …”

Section: Discussionmentioning

confidence: 99%

Interleukin-10 gene promoter polymorphism in English and Polish healthy controls. Polymerase chain reaction haplotyping using 3′ mismatches in forward and reverse primers

Koss

Fanning

et al. 2000

Genes Immun

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A polymerase chain reaction with sequence-specific primers (PCR-SSP) system using primers with mismatches at the 3 ′ ends was developed to determine polymorphisms in IL-10 promoter region. Three previously described biallelic polymorphisms in IL-10 were linked in a 12 reaction PCR-SSP system and the method used to provide genotype data on 233 UK and 166 Polish controls. There are eight possible polymorphic combinations in IL-10 promoter gene but only three were observed in both control groups. Population frequencies of IL-10 genotypes show, in contrast to HLA, that UK and Polish frequencies are remarkably similar. Genes and Immunity (2000) 1, 321-324.

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Section: Discussionmentioning

confidence: 99%

Interleukin-10 gene promoter polymorphism in English and Polish healthy controls. Polymerase chain reaction haplotyping using 3′ mismatches in forward and reverse primers

Koss

Fanning

et al. 2000

Genes Immun

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“…To date, however, no single polymorphism (or group of polymorphisms) has been able to explain predisposition toward this phenotype. The importance of this issue was highlighted by the work of Westendorp et al who, in 1997, examined the ex vivo LPS-induced cytokine production capacity of 190 first degree relatives of patients with invasive meningococcal disease [59]. They found that family members of nonsurvivors produced less TNFα and more IL-10 upon ex vivo LPS stimulation than did the relatives of patients who survived, indicating that a predilection towards an anti-inflammatory phenotype may be heritable.…”

Section: Mechanisms Of Immunoparalysismentioning

confidence: 99%

Immunoparalysis and Adverse Outcomes from Critical Illness

Frazier

Hall

2008

Pediatric Clinics of North America

134

108

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“…In an important paper, Westendorp et al 9 showed that the levels of both TNF and IL-10 in firstdegree relatives of patients with meningococcal disease strongly determined the likelihood of patient survival. They also showed a strong concordance of TNF levels in monozygotic twins.…”

Section: Introductionmentioning

confidence: 99%

Is there a future for TNF promoter polymorphisms?

2004

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The in vitro study of TNF promoter polymorphism (SNP) function was stimulated by the numerous case-control (association) studies of the polymorphisms in relation to human disease and the appearance of several studies claiming to show a functional role for these SNPs provided a further impetus to researchers interested in the role of TNF in their disease of interest. In this review we consider case-control studies, concentrating on the autoimmune and inflammatory diseases rheumatoid arthritis, multiple sclerosis, ankylosing spondylitis, and asthma, and on infectious diseases including malaria, hepatitis B and C infection, leprosy and sepsis/septic shock. We also review the available evidence on the functional role of the various TNF promoter polymorphisms. In general, case-control studies have produced mixed results, with little consensus in most cases on whether any TNF polymorphisms are actually associated with disease, although results have been more consistent in the case of infectious diseases, particularly malaria. Functional studies have also produced mixed results but recent work suggests that the much studied À308G/A polymorphism is not functional, while the function of other TNF polymorphisms remains controversial. Studies of the TNF region are increasingly using extended haplotypes that can better capture the variation of the MHC region.

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Genetic influence on cytokine production and fatal meningococcal disease

Cited by 736 publications

References 17 publications

Interleukin-10 gene promoter polymorphism in English and Polish healthy controls. Polymerase chain reaction haplotyping using 3′ mismatches in forward and reverse primers

Interleukin-10 gene promoter polymorphism in English and Polish healthy controls. Polymerase chain reaction haplotyping using 3′ mismatches in forward and reverse primers

Immunoparalysis and Adverse Outcomes from Critical Illness

Is there a future for TNF promoter polymorphisms?

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