Genetic nomenclature for loci controlling mouse lymphocyte antigens

Morse, Herbert C.; Shen, Francis X.; Hämmerling, Ulrich

doi:10.1007/bf00364270

Cited by 82 publications

(28 citation statements)

References 59 publications

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“…%' test). Unfortunately, there are no reference data for the expression of Ly and other non-H-2 alloantigens on ST spleen cells (17). so the identity of the alloantigens in addition to NK-3-1 detected by C3H anti-ST alloantisera is unknown.…”

Section: Discussionmentioning

confidence: 99%

Studies on natural killer (NK) cells IV NK‐3·1: A new NK cell specific alloantigen

et al. 1989

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Summary A new murine natural killer (NK) cell alloantigen, NK‐3·1, has been identified by analysis of the complement dependent anti‐NK cell activity of C3H anti‐ST and BALB/c anti‐DBA/2 alloantisera. Flow cytometric studies with a specific antiserum made in backcross mice indicate that this alloantigen is expressed by 2‐3% of the spleen cells of NZB and C57BL/6 mice, positive strains, but is undetectable on the spleen cells of C3H mice, a negative strain. Since NK‐1·1 and NK‐2·1 are also expressed on 2‐3% of spleen cells of positive strains we suggest that all three alloantigens identify the NK cells in normal mouse spleen which lyse the lymphoma target cell line YAC.

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Section: Discussionmentioning

confidence: 99%

Studies on natural killer (NK) cells IV NK‐3·1: A new NK cell specific alloantigen

et al. 1989

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“…Donor and competitor cells were distinguished using two alleles of Ly5 [36] -Ly5.1 and Ly5.2-that do not affect cell functions, but that are readily distinguished by flow cytometry [37]. From 3 donors of each genotype, 6 million BMC were intravenously transplanted with 6 million competitor BMC into each of 4 irradiated recipients per donor.…”

Section: Stage-specific Competitive Repopulation (Sscr)mentioning

confidence: 99%

Heterozygous Kit Mutants with Little or No Apparent Anemia Exhibit Large Defects in Overall Hematopoietic Stem Cell Function

Sharma

Astle

Harrison

2007

Experimental Hematology

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Objective-The evolutionarily conserved Kit receptor is vital for function of hematopoietic stem cells (HSC). Kit W-41 (W-41) and Kit W-42 (W-42) are single residue changes in the KIT intracellular phosphotransferase domain, while Kit W-v (W-v) is a single residue change in the ATP binding domain. This study tests how each mutation affects HSC function.Methods-Cells in mutant and C57BL/6J +/+ blood and marrow were compared. Overall HSC function was measured by competitive repopulation. Functions of specific progenitor populations were tested with stage-specific competitive repopulation and standard colony forming unit assays. Results-Bone marrow cells from these

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“…The repopulation efficiency of various hematopoietic lineages was determined by flow cytometry (n ϭ 4) using CD45 as a mouse strain marker (11). CD45 found in C57BL/6 mice is replaced by the alloantigen CD45.1 in B6.SJL-Ptprc a Pep3 b /BoyJ mice (12). Cells arising from different mouse strains can be distinguished using selective Abs and FACS.…”

Section: Effect Of Atl146e On Iri Of Liver In Wt and Chimeric Bmt Micementioning

confidence: 99%

A2A Adenosine Receptors on Bone Marrow-Derived Cells Protect Liver from Ischemia-Reperfusion Injury

Day

Rieger

et al. 2005

The Journal of Immunology

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Activation of the A2A adenosine receptor (A2AR) during reperfusion of various tissues has been found to markedly reduce ischemia-reperfusion injury. In this study, we used bone marrow transplantation (BMT) to create chimeric mice that either selectively lack or selectively express the A2AR on bone marrow-derived cells. Bolus i.p. injection of the selective A2A agonist, 4-{3-[6-amino-9-(5-cyclopropylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid methyl ester (ATL313; 3 μg/kg), at the time of reperfusion protects wild-type (wt) mice from liver ischemia-reperfusion injury. ATL313 also protects wt/wt (donor/recipient BMT mouse chimera) and wt/knockout chimera but produces modest protection of knockout/wt chimera as assessed by alanine aminotransferase activity, induction of cytokine transcripts (RANTES, IFN-γ-inducible protein-10, IL-1α, IL-1-β, IL-1Rα, IL-18, IL-6, and IFN-γ), or histological criteria. ATL313, which is highly selective for the A2AR, produces more liver protection of chimeric BMT mice than 4-{3-[6-amino-9-(5-ethylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-cyclohexanecarboxylic acid methyl ester, which is rapidly metabolized in mice to produce 4-{3-[6-amino-9-(5-ethylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-cyclohexanecarboxylic acid, which has similar affinity for the A2AR and the proinflammatory A3 adenosine receptor. GFP chimera mice were created to show that vascular endothelial cells in the injured liver do not account for liver protection because they are not derived by transdifferentiation of bone marrow precursors. The data suggest that activation of the A2AR on bone marrow-derived cells is primarily responsible for protecting the liver from reperfusion injury.

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Genetic nomenclature for loci controlling mouse lymphocyte antigens

Cited by 82 publications

References 59 publications

Studies on natural killer (NK) cells IV NK‐3·1: A new NK cell specific alloantigen

Studies on natural killer (NK) cells IV NK‐3·1: A new NK cell specific alloantigen

Heterozygous Kit Mutants with Little or No Apparent Anemia Exhibit Large Defects in Overall Hematopoietic Stem Cell Function

A2A Adenosine Receptors on Bone Marrow-Derived Cells Protect Liver from Ischemia-Reperfusion Injury

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