Genetic linkage studies in Alzheimer's disease

Abstract

We studied 18 families with Alzheimer's disease in family members, under the assumption that the disease is due to a single gene with an autosomal dominant form of inheritance. There was no evidence of linkage of Alzheimer's disease with any of 27 phenotypic gene markers analyzed, but close linkage for the Rh and MNS blood group loci was excluded.

Distribution of Cystine/Glutamate Exchange Transporter, System xc−, in the Mouse Brain

“…The human xCT is localized at chromosome 4q28 -31 (Sato et al, 2000). In this locus, the gene for glycophorin A is located, and a link with Alzheimer's disease has been suspected (Race, 1959), although close linkage of this gene with Alzheimer's disease has been excluded (Spence et al, 1986). In the cultured cells, the enhanced activity of system x c…”

Epigenomics of Alzheimer's Disease

“…[63][64] Finally, in rare and primarily early onset cases, the disease has been found to run in families in an autosomal dominant fashion. [65][66][67]…”

The genetics of alzheimer's disease

“…No evidence was found for linkage of HLA markers with Alzheimer's disease, and linkage with blood group markers Rh and MNs was excluded in North American pedigrees (Spence et al, 1986). Similarly, linkage to HLA and complement markers was excluded in European pedigrees (Clemenceau ef al., 1986).…”

“…The early studies suggesting an association between HLA, IgG and complement markers with Alzheimer's disease have been tested by several research groups in families. No evidence was found for linkage of HLA markers with Alzheimer's disease, and linkage with blood group markers Rh and MNs was excluded in North American pedigrees (Spence et al, 1986). Similarly, linkage to HLA and complement markers was excluded in European pedigrees (Clemenceau ef al., 1986).…”