Genetic Polymorphism in Cytokines and Costimulatory Molecules in Stem Cell and Solid Organ Transplantation

Jindra, Peter T.; Cusick, Matthew F.

doi:10.1016/j.cll.2018.10.002

Cited by 3 publications

(1 citation statement)

References 87 publications

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“…Most solid organ transplant genetic studies used individuals of European descent (Table 1), [63][64][65] and thus the applicability of their findings to a more diverse patient population remains to be determined. One source of variation that strengthens differences in transplant outcomes between population groups are unique, non-HLA population-specific variants from ethnically diverse donor-recipient pairings.…”

Section: Current Limitations For Gwas In Transplantation: Reproducibi...mentioning

confidence: 99%

The Impact of Donor and Recipient Genetic Variation on Outcomes After Solid Organ Transplantation: A Scoping Review and Future Perspectives

Nieuwenhuis

Keating

et al. 2021

Transplantation

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Section: Current Limitations For Gwas In Transplantation: Reproducibi...mentioning

confidence: 99%

The Impact of Donor and Recipient Genetic Variation on Outcomes After Solid Organ Transplantation: A Scoping Review and Future Perspectives

Nieuwenhuis

Keating

et al. 2021

Transplantation

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Genetically modified immunomodulatory cell-based biomaterials in tissue regeneration and engineering

Jiang

Zhu

et al. 2022

Cytokine & Growth Factor Reviews

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Cytokine gene polymorphism frequencies in Turkish population living in Marmara region

Özdilli

Öğret

Oğuz

et al. 2022

Turkish Journal of Biochemistry

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Objectives Sequence variants in cytokine genes are related to affect cytokine gene levels. In this study, it was aimed to examine eight single nucleotide polymorphisms (SNPs) in five cytokine genes (TNF-α, INF-γ, IL-6, IL10, TGF-β) for the Turkish population living in Marmara region and to reveal the genetic distance between the study group and other populations. Methods In this study, three-hundred unrelated healthy individuals were involved and all genotyping were performed by using sequence-specific primers PCR (PCR-SSP) method. The SNP data were analyzed for Hardy Weinberg equilibrium fit by calculating expected genotype frequencies and comparing them to the observed values using Arlequin software version 3.1. The genetic distances between the study group and other populations were calculated and a neighbor-joining tree was constructed by PHYLIP. Results The observed genotypes of TNF-α (−308), IFN-γ (+874), TGF-β (codon 10), and TGF-β (codon 25) of the subjects were found to be similar with other populations investigated in this study. However, there is a significant frequency difference for IL-6 and IL-10 genotypes between populations. Conclusions The current population study provided more reference values for these polymorphisms and generated a control group to be used in further association studies especially for transplantation, GVHD, autoimmune and malign disease.

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Genetic Polymorphism in Cytokines and Costimulatory Molecules in Stem Cell and Solid Organ Transplantation

Cited by 3 publications

References 87 publications

The Impact of Donor and Recipient Genetic Variation on Outcomes After Solid Organ Transplantation: A Scoping Review and Future Perspectives

The Impact of Donor and Recipient Genetic Variation on Outcomes After Solid Organ Transplantation: A Scoping Review and Future Perspectives

Genetically modified immunomodulatory cell-based biomaterials in tissue regeneration and engineering

Cytokine gene polymorphism frequencies in Turkish population living in Marmara region

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