Genetic polymorphism of inter-α-trypsin inhibitor (ITI) in the Basque Country (northern Spain)

Abstract

The genetic polymorphism of inter-alpha-trypsin inhibitor (ITI) was analyzed in 2 samples of 554 residents and 303 autochthonous healthy unrelated individuals from the Basque Country (northern Spain), by isoelectric focusing on miniaturized polyacrylamide gels followed by immunoblotting. The allele frequencies were ITI*1 = 0.586, ITI*2 = 0.402 and ITI*3 = 0.012 in residents and ITI*1 = 0.548, ITI*2 = 0.449 and ITI*3 = 0.003 in the autochthonous population. These allele frequencies were compared with those reported in other European populations.