Genetic markers anticipate response to citalopram in a majority of patients

Abstract

For the majority of the patients, genetic markers can be used to guide selection of citalopram. The rules identified in this study can help personalize prescription of antidepressants.

Textbook of Personalized Medicine

“…Data available through the Sequenced Treatment Alternatives to Relieve Depression database was used to create three boosted Classifi cation and Regression Trees to identify 16 subgroups of patients, among whom anticipation of positive or negative response to citalopram was signifi cantly different from 0.5 (Alemi et al 2011 ). In a 10-fold cross-validation, this ensemble of trees made no predictions in 33 % of cases.…”

Citalopram is less effective for patients with neurological disorder and/or post-traumatic stress disorder

“…One study found these markers work for patients with psychiatric disorders [28,29]. Another study found that genetic markers could accurately (78% correct) predict response in 2/3rd of cases but not all cases [30]. Others have tried to improve the precision of antidepressant selection by dividing depression into sub-types.…”