Genetic Polymorphism of Aldehyde Dehydrogenase 2 in Patients With Upper Aerodigestive Tract Cancer

Tanabe, Hiroki; Ohhira, Masumi; Ohtsubo, Tikara; Watari, Jiro; Yokota, Kinichi; Kohgo, Yutaka

doi:10.1111/j.1530-0277.1999.tb04527.x

Cited by 31 publications

(22 citation statements)

References 22 publications

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“…But, this does not deny the possibility that smoking is a risk factor for solitary esophageal cancer. Another reason for the fact that alcohol but not cigarette smoking turns comeout to be risk factor for esophageal cancer is discussed in our previous reports (12). Briefly, patients with HNC, esophageal cancer, and concomitant cancer were compared for risk factors and genetic polymorphisms of alcohol metabolic enzymes.As a result, acetaldehyde, whichis the product metabolised from alcohol, is proposed to contribute in carcinogenesis of esophageal cancer.…”

Section: Discussionmentioning

confidence: 99%

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Alcohol Consumption as a Major Risk Factor in the Development of Early Esophageal Cancer in Patients with Head and Neck Cancer.

et al. 2001

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Objective To clarify the incidence of concomitant esophageal cancers in patients with head and neck cancer (HNC), and to investigate which risk factors are responsible for this association.Patients and Methods From 1994 to 2000, 134 patients with HNCunderwent upper gastrointestinal endoscopy using the 0.8% Lugol stain method to detect esophageal cancer. Acase-control study was designed to compare HNC patients with and without esophageal cancer. Logistic-regression analysis was used to obtain odds ratios of risk factors.Results Out of 134 patients with HNC, Lugol unstained area was detected in 42 patients. Biopsy specimens revealed squamous cell carcinoma in 17 (12.7%), dysplasia in 9 patients (6.6%), and normal in the others. Gastric carcinoma was also detected in 7 patients (5.2 %). The estimated depth of cancer invasion was mucosa in 9 patients, submucosa in 5 patients, and proper muscle or deeper in 3 patients. In the results of statistical analysis, high alcohol consumption of more than 75 g per day increased the risk of esophageal cancer (odds ratio: 20.2, p<0.01). Intake of hard liquor showed a high odds ratio (whisky: 28.7, p<0.05, shochu: 12.7, p<0.05). The amount of cigarette smoking was not related to this association. Conclusion High incidence of esophageal cancer was found in the patients with HNC. A high alcohol consumption level, and in particular hard liquor, participated in the development of esophageal cancer in the patients with HNC. But cigarette smoking was not related to this association. (Internal Medicine 40: 692-696, 2001)

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Section: Discussionmentioning

confidence: 99%

“…This association seemsto be reasonable because these cancers share commonrisk factors. But there are few reports that mention the risks in these patients (12). In this context, it is important to determine which factors are responsible for the development of concomitant esophageal cancer.…”

Section: Introductionmentioning

confidence: 99%

Alcohol Consumption as a Major Risk Factor in the Development of Early Esophageal Cancer in Patients with Head and Neck Cancer.

et al. 2001

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“…This fact is supported by growing evidence that deficiencies and polymorphisms of various ALDH enzymes can lead to clinical phenotypes and diseases [5,8,11]. Some examples of these metabolic syndromes and diseases include spina bifida (ALDH1A2) [93], ethanol-induced cancers [94] and hypertension (ALDH2) [95], Sjögren-Larsson syndrome (ALDH3A2) [96], type II hyperprolinemia (ALDH4A1) [97], , γ-hydroxybutyric aciduria (ALDH5A1) [98], and pyridoxine-dependent epilepsy (ALDH7A1) [99] (reviewed in detail in [5,8,11]). ALDH1A1 and ALDH3A1 can also offer cellular protection against cytotoxic drugs.…”

Section: Aldh Plays a Self-protective Role In Normal Stem Cells And Cscsmentioning

confidence: 98%

The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells

Allan

2010

Stem Cell Rev and Rep

462

412

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Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have the capacity to self-renew and differentiate into multiple cell types. In both the normal stem cell and cancer stem cell fields, there has been a great need for a universal marker that can effectively identify and isolate these rare populations of cells in order to characterize them and use this information for research and therapeutic purposes. Currently, it would appear that certain isoenzymes of the aldehyde dehydrogenase (ALDH) superfamily may be able to fulfill this role as a marker for both normal and cancer stem cells. ALDH has been identified as an important enzyme in the protection of normal hematopoietic stem cells, and is now also widely used as a marker to identify and isolate various types of normal stem cells and CSCs. In addition, emerging evidence suggests that ALDH1 is not only a marker for stem cells, but may also play important functional roles related to self-protection, differentiation, and expansion. This comprehensive review discusses the role that ALDH plays in normal stem cells and CSCs, with focus on ALDH1 and ALDH3A1. Discrepancies in the functional themes between cell types and future perspectives for therapeutic applications will also be discussed.

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“…Many epidemiological studies have shown that the risk of ethanol-associated digestive tract cancers is greatly increased in Asian subjects with genetically de cient ability to metabolize acetaldehyde (14)(15)(16)(17)(18)(19)(20). Recent studies have shown that these individuals with mutated aldehyde dehydrogenase-2 (ALDH2) enzyme have two to three times higher in vivo salivary acetaldehyde levels after a moderate dose of alcohol than those with a normal ALDH2 enzyme (21,22).…”

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Ethanol-derived Microbial Production of Carcinogenic Acetaldehyde in Achlorhydric Atrophic Gastritis

Väkeväinen¹,

Mentula²,

Nuutinen³

et al. 2002

Scandinavian Journal of Gastroenterology

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Genetic Polymorphism of Aldehyde Dehydrogenase 2 in Patients With Upper Aerodigestive Tract Cancer

Abstract: These results demonstrated the difference in the frequency of ALDH2 heterozygote between the patients with esophageal cancer and patients with head and neck cancer.

Cited by 31 publications

References 22 publications

Alcohol Consumption as a Major Risk Factor in the Development of Early Esophageal Cancer in Patients with Head and Neck Cancer.

Alcohol Consumption as a Major Risk Factor in the Development of Early Esophageal Cancer in Patients with Head and Neck Cancer.

The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells

Ethanol-derived Microbial Production of Carcinogenic Acetaldehyde in Achlorhydric Atrophic Gastritis

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