2018
DOI: 10.1016/j.genrep.2018.06.019
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Genetic polymorphism in ADRB-1 is associated with type 2 diabetes susceptibility in Iranian population

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Cited by 15 publications
(5 citation statements)
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“…Polymorphisms in the three subtypes of β-adrenoceptor (ADRB1, ADRB2, and ADRB3 genes) show a correlation with obesity and body weight-related disorders [66]. ADRB1 also contributes to increased secretion of renin and ghrelin hormones, which are associated with T2D and insulin resistance [67]. Studies suggest that p.Arg389Gly polymorphism in the ADRB1 may be a potential genetic biomarker to assess the risk of developing cardiovascular diseases [68].…”
Section: Discussionmentioning
confidence: 99%
“…Polymorphisms in the three subtypes of β-adrenoceptor (ADRB1, ADRB2, and ADRB3 genes) show a correlation with obesity and body weight-related disorders [66]. ADRB1 also contributes to increased secretion of renin and ghrelin hormones, which are associated with T2D and insulin resistance [67]. Studies suggest that p.Arg389Gly polymorphism in the ADRB1 may be a potential genetic biomarker to assess the risk of developing cardiovascular diseases [68].…”
Section: Discussionmentioning
confidence: 99%
“…As disease susceptibility can't be attributed to a single polymorphism or allele, but rather to a combination of multiple polymorphisms [41][42][43][44]. We evaluated gene-gene interactions using multifactor dimension reduction (MDR), a novel method to examine the combined effects of multiple factors in disease susceptibility [45].…”
Section: Plos Onementioning
confidence: 99%
“… 15 Other gene polymorphisms have also been recognized as predisposing risk factors and therapeutic targets for DM with or without kidney diseases. These include sirtuin 1 ( SIRT1 ) rs12778366 and rs3758391, 16 β1‐Adrenegic receptor ( ADRB‐1 ) rs1801253C/G, 17 NR1H2 gene encoding LXRβ (28,514,894 and rs2303044), 18 miR143/145 cluster, 19 and miR29a (rs157907A/G). 20 …”
Section: Introductionmentioning
confidence: 99%