2012
DOI: 10.1186/1475-2875-11-60
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Genetic polymorphism and natural selection of Duffy binding protein of Plasmodium vivax Myanmar isolates

Abstract: BackgroundPlasmodium vivax Duffy binding protein (PvDBP) plays an essential role in erythrocyte invasion and a potential asexual blood stage vaccine candidate antigen against P. vivax. The polymorphic nature of PvDBP, particularly amino terminal cysteine-rich region (PvDBPII), represents a major impediment to the successful design of a protective vaccine against vivax malaria. In this study, the genetic polymorphism and natural selection at PvDBPII among Myanmar P. vivax isolates were analysed.MethodsFifty-fou… Show more

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Cited by 30 publications
(38 citation statements)
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“…Analysis of genetic diversity of dbpII alleles among P. vivax isolates from different geographical regions, including Brazil, Colombia, South Korea and Papua New Guinea, shows that polymorphic residues are mostly concentrated in the ligand domain and vary by geographic region (1214). A study of dbp alleles in Papua New Guinea (PNG) found that the substitution rate within region II was 10 times greater than that found within the dbp gene overall (9) and that 93% of DBP polymorphisms were within the central segment of DBPII between cysteines 4 and 7 (9).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Analysis of genetic diversity of dbpII alleles among P. vivax isolates from different geographical regions, including Brazil, Colombia, South Korea and Papua New Guinea, shows that polymorphic residues are mostly concentrated in the ligand domain and vary by geographic region (1214). A study of dbp alleles in Papua New Guinea (PNG) found that the substitution rate within region II was 10 times greater than that found within the dbp gene overall (9) and that 93% of DBP polymorphisms were within the central segment of DBPII between cysteines 4 and 7 (9).…”
Section: Introductionmentioning
confidence: 99%
“…Analysis of field parasites shows that some polymorphic residues in DBPII are unique to one population or geographic region, while some variant amino acids, K371E, D384G, E385K, K386N, N417K, L424I, W347R and I503K are common among global vivax isolates (12, 13, 16, 17). However, only a few individuals produce anti-DBP responses that broadly inhibit against multiple allelic variants (18, 19).…”
Section: Introductionmentioning
confidence: 99%
“…Estos polimorfismos en posiciones análogas se han observado en organismos relacionados, incluido Plasmodium falciparum y Pneumocystis carinii, y se han asociado con resistencia a las sulfonamidas (13,31).…”
Section: Discussionunclassified
“…Despite the conserved nature of regions spanning the DARC-binding groove and dimer interface, many residues in DBPII are variable and these polymorphisms map to multiple non-functional regions of the protein (Tsuboi et al. 1994, Ampudia et al 1996, Xainli et al 2000, Kho et al 2001, VanBuskirk et al 2004b, Sousa et al 2006, Gosi et al 2008, Babaeekho et al 2009, Batchelor et al 2011, Premaratne et al 2011, Chenet et al 2012, Ju et al 2012, 2013). Some of these naturally-occurring polymorphisms flank critical residues and it is suggested that protective antibodies that target the functional regions in DBPII lead to disruption of dimerisation and/or prevention of receptor binding (Batchelor et al 2011).…”
mentioning
confidence: 99%
“…In addition, it was possible to demonstrate that natural selection acts differentially across the DBPII sequence, with neutrally evolving codons as well as codons evolving under diversifying selection (Cole-Tobian & King 2003, Martinez et al 2004, Sousa et al 2010). Of importance, positive natural selection preferentially acts on epitopes in DBPII, which also have greater nucleotide diversity (Cole-Tobian & King 2003, Sousa et al 2010, Ju et al 2012, 2013). This is in agreement with the hypothesis that immune selection is the major evolutionary force that drives the generation of new PvDBP variants.…”
mentioning
confidence: 99%