Genetic influences on bone loss in the San Antonio Family Osteoporosis study

Shaffer, John R.; Kammerer, Candace M.; Bruder, Jan M.; Cole, Shelley A.; Dyer, Thomas D.; Almasy, Laura; MacCluer, Jean W.; Blangero, John; Bauer, Richard L.; Mitchell, Braxton D.

doi:10.1007/s00198-008-0616-0

Cited by 18 publications

(22 citation statements)

References 39 publications

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“…While it is well established that peak bone mass is highly heritable [30][31][32], there is little published data on heritability of bone loss [33][34][35][36]. Studies that attempted to evaluate the genetic contribution to bone loss were often unsuccessful due to the inherent difficulty to measure a rate [36,37].…”

Section: Discussionmentioning

confidence: 97%

UGT2B17 gene deletion associated with an increase in bone mineral density similar to the effect of hormone replacement in postmenopausal women

et al. 2011

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Section: Discussionmentioning

confidence: 97%

UGT2B17 gene deletion associated with an increase in bone mineral density similar to the effect of hormone replacement in postmenopausal women

et al. 2011

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“…(9) A study in peri-and postmenopausal women followed for 1 to 10 years showed a significant heritability for BMD changes in lumbar spine and forearm but not in the hip area. (10) In another familybased study, Shaffer and colleagues (11) reported a significant heritable component to bone loss at the spine (42%), total hip (44%), and distal radius (25%) in Mexican-American families. In a previous smaller study on 712 female twins aged >40 years from the TwinsUK cohort, we found a significant genetic influence on bone loss at different anatomical sites including the femoral neck.…”

Section: Introductionmentioning

confidence: 99%

Effects of age on genetic influence on bone loss over 17 years in women: The Healthy Ageing Twin Study (HATS)

Moayyeri

Hammond

Hart

et al. 2012

Journal of Bone and Mineral Research

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The rate of bone loss varies across the aging period via multiple complex mechanisms. Therefore, the role of genetic factors on bone loss may also change similarly. In this study, we investigated the effect of age on the genetic component of bone loss in a large twin-based longitudinal study. During 17 years of follow-up in TwinsUK and Healthy Ageing Twin Study (HATS), 15,491 hip and lumbar spine dualenergy X-ray absorptiometry (DXA) scans were performed in 7056 twins. Out of these subjects, 2716 female twins aged >35 years with at least two scans separated for >4 years (mean follow-up 9.7 years) were included in this analysis. We used a mixed-effects randomcoefficients regression model to predict hip and spine bone mineral density (BMD) values for exact ages of 40, 45, 50, 55, 60, 65, 70, 75, and 80 years, with adjustment for baseline age, weight, height, and duration of hormone replacement therapy. We then estimated heritability of the changes in BMD measures between these age ranges. Heritability estimates for cross-sectional hip and spine BMD were high (ranging between 69% and 88%) at different ages. Heritability of change of BMD was lower and more variable, generally ranging from 0% to 40% for hip and 0% to 70% for spine; between age 40 and 45 years genetic factors explained 39.9% (95% confidence interval [CI], 25%-53%) of variance of BMD loss for total hip, 46.4% (95% CI, 32%-58%) for femoral neck, and 69.5% (95% CI, 59%-77%) for lumbar spine. These estimates decreased with increasing age, and there appeared to be no heritability of BMD changes after the age of 65 years. There was some evidence at the spine for shared genetic effects between cross-sectional and longitudinal BMD. Whereas genetic factors appear to have an important role in bone loss in early postmenopausal women, nongenetic mechanisms become more important determinants of bone loss with advanced age. ß

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“…Other, non-measured lifestyle risk factors, including vocation, physical activity, diet, and adolescent environment may be involved. Likewise, studies in this population [9, 10] and others [14, 15] indicate that genetics plays a large role in bone loss, and gene-by-sex interactions may contribute to the observed differences between young men and women.…”

Section: Discussionmentioning

confidence: 78%

“…Data collection for the baseline (calendar years 1997 to 2000) and follow-up (2003 to 2006) phases of the San Antonio Family Osteoporosis Study (SAFOS) have been previously described in detail [8-10]. Participants were recruited through a house-to-house recruitment protocol that identified probands meeting two eligibility criteria: (I) being between 40 to 60 years of age; and (II) having large families in the San Antonio area.…”

Section: Methodsmentioning

confidence: 99%

“…A concurrent update in software was applied to ensure comparability of scoring algorithms between models. Extensive cross-calibration of equipment has been previously described [10]. In brief, duplicate measures of a sample of subjects recorded from the two densitometers showed near-perfect agreement (R 2 > 99.8%, p<10 -13 ) and no mean differences (paired t-test p>0.1) for several bone sites of the proximal femur and spine.…”

Section: Methodsmentioning

confidence: 99%

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Rate of bone loss is greater in young Mexican American men than women: The San Antonio Family Osteoporosis Study

Shaffer

Kammerer

Dressen

et al. 2010

Bone

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Little is known about the progression of bone loss during young adulthood and whether it differs between men and women. As part of the San Antonio Family Osteoporosis Study we tested whether bone mineral density (BMD) changed over time in men or women, and whether the rate of BMD change differed between the sexes. BMD of the proximal femur, spine, radius, and whole body was measured in 115 men and 202 pre-menopausal women (ages 25 to 45 years; Mexican American ancestry) by dual-energy x-ray absorptiometry at two time points (5.6 years apart), from which annual percent change-in-BMD was calculated. Likelihood-based methods were used to test whether change-in-BMD differs from zero or differs between men and women. In men, percent change-in-BMD was significantly greater than zero for the 1/3 radius (i.e. indicating a gain of BMD; Bonferroniadjusted p < 0.01), less than zero for the femoral neck, lumbar spine, ultradistal radius, and whole body (i.e. indicating a loss of BMD; p < 0.01 for all), and not different than zero for the total hip (p = 0.24). In women, percent change-in-BMD was greater than zero for the total hip, 1/3 radius, and whole body (p < 0.01 for all), less than zero for the ultradistal radius (p < 0.01), and not significantly different than zero for the femoral neck and lumbar spine (p = 1.0 for both). For all skeletal sites, men experienced greater decrease in BMD (or less increase in BMD) than women; this result was observed both with and without adjustment for age, BMI, and change-in-BMI (p < 0.05 for all). These results suggest that significant bone loss occurs at some skeletal sites in young men and women, and that loss of BMD is occurring significantly faster, or gain of BMD is occurring significantly slower, in young men compared to young women.

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Genetic influences on bone loss in the San Antonio Family Osteoporosis study

Cited by 18 publications

References 39 publications

UGT2B17 gene deletion associated with an increase in bone mineral density similar to the effect of hormone replacement in postmenopausal women

UGT2B17 gene deletion associated with an increase in bone mineral density similar to the effect of hormone replacement in postmenopausal women

Effects of age on genetic influence on bone loss over 17 years in women: The Healthy Ageing Twin Study (HATS)

Rate of bone loss is greater in young Mexican American men than women: The San Antonio Family Osteoporosis Study

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