Genetic insights into cardiac relaxation and filling

Smith, Josh; Gidlöf, Olof

doi:10.1038/s44161-022-00052-6

Cited by 1 publication

(2 citation statements)

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“…For this purpose, utilizing them into nanoparticles (NPs) is attractive as these supramolecular assemblies usually enhance the delivery of various compounds to cells and tissue passively or actively and also reduce off target distribution aiming for diagnosis and therapy of many conditions such as cardiovascular diseases, central nervous system (CNS) diseases and cancers. [6][7][8][9] This review aims to elucidate how assembling these molecules into NPs has helped employ dyes for biomedical applications in vivo.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the interesting biomedical potential dyes possess, efforts have been made to optimize the administration of these compounds. For this purpose, utilizing them into nanoparticles (NPs) is attractive as these supramolecular assemblies usually enhance the delivery of various compounds to cells and tissue passively or actively and also reduce off target distribution aiming for diagnosis and therapy of many conditions such as cardiovascular diseases, central nervous system (CNS) diseases and cancers 6–9 …”

Section: Introductionmentioning

confidence: 99%

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Supramolecular dye nanoassemblies for advanced diagnostics and therapies

Ramezani,

De Smedt,

Sauvage

2024

Bioengineering & Transla Med

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Dyes have conventionally been used in medicine for staining cells, tissues, and organelles. Since these compounds are also known as photosensitizers (PSs) which exhibit photoresponsivity upon photon illumination, there is a high desire towards formulating these molecules into nanoparticles (NPs) to achieve improved delivery efficiency and enhanced stability for novel imaging and therapeutic applications. Furthermore, it has been shown that some of the photophysical properties of these molecules can be altered upon NP formation thereby playing a major role in the outcome of their application. In this review, we primarily focus on introducing dye categories, their formulation strategies and how these strategies affect their photophysical properties in the context of photothermal and non‐photothermal applications. More specifically, the most recent progress showing the potential of dye supramolecular assemblies in modalities such as photoacoustic and fluorescence imaging, photothermal and photodynamic therapies as well as their employment in photoablation as a novel modality will be outlined. Aside from their photophysical activity, we delve shortly into the emerging application of dyes as drug stabilizing agents where these molecules are used together with aggregator molecules to form stable nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%