Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies

Goldberg, Lisa R.; Gould, Thomas J.

doi:10.1016/j.brainresbull.2022.06.007

Cited by 6 publications

(2 citation statements)

References 149 publications

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“…Emerging evidence from multiple fields of biology demonstrates that the impact of environmental exposures may extend well beyond the directly exposed individuals and manifest in multiple generations descending from the directly exposed individuals [1][2][3][4][5] . Much of the research on this topic is focused on deleterious effects produced by exposure to psychosocial stress, natural calamities such as famine, or to substances such as endocrine disrupting agents, hormones and drugs of abuse [1][2][3][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] . However, millions of individuals are exposed daily to substances declared "safe" by regulatory agencies based on evaluation of effects in individuals directly exposed to the substances as adults or exposed prenatally.…”

Section: Introductionmentioning

confidence: 99%

Learning and memory deficits produced by aspartame are heritable via the paternal lineage

Jones

McCarthy

Stanwood

et al. 2023

Preprint

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Environmental exposures produce heritable traits that can linger in the population for one or two generations. Millions of individuals consume substances such as artificial sweeteners daily that are declared safe by regulatory agencies without evaluation of their potential heritable effects. We show that consumption of aspartame, an FDA-approved artificial sweetener, daily for up to 16-weeks at doses equivalent to only 7-15% of the FDA recommended maximum daily intake value (equivalent to 2-4 small, 8 oz diet soda drinks per day) produces significant spatial learning and memory deficits in mice. Moreover, the cognitive deficits are transmitted to male and female descendants along the paternal lineage suggesting that aspartame’s adverse cognitive effects are heritable, and that they are more pervasive than current estimates, which consider effects in the directly exposed individuals only. Traditionally, deleterious environmental exposures of pregnant and nursing women are viewed as risk factors for the health of future generations. Environmental exposures of men are not considered to pose similar risks. Our findings suggest that environmental exposures of men can produce adverse impact on mental health of future generations and demonstrate the need for considering heritable effects via the paternal lineage as part of the regulatory evaluations of artificial sweeteners.

show abstract

Section: Introductionmentioning

confidence: 99%

Learning and memory deficits produced by aspartame are heritable via the paternal lineage

Jones

McCarthy

Stanwood

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Our findings suggest that environmental exposures of men can produce adverse impact on cognitive function in future generations and demonstrate the need for considering heritable effects via the paternal lineage as part of the regulatory evaluations of artificial sweeteners.Emerging evidence from multiple fields of biology demonstrates that the impact of environmental exposures may extend well beyond the directly exposed individuals and manifest in multiple generations descending from the directly exposed individuals [1][2][3][4][5] . Much of the research on this topic is focused on deleterious effects produced by exposure to psychosocial stress, natural calamities such as famine, or to substances such as endocrine disrupting agents, hormones and drugs of abuse [1][2][3][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] . However, millions of individuals are exposed daily to substances declared "safe" by regulatory agencies based on evaluation of effects in individuals directly exposed to the substances as adults or exposed prenatally.…”

mentioning

confidence: 99%

Learning and memory deficits produced by aspartame are heritable via the paternal lineage

Jones,

McCarthy,

Stanwood

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Environmental exposures produce heritable traits that can linger in the population for one or two generations. Millions of individuals consume substances such as artificial sweeteners daily that are declared safe by regulatory agencies without evaluation of their potential heritable effects. We show that consumption of aspartame, an FDA-approved artificial sweetener, daily for up to 16-weeks at doses equivalent to only 7–15% of the FDA recommended maximum daily intake value (equivalent to 2–4 small, 8 oz diet soda drinks per day) produces significant spatial learning and memory deficits in mice. Moreover, the cognitive deficits are transmitted to male and female descendants along the paternal lineage suggesting that aspartame’s adverse cognitive effects are heritable, and that they are more pervasive than current estimates, which consider effects in the directly exposed individuals only. Traditionally, deleterious environmental exposures of pregnant and nursing women are viewed as risk factors for the health of future generations. Environmental exposures of men are not considered to pose similar risks. Our findings suggest that environmental exposures of men can produce adverse impact on cognitive function in future generations and demonstrate the need for considering heritable effects via the paternal lineage as part of the regulatory evaluations of artificial sweeteners.

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Nikotin

2025

Suchtmedizin

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Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies

Cited by 6 publications

References 149 publications

Learning and memory deficits produced by aspartame are heritable via the paternal lineage

Learning and memory deficits produced by aspartame are heritable via the paternal lineage

Learning and memory deficits produced by aspartame are heritable via the paternal lineage

Nikotin

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