Genetic instability in farmers using pesticides: A study in Brazil with analysis combining alkaline comet and micronucleus assays

Lucio, Fabiola Terra; Almeida, Igor Vivian de; Buzo, Matheus Gimenez; Vicentini, Verônica Elisa Pimenta

doi:10.1016/j.mrgentox.2023.503587

Cited by 2 publications

(1 citation statement)

References 47 publications

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“…The results are consistent with studies conducted on occupationally exposed subjects to organophosphorus and pyrethroid between 36-44 years old, such as flower growers, applicators, and formulators [10,15,16]. Conversely, the genotoxic potential of pesticides used for pest and vector control has been reported [4,5,7,17,18] Regarding lifestyle, 64.5% of those exposed and 84.8% of non-exposed practiced some type of physical activity; this difference was not significant (p = 0.06). Fruit consumption was higher in the non-exposed group (p = 0.04), and alcohol consumption was not different between the groups (p = 0.84).…”

Section: Discussionsupporting

confidence: 87%

Assessment of buccal mucosa genotoxicity in insecticide-exposed urban fumigators in Cali, Colombia

Londoño-Velasco,

Asencio-Santofimio,

Ortega-Avila

et al. 2024

Int J Occup Med Environ Health.

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This study aimed to evaluate cytogenetic damage in the buccal mucosa of non-exposed subjects (N = 33) and insecticide-exposed fumigators (N = 31) in the urban area of Cali, Colombia. Material and Methods: Through a questionnaire sociodemographic data, anthropometric measurements, state of health, and lifestyle were collected. Buccal micronucleus cytome (BMCyt) assay was using for evaluate cytogenetic damage. Results: The study showed that all fumigators used adequate personal protective equipment (PPE) and had low alcohol consumption. The authors did not find significant differences in BMCyt biomarkers between the groups (p > 0.05). Multivariate analysis showed a 13% increase in micronucleus (MN) frequency for every year of increasing age (OR = 1.13, p = 0.029), and higher MN with the decrease in daily fruit consumption (OR = 4.71, p = 0.084), without statistical significance. Conclusions: The results between groups could be related to healthy habits and PPE use among the subjects.

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