2018
DOI: 10.1093/hmg/ddy395
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Genetic influences on susceptibility to rheumatoid arthritis in African-Americans

Abstract: Large meta-analyses of rheumatoid arthritis (RA) susceptibility in European (EUR) and East Asian (EAS) populations have identified >100 RA risk loci, but genome-wide studies of RA in African-Americans (AAs) are absent. To address this disparity, we performed an analysis of 916 AA RA patients and 1392 controls and aggregated our data with genotyping data from >100 000 EUR and Asian RA patients and controls. We identified two novel risk loci that appear to be specific to AAs: GPC5 and RBFOX1 (P AA < 5 × 10 −9). … Show more

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Cited by 66 publications
(45 citation statements)
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“…Also, various exonic VNTR maps within a very short distance of genome-wide significant loci associated with different GWAS studies. Examples are height ( ACAN locus 37 ), hair morphology ( TCHH locus 87 ), Asthma/Atopy ( FLG locus 88 , 89 ), Rheumatoid arthritis ( ICOSLG locus 90 ), and diastolic blood pressure ( HRCT1 locus 91 ). Future studies will have to indicate whether these VNTRs indeed explain at least part of the disease associations as identified in the respective GWAS studies.…”
mentioning
confidence: 99%
“…Also, various exonic VNTR maps within a very short distance of genome-wide significant loci associated with different GWAS studies. Examples are height ( ACAN locus 37 ), hair morphology ( TCHH locus 87 ), Asthma/Atopy ( FLG locus 88 , 89 ), Rheumatoid arthritis ( ICOSLG locus 90 ), and diastolic blood pressure ( HRCT1 locus 91 ). Future studies will have to indicate whether these VNTRs indeed explain at least part of the disease associations as identified in the respective GWAS studies.…”
mentioning
confidence: 99%
“…A. Ferreira et al, 2017;Kichaev et al, 2019;Laufer et al, 2019;Lessard et al, 2013). The second is HYOU1, which has been associated with BMI and Post-FEV1/FVC (Lutz et al, 2015;Pulit et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…The Consortium for the Longitudinal Evaluation of African‐Americans with Early Rheumatoid Arthritis (CLEAR) study was an observational case‐control study beginning in 2000 to investigate genetic influences on RA (Bridges et al, 2002; Laufer et al, 2019). Local IRB approval was obtained to use existing genotyping data from the Illumina Omni1S array on a subset of participants (625 RA cases and 879 controls) in this MR analysis.…”
Section: Real Data Analysismentioning
confidence: 99%