Genetic Polymorphism of Glutathione S-transferase and Cervical Cancer Susceptibility in Northeastern Thailand

Settheetham-Ishida, Wannapa; Wongpratate, Mayuree; Phuthong, Sophida; Natphopsuk, Sitakan; Ishida, Takafumi

doi:10.31557/apjcb.2020.5.2.35-41

Cited by 8 publications

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“…Ma Ning [25] genotype data were incomplete, and the literature was excluded. Baseline characteristics and quality scores of references [20–53] are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of XRCC1 single nucleotide polymorphism and susceptibility to gynecological malignancies

Zhang

2021

Medicine

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Background: Gynecological malignant tumor is a serious threat to women's health, cervical cancer, endometrial cancer and ovarian cancer are the most common. The eponymous protein encoded by the XRCC1 (X-ray repair cross complementation 1) gene is an important functional protein in the process of single-stranded DNA damage. Non-synonymous mutations of XRCC1 gene cause amino acid sequence changes that affect protein function and DNA repair ability, and may affect the interaction with other DNA repair proteins, leading to increased risk of tumor development. Many studies have assessed the association between XRCC1 gene polymorphism and the risk of cancer in the female reproductive system, but the results have been inconclusive. In this study, the relationship between XRCC1 Arg399Gln, Arg194Trp, Arg280His single nucleotide polymorphisms and susceptibility to gynecological malignancies was further explored by meta-analysis. Methods: English database: Pubmed, Medline, Excerpta Medica Database, Cochrance, etc; Chinese database: China national knowledge infrastructure, Wanfang Database, etc. STATA14 was used for statistical analysis, such as odd ratio (OR) value, subgroup analysis, heterogeneity test, sensitivity analysis, and publication bias. Results: In gynecologic cancers, the allele frequency difference of Arg399Gln case control group was statistically significant (GvsA: P = .007). There was no significant difference in allele frequency in the Arg194Trp and Arg280His case control groups ( P = .065, 0.198). In different gene models, Arg399Gln was significantly correlated with gynecologic cancers susceptibility (GGvs AA: OR 0.91; 95% confidence interval [CI], 0.85 0.98); Arg194Trp was significantly correlated with gynecologic cancers susceptibility (CCvs TT: OR 0.94; 95% CI 0.88,1.00; CCvs CT: OR 0.97; 95% CI 0.90, 1.05); Arg280His was significantly correlated with gynecologic cancers susceptibility (GGvs AA: OR 0.98; 95% CI 0.94, 1.02; GGvs GA: OR 1.00;95% CI 0.97, 1.04). In the subgroup analysis, Arg399Gln and Arg194Trp were significantly correlated with gynecologic cancers susceptibility in the Asian race ( P = .000, 0.049). In the analysis of different cancer subgroups, Arg399Gln and cervical cancer susceptibility were statistically significant ( P = .039). Arg194Trp and endometrial cancer susceptibility were statistically significant ( P = .033, 0.001). Conclusions: XRCC1 Arg399Gln, Arg194Trp, Arg280His single nucleotide polymorphisms were associated with gynecologic cancer susceptibility. Arg399Gln genotype was statistically significant in relation to cervical cancer susceptibility. Arg194Trp genotype was statistically significant in relation to endometrial cancer susceptibility.

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“…Ma Ning [25] genotype data were incomplete, and the literature was excluded. Baseline characteristics and quality scores of references [20–53] are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of XRCC1 single nucleotide polymorphism and susceptibility to gynecological malignancies

Zhang

2021

Medicine

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“…The frequencies of genotype and allele of GSTA1 -69C>T polymorphism have been reported in diverse populations. The findings obtained for the Turkish population were compared with the results reported for various populations [4,6,8,9,[12][13][14][15][16][17][18][19][20][21][22][23][24][25] as depicted in Table 2. Accordingly, GSTA1 -69T variant allele was more frequent in South Tunisians and Germans compared to other populations.…”

Section: Discussionmentioning

confidence: 99%

Frequencies of glutathione S-transferase A1 rs3957357 polymorphism in a Turkish population

Şahinoğulları¹

2021

Journal of Surgery and Medicine

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Background/Aim: Glutathione-S-transferases (GSTs), a major group of phase II enzymes, play a significant role in the detoxification and metabolism of endogenous and exogenous compounds. The objective of the survey was to identify the distribution of genotype and allele frequencies of GSTA1 -69C>T (rs3957357) polymorphism in a healthy Turkish population and compare the determined frequencies with those in various populations. Methods: Polymerase chain reaction and restriction fragment length polymorphism methods were used to analyze GSTA1 -69C>T polymorphism in DNA samples of 105 healthy Turkish individuals. Results: The distribution of GSTA1 CC, CT, and TT genotype frequencies were 32.4%, 48.6% and 19.0%, respectively while the allele frequencies were 56.7% for C allele and 43.3% for T allele. The findings obtained were compared with the results of various populations. The frequencies of GSTA1 -69C>T polymorphism were similar to those of the African American population and the populations with White ancestry, but significantly different from those reported for the populations with Asian ancestry. Conclusion:To the best of our knowledge, this is the first study to present the frequencies of the GSTA1 -69C>T polymorphism among Turkish individuals. The findings of the current study may provide a perspective for further studies exploring the role of GSTA1 -69C>T polymorphism on predisposition to diverse illnesses such as cancer and may be used as a control group for such studies. In addition, this study might contribute to epidemiological and toxicogenetic investigations.

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“…Moreover, polymorphism in the glutathione Stransferase (GST) gene was reported, with the null genotype of GSTT1 resulting in a 3-and 4-fold increased risk of cervical cancer among cervical cancer patients who had a smoking partner and who used oral contraceptives, respectively. Furthemore, the heterozygous and null genotypes of GSTM1 were associated with a 2.6-and 1.7-fold increased risk of cervical cancer when compared with the respective wild-type (present) genotype [38]. Similarly, a meta-analysis reported that the null genotype of GSTM1 was associated with an increased risk of cervical cancer, particularly in the Indian and Chinese populations [39].…”

Section: Risk Factors Of Cervical Cancermentioning

confidence: 97%

“…In terms of the causes and necessary risk factors for cervical cancer in Thailand, HPV infection, especially type 16 and 18, remains the main cause of cervical cancer among Thai women, as in other countries [15][16][17][18]. Moreover, many studies have reported an association between risk factors and an increased risk of cervical cancer in Thai women, including exposure to, certain risk factors and genetic polymorphisms, such as VDR, CYP1A1, MDR, and GST [17,[31][32][33][34][35][36][37][38][39][40][41]. Finally, the COVID-19 pandemic resulted in an interruption to cervical cancer screening globally [55][56][57][58]68].…”

Section: Mayuree Wongpratate Et Al Cervical Cancer In Thailandmentioning

confidence: 99%

Cervical cancer in Thailand: 2023 update

Wongpratate,

Bumrungthai

2024

Obstet Gynecol Sci

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Cervical cancer continues to pose a challenge to the health of Thai women, as the second most common cancer after breast cancer. Since high-risk human papillomavirus (HPV) types are the main cause for cervical cancer, cervical cancer screening and HPV vaccination are necessary to reduce the incidence of this disease. At present, the World Health Organization hopes to reduce the incidence of cervical cancer to 4 or less cases per 100,000 women-years using 90%- 70%-90% intervention by 2030. The first intervention involves vaccinating 90% of women aged 15 years with the HPV vaccine. The second intervention involves screening 70% of women between the ages of 35 and 45 years using a high-performance screening test. The third intervention involves detecting cervical lesions in 90% of affected women to enable diagnosis and treatment. In this context, this study reviews trends in the incidence and mortality rates of cervical cancer in Thailand, in addition to providing an up-to-date overview of the causes and necessary risk factors for cervical cancer, as well as reporting on cervical screening and HPV vaccination rates and cervical cancer during the coronavirus disease 2019 (COVID-19) pandemic. This study may prove useful for the formulation of policy aimed at eliminating cervical cancer in Thailand, such as the implementation of a free HPV vaccine service and providing athome kits for cervical screening through clinics and pharmacies. In addition, this review also highlights the need for further research on the effects of the COVID-19 pandemic on cervical cancer screening rates in Thailand.

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Genetic Polymorphism of Glutathione S-transferase and Cervical Cancer Susceptibility in Northeastern Thailand

Cited by 8 publications

References 0 publications

A meta-analysis of XRCC1 single nucleotide polymorphism and susceptibility to gynecological malignancies

A meta-analysis of XRCC1 single nucleotide polymorphism and susceptibility to gynecological malignancies

Frequencies of glutathione S-transferase A1 rs3957357 polymorphism in a Turkish population

Cervical cancer in Thailand: 2023 update

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