Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China

Jiang, Yi; Zhao, Jie; Jiang, Ting; Ge, Liuqing; Zhou, Feng; Chen, Zhitao; Liu, Yuan; Xia, Bing

doi:10.1111/j.1440-1746.2010.06286.x

Cited by 12 publications

(17 citation statements)

References 29 publications

(47 reference statements)

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“…The 12 studies included 2570 individuals in total, with 1086 IBD patients and 1484 controls [15,16,22,23,24,25,26,27,28,29,30,31]. The detailed results are expressed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Among the 12 studies, the folate concentration in the study by Kuroki et al [24] was excluded because it was detected in red blood cells. Folate and vitamin B12 were detected via chemiluminescence immunoassays in three studies [15,22,28], radioimmunoassays in four studies [23,24,25,30], ELISA in two studies [26,31], a specific immunochemical method in one study [29], and the IMx assay in one study [16]. Three studies did not include the mean age of patients and controls [15,16,23], and one study included the median age of patients and controls [23].…”

Section: Resultsmentioning

confidence: 99%

“…Three studies did not include the mean age of patients and controls [15,16,23], and one study included the median age of patients and controls [23]. Of the 12 included studies, six studies were conducted in Asia [15,22,24,26,28,31], four in Europe [16,23,25,30], one in America [27], and one in Africa [29]. Seven studies investigated the association between UC and serum folate and vitamin B12 concentrations [15,16,22,27,28,30,31]; six studies investigated the association between CD and serum folate and vitamin B12 [15,16,23,27,29,30]; and two studies investigated IBD patients who were not classified by the type of disease [25,26].…”

Section: Resultsmentioning

confidence: 99%

“…The included articles were divided into three groups by the type of disease as follows: only patients with UC (UC group) [15,16,22,27,28,30,31], only patients with CD (CD group) [15,16,23,27,29,30] and patients from studies [25,26] that did not indicate the type of IBD (IBD group). For the UC group (680 UC patients, 1151 controls), the average serum folate concentration was 0.50 ng/mL lower than that of the controls (SMD = −0.50 ng/mL, 95% CI = −0.71, −0.28 ng/mL, I 2 = 63.0%, p = 0.000).…”

Section: Resultsmentioning

confidence: 99%

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Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis

et al. 2017

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Background: Inflammatory bowel disease (IBD) patients may be at risk of vitamin B12 and folate insufficiencies, as these micronutrients are absorbed in the small intestine, which is affected by IBD. However, a consensus has not been reached on the association between IBD and serum folate and vitamin B12 concentrations. Methods: In this study, a comprehensive search of multiple databases was performed to identify studies focused on the association between IBD and serum folate and vitamin B12 concentrations. Studies that compared serum folate and vitamin B12 concentrations between IBD and control patients were selected for inclusion in the meta-analysis. Results: The main outcome was the mean difference in serum folate and vitamin B12 concentrations between IBD and control patients. Our findings indicated that the average serum folate concentration in IBD patients was significantly lower than that in control patients, whereas the mean serum vitamin B12 concentration did not differ between IBD patients and controls. In addition, the average serum folate concentration in patients with ulcerative colitis (UC) but not Crohn’s disease (CD) was significantly lower than that in controls. This meta-analysis identified a significant relationship between low serum folate concentration and IBD. Conclusions: Our findings suggest IBD may be linked with folate deficiency, although the results do not indicate causation. Thus, providing supplements of folate and vitamin B12 to IBD patients may improve their nutritional status and prevent other diseases.

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“…The 12 studies included 2570 individuals in total, with 1086 IBD patients and 1484 controls [15,16,22,23,24,25,26,27,28,29,30,31]. The detailed results are expressed in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis

et al. 2017

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“…Hyperhomocysteinemia (HHcy) is defined as serum homocysteine level >15.0 μmol/L. Over the past decades, many studies have demonstrated that HHcy is pretty prevalent in blood circulation and intestinal mucosa of IBD patients and conducive to the development of IBD [8][9][10] .…”

mentioning

confidence: 99%

An Analysis of Transcobalamin II Gene Polymorphisms and Serum Levels of Homocysteine, Folate and Vitamin B<sub>12</sub> in Chinese Patients with Crohn's Disease

Zheng

Wu²,

Yang³

et al. 2017

Dig Dis

Self Cite

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Objectives: The study aimed to investigate the association of Crohn's disease (CD) with transcobalamin II (TCN2) polymorphisms and serum homocysteine, folate, and vitamin B₁₂ levels. Methods:TCN2 (rs1801198, rs9606756) were genotyped by iMLDR in 389 CD patients and 746 controls. Furthermore, 102 CD patients and 153 controls were randomly selected for examination of serum homocysteine, folate, and vitamin B₁₂ levels by enzymatic cycling assay and chemiluminescence immunoassay, respectively. Results: Mutant allele (G) and genotype (AG + GG) of (rs9606756) were higher in CD patients than in controls (both p < 0.05). So were they in ileocolonic CD patients and stricturing CD patients compared to controls (all p < 0.05). Mutant allele (G) and genotype (CG + GG) of (rs1801198) were more prevalent in stricturing CD patients than in controls (both p < 0.05). Compared to controls, average homocysteine level was enhanced in CD patients (p = 0.003), whereas average folate and vitamin B₁₂ levels were reduced in CD patients (both p < 0.001). The prevalence of hyperhomocysteinemia, folate deficiency, and vitamin B₁₂ deficiency was higher in CD patients than in controls (all p < 0.01). Both folate deficiency and vitamin B₁₂ deficiency were independently related to risk of CD (both p < 0.01). Conclusion:TCN2 (rs1801198, rs9606756) polymorphisms as well as folate deficiency and vitamin B₁₂ deficiency are correlated with CD.

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B12 and Folic Acid

Dharmarajan

Gunturu

2012

Geriatric Gastroenterology

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Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China

Abstract: MTHFR G1793A gene polymorphism, HHcy, folate deficiency and low vitamin B(12) concentration were associated with ulcerative colitis in central China. Our findings demonstrate that the Hcy-related gene and metabolites are involved in pathogenesis of ulcerative colitis.

Cited by 12 publications

References 29 publications

Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis

Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis

An Analysis of Transcobalamin II Gene Polymorphisms and Serum Levels of Homocysteine, Folate and Vitamin B<sub>12</sub> in Chinese Patients with Crohn's Disease

B12 and Folic Acid

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