Genetic Polymorphism of CYP2A6 and Its Relationship with Nicotine Metabolism in Male Bataknese Smokers Suffered from Lung Cancer in Indonesia

Soeroso, Noni Novisari; Zain-Hamid, Rozaimah; Sinaga, Bintang Yinke Magdalena; Sadewa, Ahmad Hamim; Syafiuddin, Tamsil; Syahruddin, Elisna; Tann, Gino; Mutiara, Erna

doi:10.3889/oamjms.2018.259

Cited by 17 publications

(17 citation statements)

References 30 publications

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“…The histopathology image characteristic showed 87.5% of adenocarcinoma case. This is also the same as a result shown in Soeroso et al study in 2018 that found 92.9% of adenocarcinoma type cases [10], [11].…”

Section: Discussionsupporting

confidence: 90%

The Characteristic of Secondary Lung Tumours in Medan

Soeroso¹,

Afiani²,

Tarigan³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND:Metastatic malignant neoplasms are the most commonly known as secondary lung tumour. Any cancer could have the ability to spread to the lung. The secondary tumour most typically appears on radiologic findings are multiple nodules pleural effusion, etc.AIM:To observe the characteristic of secondary lung tumours patients in Haji Adam Malik General Hospital.MATERIAL AND METHODS:Research design is a cross-sectional with consecutive sampling to 53 patients that are diagnosed with secondary lung tumours. The data was taken from the medical record of secondary lung tumours diagnoses in Haji Adam Malik General Hospital medical record department.RESULTS:From the study, most cases are found in < 40-year-old age group with a percentage of 34%. The highest secondary lung tumour was ovarian carcinoma (13.2%) and multiple nodules (52.8%) from radiology images. Adenocarcinoma is the most found cytology/histopathology type which is around 69.8%.CONCLUSION:Female ages < 40 years are the group with the most cases of secondary lung tumours. Primary tumour from the ovarian is the main cause of secondary lung tumour.

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Section: Discussionsupporting

confidence: 90%

The Characteristic of Secondary Lung Tumours in Medan

Soeroso¹,

Afiani²,

Tarigan³

et al. 2019

Open Access Maced J Med Sci

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“…This study found that the most common type of lung cancer found in Batak tribe in Indonesia was adenocarcinoma (92.9%), and the most consumed cigarette type was clove cigarettes. Clove cigarettes contain clove that will make smokers suck in more deeply; thus, smokes containing carcinogenic substances eventually enter the peripheral respiratory tract [ 16 ], [ 18 ]. Syahruddin et al, [ 19 ] found that the EGFR mutations rate among Indonesian population reached 57.1% common mutations (exon 19 ins/dels, L858r) and about 29% uncommon mutations (G719X, exon 20 ins, T790M, L861Q).…”

Section: Discussionmentioning

confidence: 99%

Procalcitonin Level in Non-Small Cell Lung Cancer Patients among Indonesian Population

Soeroso¹,

Tanjung²,

Afiani³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Serum Procalcitonin (PCT) is a biomarker that is frequently used to diagnose an infection. In some cases of thoracic malignancy, procalcitonin level appears to increase. However, the role of procalcitonin to diagnose malignancy is not certain yet, and the causes have not been known.AIM:This study aimed to investigate procalcitonin levels in non-small cell lung cancer patients.METHODS:This was an observational study with a cross-sectional design. All lung cancer patients did not diagnose based on cytology/histopathology results with no evidence nor were signs and symptoms of infection recruited through consecutive sampling. The subtypes of lung cancer include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma, staged III and IV. The procalcitonin levels were analysed from blood using immunofluorescent assay. Data were then analysed with the Chi-Square test by Epi Info™ 7 programs in which p-value < 0.05 was considered statistically significant.RESULTS:A total of 68 lung cancer patients fulfilled the criteria of this study, 55 men (80.9%) and 13 women (19.1%). The highest percentage of cytology/histopathology type found was adenocarcinoma (80.9%), and 60.3% of those were diagnosed in stage IV. An increased procalcitonin level (greater than 0.01 ng/mL) occurred in 80.9% of Non-Small Cell Lung Cancer (NSCLC) patients. It appears that the higher the stage of lung cancer, the lower procalcitonin levels would be, although it was not statistically significant. There was no association between lung cancer subtype with procalcitonin levels.CONCLUSION:An increased level of procalcitonin may be an indication not only for infection but also for Non-Small Cell Lung Cancer.

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“…Meanwhile, it has been recognized that differences in the activity of enzymes involved in nicotine metabolism are partly responsible for inter-individual variation in lung cancer risk among smokers [32,33,34,35]. CYP2A6 is a principal enzyme in nicotine metabolism, and CYP2A6-mediated C-oxidase activity has been reported to correlate with exposure to carcinogens by smoking [32,33,34,35]. Many reports have demonstrated that CYP2A6 variants that exert reduced enzymatic activity are associated with lower lung cancer risk [32,33,34,35].…”

Section: Discussionmentioning

confidence: 99%

“…CYP2A6 is a principal enzyme in nicotine metabolism, and CYP2A6-mediated C-oxidase activity has been reported to correlate with exposure to carcinogens by smoking [32,33,34,35]. Many reports have demonstrated that CYP2A6 variants that exert reduced enzymatic activity are associated with lower lung cancer risk [32,33,34,35]. However, these genetic polymorphisms are reported to account for only a portion of the variation in CYP2A6 activity [4].…”

Section: Discussionmentioning

confidence: 99%

Determination of Urinary Caffeine Metabolites as Biomarkers for Drug Metabolic Enzyme Activities

et al. 2019

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Caffeine is commonly taken via the daily dietary consumption of caffeine-containing foods. The absorbed caffeine is metabolized to yield various metabolites by drug-metabolizing enzymes, and measuring the levels of each caffeine metabolite can provide useful information for evaluating the phenotypes of those enzymes. In this study, the urinary concentrations of caffeine and its 13 metabolites were determined, and the phenotypes of drug metabolic enzymes were investigated based on the caffeine metabolite ratios. Human urine samples were pretreated using solid phase extraction, and caffeine and its metabolites were analyzed using liquid chromatography-tandem mass spectrometry. Based on the urinary caffeine metabolite concentrations, the caffeine metabolite ratios were calculated for six human subjects at specified time points after caffeine intake. Variations in urinary metabolite levels among individuals and time points were reported. In addition, the resultant enzyme activities showed different patterns, depending on the metabolite ratio equations applied. However, some data presented a constant metabolite ratio range, irrespective of time points, even at pre-dose. This suggests the possibility of urinary caffeine metabolite analysis for routine clinical examination. These findings show that urinary caffeine and the metabolite analysis would be useful in evaluating metabolic phenotypes for personalized medicine.

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Genetic Polymorphism of CYP2A6 and Its Relationship with Nicotine Metabolism in Male Bataknese Smokers Suffered from Lung Cancer in Indonesia

Cited by 17 publications

References 30 publications

The Characteristic of Secondary Lung Tumours in Medan

The Characteristic of Secondary Lung Tumours in Medan

Procalcitonin Level in Non-Small Cell Lung Cancer Patients among Indonesian Population

Determination of Urinary Caffeine Metabolites as Biomarkers for Drug Metabolic Enzyme Activities

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