Genetic pest management and the background genetics of release strains

Leftwich, Philip T.; Spurgin, Lewis G.; Harvey‐Samuel, Tim; Thomas, Callum J. E.; Paladino, Leonela Carabajal; Edgington, Matthew P.; Alphey, Luke

doi:10.1098/rstb.2019.0805

Cited by 28 publications

(19 citation statements)

References 95 publications

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“…The dependence of Satyrisation on incorrect mate choice could also create opportunities for synergies with other control methods, with the aim of inducing additive or even multiplicative effects (Leftwich et al 2016). Analysis and alteration of the genetic qualities of a target population and release strain, such as non-target loci, could be used to complement primary control strategies (Leftwich et al 2021). For example, one could ensure that any release strain intended to confer one primary mechanism of control, such as via Wolbachia infection, was also sensitive to Satyrisation.…”

Section: Satyrisation As a Control Methodsmentioning

confidence: 99%

Reproductive interference and Satyrisation: mechanisms, outcomes and potential use for insect control

et al. 2022

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Reproductive Interference occurs when interactions between individuals from different species disrupt reproductive processes, resulting in a fitness cost to one or both parties involved. It is typically observed between individuals of closely related species, often upon secondary contact. In both vertebrates and invertebrates, Reproductive Interference is frequently referred to as ‘Satyrisation’. It can manifest in various ways, ranging from blocking or reducing the efficacy of mating signals, through to negative effects of heterospecific copulations and the production of sterile or infertile hybrid offspring. The negative fitness effects of Satyrisation in reciprocal matings between species are often asymmetric and it is this aspect, which is most relevant to, and can offer utility in, pest management. In this review, we focus on Satyrisation and outline the mechanisms through which it can operate. We illustrate this by using test cases, and we consider the underlying reasons why the reproductive interactions that comprise Satyrisation occur. We synthesise the key factors affecting the expression of Satyrisation and explore how they have potential utility in developing new routes for the management and control of harmful insects. We consider how Satyrisation might interact with other control mechanisms, and conclude by outlining a framework for its use in control, highlighting some of the important next steps.

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Section: Satyrisation As a Control Methodsmentioning

confidence: 99%

Reproductive interference and Satyrisation: mechanisms, outcomes and potential use for insect control

et al. 2022

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“…One technical challenge, in particular, is introduced by Leftwich et al [36]. Releasing modified versions of an insect species is likely to result in mating occurring with wild species within the target area.…”

Section: Biotechnological Control Of Mosquitoesmentioning

confidence: 99%

Novel control strategies for mosquito-borne diseases

Jones

Ant

Cameron

et al. 2020

Phil. Trans. R. Soc. B

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Mosquito-borne diseases are an increasing global health challenge, threatening over 40% of the world's population. Despite major advances in malaria control since 2000, recent progress has stalled. Additionally, the risk of Aedes -borne arboviruses is rapidly growing, with the unprecedented spread of dengue and chikungunya viruses, outbreaks of yellow fever and the 2015 epidemic of Zika virus in Latin America. To counteract this growing problem, diverse and innovative mosquito control technologies are currently under development. Conceptually, these span an impressive spectrum of approaches, from invasive transgene cassettes with the potential to crash mosquito populations or reduce the vectorial capacity of a population, to low-cost alterations in housing design that restrict mosquito entry. This themed issue will present articles providing insight into the breadth of mosquito control research, while demonstrating the requirement for an interdisciplinary approach. The issue will highlight mosquito control technologies at varying stages of development and includes both opinion pieces and research articles with laboratory and field-based data on control strategy development. This article is part of the theme issue ‘Novel control strategies for mosquito-borne diseases'.

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“…However, it is known that the background genotype contributes significantly to the biological quality and the performance of insect strains aimed for releases especially in terms of mating success ( Quintero-Fong et al, 2016 ; Carvalho et al, 2020 ; Leftwich et al, 2021 ). Laboratory reared insects differ from wild ones due to combined effects of bottlenecking, high inbreeding, selection for artificial rearing, and genetic variation.…”

Section: Introductionmentioning

confidence: 99%

Genetic Stability and Fitness of Aedes aegypti Red-Eye Genetic Sexing Strains With Pakistani Genomic Background for Sterile Insect Technique Applications

Misbah-ul-Haq¹,

Carvalho²,

Fuente³

et al. 2022

Front. Bioeng. Biotechnol.

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The mosquito species Aedes aegypti is the primary transmitter of viruses that cause endemic diseases like dengue in Pakistan. It is also a cause of other vector-borne diseases like yellow fever, Zika fever, and chikungunya, which significantly impact human health worldwide. In the absence of efficient vaccines (except for yellow fever) or drugs, vector control methods, such as the sterile insect technique (SIT), have been proposed as additional tools for the management of these diseases. Mosquito SIT programs are based on the release of sterile males and it is important female releases to be ideally zero or to be kept at a minimum, since females are the ones that bite, blood-feed and transmit pathogens. Recently, an Ae. aegypti genetic sexing strain (GSS), with and without a recombination-suppressing inversion (Inv35), was developed using the eye color as a selectable marker, with males having black eyes and females red eyes. In the present study, we introgressed the sexing features and the Inv35 of the Ae. aegypti red-eye GSS into the Pakistani genomic background aiming to their future use for SIT applications in the country. Both introgressed strains, the Red-eye GSS-PAK and the Red-eye GSS/Inv35-PAK, were evaluated in respect to their genetic stability and biological quality by assessing parameters like recombination rate, fecundity, fertility, pupal and adult recovery, time of development, pupal weight, survival, and flight ability in comparison with a wild Pakistani population (PAK). The results suggest that the sexing features and the recombination suppression properties of Inv35 were not affected after their introgression into the local genomic background; however, some biological traits of the two newly constructed strains were affected, positively or negatively, suggesting that a thorough quality control analysis should be performed after the introgression of a GSS into a new genomic background prior to its use in SIT field trials or applications. The importance of using GSS with local genomic background for SIT applications against Aedes aegypti is also discussed.

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Genetic pest management and the background genetics of release strains

Cited by 28 publications

References 95 publications

Reproductive interference and Satyrisation: mechanisms, outcomes and potential use for insect control

Reproductive interference and Satyrisation: mechanisms, outcomes and potential use for insect control

Novel control strategies for mosquito-borne diseases

Genetic Stability and Fitness of Aedes aegypti Red-Eye Genetic Sexing Strains With Pakistani Genomic Background for Sterile Insect Technique Applications

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