2009
DOI: 10.1038/tpj.2009.31
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Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese

Abstract: The cytochrome P450 2C19 and 2D6 enzymes are predominantly found in the human liver, and have important functions in the metabolism of many different classes of commonly used drugs. Their genetic polymorphisms give rise to both important interethnic variability in metabolism and the risk of treatment failure or dose-dependent drug toxicity. To investigate genetic polymorphisms in CYP2C19 and CYP2D6 genes in Han Chinese, we sequenced regions of the 5 0 flanking region, exon, intron and 3 0 UTR from these two ge… Show more

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Cited by 56 publications
(41 citation statements)
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“…For instance, the frequencies of the loss-of-function genotypes (e.g., in *2 and *3 in CYP2C19) are higher in Asians than Caucasians or Africans (Luo et al, 2006;Mizutani, 2003). In the current study cohort, the frequencies of CYP2C19*2 and *3 were 31.5% and 4.2%, respectively, which were consistent with the report in a previous study in a Han Chinese population (Zhou et al, 2009). The allele frequencies of CYP2C19*17 in Asians were approximately 0.5% (Tsai et al, 2010) to 0.64% (Wang et al, 2009), which were too low to be calculated in our ethnic group.…”
Section: Discussionsupporting
confidence: 91%
“…For instance, the frequencies of the loss-of-function genotypes (e.g., in *2 and *3 in CYP2C19) are higher in Asians than Caucasians or Africans (Luo et al, 2006;Mizutani, 2003). In the current study cohort, the frequencies of CYP2C19*2 and *3 were 31.5% and 4.2%, respectively, which were consistent with the report in a previous study in a Han Chinese population (Zhou et al, 2009). The allele frequencies of CYP2C19*17 in Asians were approximately 0.5% (Tsai et al, 2010) to 0.64% (Wang et al, 2009), which were too low to be calculated in our ethnic group.…”
Section: Discussionsupporting
confidence: 91%
“…However, this study also was conducted in small number of subjects (5, 5, and 4 subjects with CYP2D6*wt/*wt, CYP2D6*wt/*10, and CYP2D6*10/ *10 genotypes, respectively). Based on our unpublished data, the frequencies of the CYP2D6*wt/*wt, *wt/*10 and *10/*10 genotypes are about 24.7, 43.3 and 25.0 % in the Korean population, respectively, and similar frequencies have been reported in Chinese and Japanese populations (Nishida et al 2000;Ji et al 2002;Zhou et al 2009;Lee et al 2009). Thus, to evaluate the impact of the CYP2D6*10 allele on the pharmacokinetics of atomoxetine, dividing subjects into Fig.…”
Section: Discussionsupporting
confidence: 71%
“…Steady-state mean plasma concentration-time profile according to genotypes for SNP rs4918758 after administration of the last dose of indapamide 1.5 mg at 216 h. HOMO homozygous, HET heterozygous, WT wild type, n sample size. Data are mean±SD at specific times of Taiwanese or Chinese, the largest races in Asia (23)(24)(25)(26)(27). The current study provides an extensive survey of the genetic variances among eight selected major DMEs in Taiwanese, which is considered the closest population to Han Chinese.…”
Section: Discussionmentioning
confidence: 99%