2009
DOI: 10.1158/0008-5472.can-09-0015
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Genetic Mutations Associated with Cigarette Smoking in Pancreatic Cancer

Abstract: Cigarette smoking doubles the risk of pancreatic cancer, and smoking accounts for 20% to 25% of pancreatic cancers. The recent sequencing of the pancreatic cancer genome provides an unprecedented opportunity to identify mutational patterns associated with smoking. We previously sequenced >750 million bp DNA from 23,219 transcripts in 24 adenocarcinomas of the pancreas (discovery screen). In this previous study, the 39 genes that were mutated more than once in the discovery screen were sequenced in an additiona… Show more

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Cited by 117 publications
(82 citation statements)
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“…Smoking is a well-established risk factor for pancreatic cancer and is associated with genetic alterations (21,33,34 ). A familial pancreatic cancer study showed that smokers develop pancreatic cancer a decade earlier than nonsmokers (35 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Smoking is a well-established risk factor for pancreatic cancer and is associated with genetic alterations (21,33,34 ). A familial pancreatic cancer study showed that smokers develop pancreatic cancer a decade earlier than nonsmokers (35 ).…”
Section: Discussionmentioning
confidence: 99%
“…However, some studies do not support these findings (34,38 ). One study reported that transition variants were 24% more common in smokers than in nonsmokers, and transversion variants were 53% more frequent in smokers (33 ). In lung cancer, G-to-T transversion in TP53 is a signature of DNA damage by tobacco smoke (39 ).…”
Section: Discussionmentioning
confidence: 99%
“…compared somatic mutations in tumors of smokers and patients who had never smoked. They found more non -synonymous mutations in tumors of smokers, but this difference was not in genes commonly found to be mutated in pancreatic cancer (K -ras , TP53, CDKN2A/p16, or SMAD4), but in less commonly mutated genes [118] .…”
Section: Smoking K -Ras Mutations and Pancreatic Adenocarcinomamentioning
confidence: 93%
“…Generell ist von einer Risikoerhöhung bei chronischer Pankreatitis, unabhängig ihrer Ätiologie, um den Faktor 1,4 bis 8,2 auszugehen. Dabei ist in den vorliegenden Studien die chronische Pankreatitis unscharf definiert, die Follow-up-Zeiträume sind unklar, und die Rolle der Confounding-Faktoren (Rauchen und Alkohol) ist nicht immer klar beschrieben [6,7].…”
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