Genetic Monitoring of the Thoroughbred Horse Breed on Loci of Dna Microsatellite

Храброва, Л. А.; Blohina, N. V.

doi:10.31043/2410-2733-2018-3-11-16

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This led to an increase in the inbreeding coefficient and level of homozygosity. The comparative analysis of the genetic diversity in groups of horses born in Russia and in imported horses showed that domestic stallions and mares had higher heterozygosity levels [29], which was confirmed by the genetic parameters of the breed in the period of 1990-2000.…”

Section: Discussionmentioning

confidence: 69%

Dynamics of the Inbreeding Coefficient and Homozygosity in Thoroughbred Horses in Russia

Kalashnikov

Храброва

Blohina

et al. 2020

Animals

View full text Add to dashboard Cite

The Thoroughbred (TB) horse has hugely impacted the development of horse breeding around the world. This breed has unique genetic qualities due to having had a closed studbook for approximately 300 years. In Russia, TBs have been bred since the second half of the 18th century. Here, we analyzed the genetic diversity and the inbreeding level in TB horses (n = 9680) for the period from 1990 to 2018 using polymorphisms of 17 microsatellite loci. We found that the genetic structure of the TB breed in Russia is represented by 100 alleles of panel STR (short tandem repeat) loci and has been stable for the past three decades. The conducted monitoring revealed a slight increase in the Wright’s inbreeding coefficient in all age and sex groups of TB horses (stallions, broodmares, and foals) from 0.68% to 0.90%, which was followed by a decrease in the degree of heterozygosity, Ho, from 68.5% to 67.6%. The Spearman’s rank correlation coefficient between the level of inbreeding and the degree of homozygosity was estimated (r = 0.022; p > 0.05). The obtained data on the DNA genotypes of horses of different breeds provide a unique base for the evaluation of genetic variability and the control of genetic variability of horses in selection programs.

show abstract

Section: Discussionmentioning

confidence: 69%

Dynamics of the Inbreeding Coefficient and Homozygosity in Thoroughbred Horses in Russia

Kalashnikov

Храброва

Blohina

et al. 2020

Animals

View full text Add to dashboard Cite

show abstract

“…Only minor differences from TB populations of foreign countries in the frequency of rare alleles were revealed (Jungwoo et al, 2014;Shelyov et al, 2014;Rukavina et al, 2016). The results of a comparative analysis of the genetic structure of different breeds show that the TB breed has its own pool of alleles that remains stable for generations (Khrabrova, 2008;Kalashnikov et al, 2011;Khrabrova, Blohina, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…генетика животных / animal genetics on the genetic structure of microsatellite loci is insignificant (Khrabrova, Blohina, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…The microsatellites are mainly localized in non-coding regions of the genome and are characterized by the codominant type of inheritance and a high polymorphic level. These universal markers are used for parentage verification, in genetic monito ring and population analyses (Wright, Bentzen, 1994;Bowling, Ruvinsky, 2000;Van de Goor et al, 2011;Khrabrova, Blohina, 2018).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of line differentiation in the Thoroughbred horse breed using DNA microsatellite loci

et al. 2019

Self Cite

View full text Add to dashboard Cite

The Thoroughbred (TB) horse is the best racehorse breed used in the racing industry. This breed has had a closed studbook for about 300 years. In Russia TB horses have been bred since the second half of the XVIII century. The modern Russian Stud Book register of TB horses is partially presented by stallions and broodmares imported from different countries. The genealogical structure of the breed is represented by 17 lines, among which the Northern Dancer line dominates (30.9 %). The study of features of different lines of TB was carried out on 17 loci of DNA microsatellites (VHL20, HTG4, AHT4, HMS7, HTG6, AHT5, HMS6, ASB23, ASB2, HTG10, HTG7, HMS3, HMS2, ASB17, LEX3, HMS1 and CA425) to assess genetic differentiation of the genealogical structure. The results of the DNA typing of 8091 Thoroughbred horses across microsatellite loci show that the gene pool of the domestic population is represented by 100 alleles typical of the breed. A comparative analysis of the genotypes of horses representing different lines indicates that they differ in the number of alleles (85–99), allele frequencies, the level of polymorphism Ae (2.93–3.48) and the degree of the observed heterozygosity Ho (0.653–0.739). The genetic distances between the lines varied in a wide range from 0.014 (Nasrullah – Northern Dancer) to 0.125 (Massine – Teddy). The correspondence to HWE was maintained in most lines, which is confirmed by the negative values of Fis. Cluster analysis demonstrated the correspondence of the obtained dendrogram of Nei’s genetic distances to its genealogical scheme of lines. Genetic differentiation of lines by index Fst varied in a range 0.005–0.073 at the mean value Fst = 0.024. The data indicate genetic differentiation of lines of TB at the STR markers and confirm the effectiveness of the system of linear breeding for the maintenance of interbreed biodiversity.

show abstract

The Genetic Structure of the Russian Horse Breed

Nikolaeva,

Voronkova,

Politova

et al. 2023

Russ J Genet

View full text Add to dashboard Cite

Genetic Monitoring of the Thoroughbred Horse Breed on Loci of Dna Microsatellite

Cited by 4 publications

References 0 publications

Dynamics of the Inbreeding Coefficient and Homozygosity in Thoroughbred Horses in Russia

Dynamics of the Inbreeding Coefficient and Homozygosity in Thoroughbred Horses in Russia

Assessment of line differentiation in the Thoroughbred horse breed using DNA microsatellite loci

The Genetic Structure of the Russian Horse Breed

Contact Info

Product

Resources

About