Genetic influences on outcome following acute neurological insults

Waters, Ryan; Nicoll, James A. R.

doi:10.1097/01.ccx.0000155354.78617.91

Cited by 50 publications

(30 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The potential role of ApoE in the repair and regeneration of neurons and survival after brain injury was found in rodent models of head injury and ischaemic stroke (Graham et al 1999;Horsburgh et al 2000). Clinical studies have shown that genotypes with the e 4 allele are associated with poor outcome after head injury (Waters and Nicoll 2005). According to these observations, it can be suggested that ApoE might influence outcome after acute stroke in humans (Waters and Nicoll 2005).…”

Section: Discussionmentioning

confidence: 96%

“…Clinical studies have shown that genotypes with the e 4 allele are associated with poor outcome after head injury (Waters and Nicoll 2005). According to these observations, it can be suggested that ApoE might influence outcome after acute stroke in humans (Waters and Nicoll 2005). Since different studies have produced conflicting results, there was the necessity of the conducting of a comprehensive meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis

2006

View full text Add to dashboard Cite

Stroke is a heterogeneous multifactorial disease and is thought to have a polygenic basis. Casecontrol studies on gene sequence variations have identified a number of potential genetic predisposition factors, but due to the conflicting results, uncertainty remains on the effect of these polymorphisms on risk for the development of stroke. To qualitatively and quantitatively assess the risk associated with different gene polymorphisms for stroke in Asian populations, we comprehensively searched and identified all the studies of association. Clinically overt case-control studies were selected only if neuroimaging had been used as the confirmatory measure for diagnosis of stroke. We performed a meta-analysis of the three most investigated genes, viz., methylenetetrahydrofolate reductase (MTHFR), apolipoprotein E (ApoE) and angiotensinconverting enzyme (ACE). Statistically significant association with stroke were identified for C677T polymorphism of MTHFR [random effects odds ratio (OR) = 1.47, 95% confidence interval (95% CI) 1.19, 1.82; P = 0.0004] and marginally significant association was detected with allele e 4 of ApoE (random effects OR = 1.47, 95% CI 1.00, 2.15; P = 0.049). The sensitivity analysis (exclusion of studies with controls not in HardyWeinberg equilibrium) revealed a significant association of stroke with the MTHFR C677T and ApoE e 4 alleles but showed no association with ACE gene insertion/ deletion polymorphism.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis

2006

View full text Add to dashboard Cite

show abstract

“…32,87 Further, variability in the trajectories of the diffusion measures might be affected by differences in number of previous concussions, 68 timing of each athlete's return to play (see Table 1), and individual genetic predisposition. 88,89 Experimental designs of future studies should include the assessment of subconcussive hits, extending at least to the end of season.…”

Section: Longitudinal Dti Study Of Wm Tracts After Srcmentioning

confidence: 99%

A Longitudinal Diffusion Tensor Imaging Study Assessing White Matter Fiber Tracts after Sports-Related Concussion

Murugavel

Cubon

Putukian

et al. 2014

Journal of Neurotrauma

106

View full text Add to dashboard Cite

The extent of structural injury in sports-related concussion (SRC) is central to the course of recovery, long-term effects, and the decision to return to play. In the present longitudinal study, we used diffusion tensor imaging (DTI) to assess white matter (WM) fiber tract integrity within 2 days, 2 weeks, and 2 months of concussive injury. Participants were righthanded male varsity contact-sport athletes (20.2 -1.0 years of age) with a medically diagnosed SRC (no loss of consciousness). They were compared to right-handed male varsity non-contact-sport athletes serving as controls (19.9 -1.7 years). We found significantly increased radial diffusivity (RD) in concussed athletes (n = 12; paired t-test, tract-based spatial statistics; p < 0.025) at 2 days, when compared to the 2-week postinjury time point. The increase was found in a cluster of right hemisphere voxels, spanning the posterior limb of the internal capsule (IC), the retrolenticular part of the IC, the inferior longitudinal fasciculus, the inferior fronto-occipital fasciculus (sagittal stratum), and the anterior thalamic radiation. Post-hoc, univariate, between-group (controls vs. concussed), mixed-effects analysis of the cluster showed significantly higher RD at 2 days ( p = 0.002), as compared to the controls, with a trend in the same direction at 2 months ( p = 0.11). Results for fractional anisotropy (FA) in the same cluster showed a similar, but inverted, pattern; FA was decreased at 2 days and at 2 months postinjury, when compared to healthy controls. At 2 weeks postinjury, no statistical differences between concussed and control athletes were found with regard to either RD or FA. These results support the hypothesis of increased RD and reduced FA within 72 h postinjury, followed by recovery that may extend beyond 2 weeks. RD appears to be a sensitive measure of concussive injury.

show abstract

“…68,69 Apolipoprotein E is a key protein that plays an essential role in the repair of cell membrane and spread of neuritis following injury. 9,34,49 This protein is controlled by a gene with 3 primary alleles (e2, e3, and e4).…”

Section: Involvement Of Genetic Polymorphismsmentioning

confidence: 99%

Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction

Dubourg

Messerer

2011

FOC

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is recognized as a cause of hypopituitarism even after mild TBI. Although over the past decade, a growing body of research has detailed neuroendocrine changes induced by TBI, the mechanisms and risk factors responsible for this pituitary dysfunction are still unclear. Around the world, sports—especially combative sports—are very popular. However, sports are not generally considered as a cause of TBI in most epidemiological studies, and the link between sports-related head trauma and hypopituitarism has not been investigated until recently. Thus, there is a paucity of data regarding this important concern. Because of the large number of young sports participants with near-normal life expectancy, the implications of undiagnosed or untreated postconcussion pituitary dysfunction can be dramatic. Understanding the pathophysiological mechanisms and risk factors of hypopituitarism caused by sports injuries is thus an important issue that concerns both medical staff and sponsors of sports. The aim of this paper was to summarize the best evidence for understanding the pathophysiological mechanisms and to discuss the current data and recommendations on sports-related head trauma as a cause of hypopituitarism.

show abstract

Genetic influences on outcome following acute neurological insults

Cited by 50 publications

References 44 publications

Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis

Association of gene polymorphism with genetic susceptibility to stroke in Asian populations: a meta-analysis

A Longitudinal Diffusion Tensor Imaging Study Assessing White Matter Fiber Tracts after Sports-Related Concussion

Sports-related chronic repetitive head trauma as a cause of pituitary dysfunction

Contact Info

Product

Resources

About