Genetic Organization, Tissue Expression, and Functional Role of Murine Ia Antigens

David, Chella S.; Beisel, Kirk W.; Krco, Christopher J.; Lafuse, William P.

doi:10.1007/978-1-4684-3758-4_4

Cited by 2 publications

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“…HLA-DR, DC/MB/MT/LB, or SB antigens) are essential for effective communication among cells participating in the immunological response (1). In humans and rodents, class II antigens are expressed most abundantly by B lymphocytes, activated T lymphocytes and antigen-presenting cells, such as cells ofthe monocyte/macrophage line, Langerhans cells ofthe skin, and dendritic cells of lymphoid organs (2,3). Thus, Ia-like antigens have been traditionally associated with immunologically active cells.…”

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confidence: 99%

Expression of Ia-like antigens by human vascular endothelial cells is inducible in vitro: demonstration by monoclonal antibody binding and immunoprecipitation.

Pober¹,

Gimbrone²

1982

Proc. Natl. Acad. Sci. U.S.A.

130

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The expression of Ia-like antigens by cultured human endothelial cells has been investigated by means of monoclonal antibody binding to intact cells and by immunoprecipitation of radioiodinated membrane proteins. Primary growing and confluent cultures of human umbilical vein endothelium express little, if any, detectable Ia-like antigens under standard culture conditions. However, treatment of primary cultures with the lectin phytohemagglutinin induces the expression of Ia-like antigens. This action of the lectin uniformly affects all the endothelial cells in a culture, does not depend on cell division, and is associated with a cell shape change. The data presented in this report provide unequivocal serological and biochemical demonstration of Ia-like antigens on human vascular endothelial cells. The fact that the expression of Ia-like antigens by endothelium can be induced may have important implications for organ transplantation and for regulation of the immunological response.

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confidence: 99%