Genetic influence on the associations between IGF-I and glucose metabolism in a cohort of elderly twins

Jensen, Rikke Beck; Thankamony, Ajay; Holst, Klaus K.; Janssen, Joseph A M J L; Juul, Anders; Poulsen, Pernille; Scheike, Thomas

doi:10.1530/eje-17-0754

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…We compared the heritability of serum IGF-I to the heritability of PAPP-A, STC2 and IGF-II, and we used serum IGF-I to assess whether our cohort in an IGF-system context was comparable to other cohorts of elderly subjects. The present heritability index of IGF-I was in agreement with a recent study by Jensen et al, who found a heritability index of 65% using the same IGF-I assay in a different cohort of Danish twins (22). As regards the age relationship and sex difference of serum IGF-I concentrations in elderly people, our results agreed with some previous findings, but not all (25, 53-55).…”

Section: Discussionsupporting

confidence: 93%

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Heritability and circulating concentrations of pregnancy-associated plasma protein-A and stanniocalcin-2 in elderly monozygotic and dizygotic twins

et al. 2023

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IntroductionPregnancy-associated plasma protein-A (PAPP-A) is an IGF-activating enzyme suggested to influence aging-related diseases. However, knowledge on serum PAPP-A concentration and regulation in elderly subjects is limited. Therefore, we measured serum PAPP-A in elderly same-sex monozygotic (MZ) and dizygotic (DZ) twins, as this allowed us to describe the age-relationship of PAPP-A, and to test the hypothesis that serum PAPP-A concentrations are genetically determined. As PAPP-A is functionally related to stanniocalcin-2 (STC2), an endogenous PAPP-A inhibitor, we included measurements on STC2 as well as IGF-I and IGF-II.MethodsThe twin cohort contained 596 subjects (250 MZ twins, 346 DZ twins), whereof 33% were males. The age ranged from 73.2 to 94.3 (mean 78.8) years. Serum was analyzed for PAPP-A, STC2, IGF-I, and IGF-II by commercial immunoassays.ResultsIn the twin cohort, PAPP-A increased with age (r=0.19; P<0.05), whereas IGF-I decreased (r=-0.12; P<0.05). Neither STC2 nor IGF-II showed any age relationship. When analyzed according to sex, PAPP-A correlated positively with age in males (r=0.18; P<0.05) and females (r=0.25; P<0.01), whereas IGF-I correlated inversely in females only (r=-0.15; P<0.01). Males had higher levels of PAPP-A (29%), STC2 (18%) and IGF-I (19%), whereas serum IGF-II was 28% higher in females (all P<0.001). For all four proteins, within-pair correlations were significantly higher for MZ twins than for DZ twins, and they demonstrated substantial and significant heritability, which after adjustment for age and sex averaged 59% for PAPP-A, 66% for STC2, 58% for IGF-I, and 52% for IGF-II.DiscussionThis twin study confirms our hypothesis that the heritability of PAPP-A serum concentrations is substantial, and the same is true for STC2. As regards the age relationship, PAPP-A increases with age, whereas STC2 remains unchanged, thereby supporting the idea that the ability of STC2 to inhibit PAPP-A enzymatic activity decreases with increasing age.

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Section: Discussionsupporting

confidence: 93%

“…To generate such data, we capitalized on our access to a very well characterized cohort of Danish dizygotic (DZ) and monozygotic (MZ) twins (19). To evaluate PAPP-A and STC2 in an IGF context, we also studied the heritability and agedependency of IGF-I and IGF-II (20)(21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Heritability and circulating concentrations of pregnancy-associated plasma protein-A and stanniocalcin-2 in elderly monozygotic and dizygotic twins

et al. 2023

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“…selected groups of patients. Jensen et al showed a strong negative correlation between IGF-1 and insulin sensitivity, which does not seem to be genetically determined (12). Lower levels of IGF-1 were also confi rmed in patients with non-alcoholic fatty liver disease (13,14).…”

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confidence: 97%

Insulin-like growth factor (IGF) system and hormonal-metabolic profile in women with polycystic ovary syndrome

Lazúrová¹,

Figurová²,

Lazurova³

et al. 2021

BLL

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AIM of the study was to compare serum levels of IGF-1, IGF-2 and insulin-like growth factor-binding protein 3 (IGFBP-3) among non-obese and obese PCOS women, and to assess their relationship to metabolic and hormonal parameters. METHODS: The study included 64 women diagnosed with PCOS (age 28.9 ± 5 years); 30 of them with BMI > 27 and 34 with BMI lower than 27. All subjects were examined for parameters of glucose and lipid metabolism, steroid hormones and serum IGF-1, IGF-2 and IGFBP-3 levels. RESULTS: No signifi cant differences in serum IGFBP-3 (p=0.534), IGF-1 (p=0.29) and IGF-2 (p=0.56) between two groups have been detected. IGFBP-3 was in positive correlation with total cholesterol (p=0.026), LDL cholesterol (p=0.03) and triacylglycerols (p=0.022). IGF-1 were negatively correlated with insulin (p=0.022), HOMA IR (p=0.033), triacylglycerols (p=0.0196) and waist circumference (p=0.049). A positive correlation was detected between IGF-1 and HDL cholesterol (p=0.025). No signifi cant relationship was observed between IGF-1 and steroid hormones. CONCLUSION: Serum levels of IGF-1, IGF-2 and IGFBP-3 in obese PCOS women do not differ from those detected in non-obese PCOS women. IGF-1 negatively correlated with metabolic parameters, indicating that lower IGF-1 may represent an important predictor of metabolic syndrome (MS) in PCOS women. All peptides seem to have little effect on ovarian steroidogenesis in PCOS (Tab. 1, Fig. 1, Ref. 30).

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Association of IGF1 and VEGFA polymorphisms with diabetic retinopathy in Pakistani population

et al. 2019

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Genetic influence on the associations between IGF-I and glucose metabolism in a cohort of elderly twins

Cited by 4 publications

References 40 publications

Heritability and circulating concentrations of pregnancy-associated plasma protein-A and stanniocalcin-2 in elderly monozygotic and dizygotic twins

Heritability and circulating concentrations of pregnancy-associated plasma protein-A and stanniocalcin-2 in elderly monozygotic and dizygotic twins

Insulin-like growth factor (IGF) system and hormonal-metabolic profile in women with polycystic ovary syndrome

Association of IGF1 and VEGFA polymorphisms with diabetic retinopathy in Pakistani population

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