2017
DOI: 10.1038/s41537-017-0040-6
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Genetic interaction of DISC1 and Neurexin in the development of fruit fly glutamatergic synapses

Abstract: Originally identified at the breakpoint of a (1;11)(q42.1; q14.3) chromosomal translocation in a Scottish family with a wide range of mental disorders, the DISC1 gene has been a focus of intensive investigations as an entry point to study the molecular mechanisms of diverse mental dysfunctions. Perturbations of the DISC1 functions lead to behavioral changes in animal models, which are relevant to psychiatric conditions in patients. In this work, we have expressed the human DISC1 gene in the fruit fly (Drosophi… Show more

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Cited by 5 publications
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“…Neurexin-3 may be a potential target for the diseases mentioned above; however, compared with neurexin-1, more specific mechanisms of neurexin-3 at NMJs are still unknown. 17 , 18 …”
Section: The Function Of Neurexin-3mentioning
confidence: 99%