Genetic Modification of Alfalfa<i>(Medicago Sativa L.)</i>for Quality Improvement and Production of Novel Compounds

Vlahova, M.; Stefanova, Galina; Petkov, P.; Barbulova, Ani; Petkova, D.; Kalushkov, Plamen; Atanassov, A.

doi:10.1080/13102818.2005.10817286

Cited by 9 publications

(2 citation statements)

References 46 publications

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“…Recently, bio-pharming has been successfully used to produce a large number of important pharmaceuticals such as monoclonal antibodies and blood substitutes (Vlahova et al 2005). Transgenic alfalfa plant, expressing the VP1structural protein of the foot and mouth disease virus was found effective in inducing a virus-specific response in mice as edible/oral vaccine (Wigdorovitz et al 1999).…”

Section: Production Of Novel Compoundsmentioning

confidence: 99%

“…Glycosylation studies have shown that alfalfa is capable of producing recombinant glycoproteins with homogenous glycosylation patterns. Vlahova et al (2005) used transgenic alfalfa as a new expression system to produce recombinant human lactoferrin, an iron-binding glycoprotein active against a large number of pathogenic microorganisms with antiviral activity capable of inhibiting replication of a wide range of human and animal RNA and DNA viruses. Thus alfalfa may become a model system for molecular farming.…”

Section: Production Of Novel Compoundsmentioning

confidence: 99%

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Biotechnological advancements in alfalfa improvement

Kumar

2011

J Appl Genetics

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Review of biotechnology research in alfalfa shows that molecular techniques are extensively being used for basic and applied research toward alfalfa improvement. Biotechnological approaches have been used in two major areas, genomics and transgenics. In genomics, molecular markers, structural and functional genomics allowed identification of genes of interest and their regulatory components. Alfalfa being obstinate to genetic and genomic analysis, comparative genomics is used for molecular and genetic dissection of various plant processes in alfalfa. Alternatively, transgenic approach involves incorporation of specific and useful genes into alfalfa to improve the traits of interest. Input traits to improve agronomic performance and output traits to improve forage quality, or to produce novel industrial/pharmaceutical proteins, are the focus of current transgenic research in alfalfa. However, transgenic approach is controversial requiring cautious experimental design to combat bioisafety concerns. Ideally, forage alfalfa needs to possess more fermentable carbohydrates, proteins with balanced amino acid profile that degrade slower in rumen, improved winter hardiness, better water use efficiency, pest resistance and no anti-quality factors. Concerted efforts are required to bring together maximum of these characteristic features into the alfalfa plant.

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Section: Production Of Novel Compoundsmentioning

confidence: 99%

Section: Production Of Novel Compoundsmentioning

confidence: 99%

Biotechnological advancements in alfalfa improvement

Kumar

2011

J Appl Genetics

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Beneficial Uses of Genetically Modified Crops

Ford¹,

Bailey

Foster

2017

Encyclopedia of Life Sciences

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Genetically modified (GM) crops have now been under commercial production for over 20 years. They are grown on around 180 million hectares of land in 28 countries worldwide, and cultivation is dominated by four crops: maize, soya bean, cotton and canola. First‐generation herbicide‐tolerant and insect‐resistant GM crops have many quantifiable beneficial uses, including increasing crop yields and reducing pesticide use, to maximise outputs on currently available agriculture land while conferring a range of economic, environmental and human health benefits. Over the next few years, the increasing commercialisation of second‐generation GM crops with improved quality traits should produce similar benefits and contribute to the sustainable intensification of agriculture that is required to ensure global food security for future generations. Key Concepts Genetically modified crops have been cultivated commercially for over 20 years. Over 90% of GM crops grown are herbicide‐tolerant (HT) and insect‐resistant (IR) maize, soya bean, cotton and canola. GM crops produce yield gains of 22% on average, most indirectly via reduced losses with use of GM HT and IR crops. Pesticide use reduces by around 37% when GM crops are cultivated, saving around 583.5 million kilograms of pesticides during the period 1996–2014. Cultivation of GM crops provides profit increases of around 68% – equivalent to almost $18 billion every year. Commercialisation of HT and IR traits in other principal crops and the addition of quality traits should further increase yields and profits in the next decade.

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