2022
DOI: 10.47162/rjme.63.2.03
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Genetic polymorphism and neuroanatomical changes in schizophrenia

Abstract: The article is a review of the latest meta-analyses regarding the genetic spectrum in schizophrenia, discussing the risks given by the disruptedin-schizophrenia 1 (DISC1), catechol-O-methyltransferase (COMT), monoamine oxidases-A/B (MAO-A/B), glutamic acid decarboxylase 67 (GAD67) and neuregulin 1 (NRG1) genes, and dysbindin-1 protein. The DISC1 polymorphism significantly increases the risk of schizophrenia, as well injuries from the prefrontal cortex that affect connectivity. NRG1 is one of the most important… Show more

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Cited by 5 publications
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“…Heredity plays an important role in the onset of mental disorders (4), and the heritability of schizophrenia has been estimated to be as high as 80% (5). Genetic information is expressed through genes, and single nucleotide polymorphisms (SNPS) are base-pair variations at speci c positions in the genome(6).…”
Section: Introductionmentioning
confidence: 99%
“…Heredity plays an important role in the onset of mental disorders (4), and the heritability of schizophrenia has been estimated to be as high as 80% (5). Genetic information is expressed through genes, and single nucleotide polymorphisms (SNPS) are base-pair variations at speci c positions in the genome(6).…”
Section: Introductionmentioning
confidence: 99%