Genetic Polymorphism of 27 Y-STR Loci in the Western Kazakh Tribes from Kazakhstan and Karakalpakstan, Uzbekistan

Ashirbekov, Yeldar; Sabitov, Zhaxylyk; Aidarov, Baglan; Abaildayev, Arman; Junissova, Zukhra; Cherusheva, Alena; Saidamarova, Viktoriya V.; Sharipov, Kamalidin; Ramankulov, Yerlan; Zhabagin, Maxat

doi:10.3390/genes13101826

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Forensic parameters were calculated that characterize the population of Kazakhs in the southern region of Kazakhstan: Discrimination Capacity (DC = 91.23%), Haplotype match probability (HPM = 0.0029) and haplotype diversity (HD = 0.9992) (Table 1 ). The indicators are comparable with the results for the general mixed samples of Kazakhs in Kazakhstan [ 22 ] and rank second in diversity after the population of Kazakhs from Karakalpakstan [ 24 ].…”

Section: Resultssupporting

confidence: 79%

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Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan

Ashirbekov,

Seidualy,

Abaildayev

et al. 2023

BMC Genomics

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Background The Kazakhs are one of the biggest Turkic-speaking ethnic groups, controlling vast swaths of land from the Altai to the Caspian Sea. In terms of area, Kazakhstan is ranked ninth in the world. Northern, Eastern, and Western Kazakhstan have already been studied in relation to genetic polymorphism 27 Y-STR. However, current information on the genetic polymorphism of the Y-chromosome of Southern Kazakhstan is limited only by 17 Y-STR and no geographical study of other regions has been studied at this variation. Results The Kazakhstan Y-chromosome Haplotype Reference Database was expanded with 468 Kazakh males from the Zhambyl and Turkestan regions of South Kazakhstan by having their 27 Y-STR loci and 23 Y-SNP markers analyzed. Discrimination capacity (DC = 91.23%), haplotype match probability (HPM = 0.0029) and haplotype diversity (HD = 0.9992) are defined. Most of this Y-chromosome variability is attributed to haplogroups C2a1a1b1-F1756 (2.1%), C2a1a2-M48 (7.3%), C2a1a3-F1918 (33.3%) and C2b1a1a1a-M407 (6%). Median-joining network analysis was applied to understand the relationship between the haplotypes of the three regions. In three genetic layer can be described the position of the populations of the Southern region of Kazakhstan—the geographic Kazakh populations of Kazakhstan, the Kazakh tribal groups, and the people of bordering Asia. Conclusion The Kazakhstan Y-chromosome Haplotype Reference Database was formed for 27 Y-STR loci with a total sample of 1796 samples of Kazakhs from 16 regions of Kazakhstan. The variability of the Y-chromosome of the Kazakhs in a geographical context can be divided into four main clusters—south, north, east, west. At the same time, in the genetic space of tribal groups, the population of southern Kazakhs clusters with tribes from the same region, and genetic proximity is determined with the populations of the Hazaras of Afghanistan and the Mongols of China.

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Section: Resultssupporting

confidence: 79%

“…The indicators are comparable with the results for the general mixed samples of Kazakhs in Kazakhstan [ 22 ] and rank second in diversity after the population of Kazakhs from Karakalpakstan [ 24 ].…”

Section: Resultssupporting

confidence: 79%

Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan

Ashirbekov,

Seidualy,

Abaildayev

et al. 2023

BMC Genomics

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“…Affiliation of haplotypes to haplogroups was assessed using Nevgen Y-DNA haplogroup predictor ( https://www.nevgen.org/ ) and by comparing haplotypes from published data. The analysis incorporated an extensive dataset, which included 3306 haplotypes for minimum 17 Y-STRs from existing studies on population samples of Kazakhs [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] . In the search for similar haplotypes, the study employed the Haplomatch tool [18] to analyze Y-chromosome STR haplotypes.…”

Section: Discussionmentioning

confidence: 99%

Population dataset for 23 Y-STR in the Merkit clan form Kazakh population

Faizov,

Bukayev,

Sabitov

et al. 2024

Data in Brief

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“…The Y chromosome has a segment that does not undergo recombination with the X chromosome during meiosis, and approximately 95% of the regions that cannot be exchanged or recombined are known as the non-recombining region of the Y chromosome (NRY) [ 2 ]. The main methods that analyze genetic diversity are the analysis of short tandem repeat polymorphism on the Y chromosome (Y-STR) and single nucleotide polymorphisms on the Y chromosome (Y-SNP) [ 3 ]. Y-SNPs are characterized by slow mutations, with the potential to be used in forensics, ancestral inference studies, and the investigation of human evolution [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Diversity Based on Human Y Chromosome Analysis: A Bibliometric Review Between 2014 and 2023

Hodișan,

Zaha,

Jurca

et al. 2024

Cureus

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The Y chromosome has gained significant importance in the examination of genetic studies of populations because of its non-recombinant character and its form of uniparental inheritance. This work seeks to offer a comprehensive review of the specialty literature in the field of population genetics, focusing specifically on the analysis of the human Y chromosome using a bibliometric approach and knowledge mapping. This involves establishing worldwide structural networks by identifying the primary research themes, authors, and papers that have had a significant impact on the academic community. The objective is to examine global publications by analyzing citations at both the document and country level. This will involve conducting co-citation analysis for references with a high number of citations, examining bibliographic coupling through journal analysis, analyzing the co-occurrence of keywords, and investigating collaboration between authors from a country perspective. The research papers have been extracted from the Web of Science database. The bibliometric analysis was performed using the Bibliometrix and VOSviewer software tools. The purpose of this article is to serve as a starting point for future research dedicated to the analysis of the diversity of human Y chromosome haplotypes. The objectives of the study were to identify and present the most cited publications and references with the highest number of citations, and to highlight current publications at the national level.

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Genetic Polymorphism of 27 Y-STR Loci in the Western Kazakh Tribes from Kazakhstan and Karakalpakstan, Uzbekistan

Cited by 6 publications

References 21 publications

Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan

Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan

Population dataset for 23 Y-STR in the Merkit clan form Kazakh population

Genetic Diversity Based on Human Y Chromosome Analysis: A Bibliometric Review Between 2014 and 2023

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