Genetic polymorphisms and childhood acute lymphoblastic leukemia: GWAS of the ESCALE study (SFCE)

Orsi, Laurent; Rudant, Jérémie; Bonaventure, Audrey; Goujon-Bellec, Stéphanie; Corda, Eve; Evans, Tiffany‐Jane; Petit, Arnaud; Bertrand, Yves; Nelken, Brigitte; Robert, Alain; Gautier, Michel; Sirvent, Nicolas; Chastagner, Pascal; Ducassou, Stéphane; Rialland, Xavier; Hémon, Denis; Milne, Elizabeth; Scott, Rodney J.; Baruchel, André; Clavel, Jacqueline

doi:10.1038/leu.2012.148

Cited by 69 publications

(77 citation statements)

References 12 publications

(18 reference statements)

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“…Most GWAS, until recently, have identified risk loci using only European-origin populations. Variant polymorphisms located within the ARID5B, IKZF1, and CEBPE genes have reported strong risk associations in multiple studies [19][20][21][22][38][39][40]. Our study provides some confirmation of previously discovered genetic markers associated with childhood ALL, which also validated our case-control set for further exploration.…”

Section: Discussionsupporting

confidence: 73%

“…The SNP rs4132601, located in the Ikaros family zinc finger 1 (IKZF1) gene, is associated with increased risk of childhood ALL in multiple studies [19,21,39,40,42]. The Ikaros proteins are known to be involved with lymphocyte development and differentiation [19], and deletions are frequent and associated with unfavorable prognosis in B-cell precursor ALL [19,43].…”

Section: Discussionmentioning

confidence: 99%

“…Genome-wide association studies (GWAS) [19][20][21][22] American populations [8,22], discovering that some markers are universal across races/ethnicities, while others are race/ethnic-specific.…”

Section: Introductionmentioning

confidence: 99%

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Genetic markers in a multi-ethnic sample for childhood acute lymphoblastic leukemia risk

Kennedy¹,

Kamdar²,

Lupo³

et al. 2014

Leukemia & Lymphoma

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Genome-wide association studies have identified multiple risk loci for childhood acute lymphoblastic leukemia (ALL), but mostly in European/White populations despite Hispanics having a greater risk. We re-examined SNPs of known associations with childhood ALL and known HLA region lymphoma risk markers in a multi-ethnic population. Significant associations were found in two ARID5B variants (rs7089424 and rs10821936). We replicated a strong risk association in non-Hispanic White males with rs2395185, a protective marker for lymphoma.Another HLA region marker, rs2647012, showed a risk association among Hispanics only, while a strong protective association was found with rs1048456, a follicular lymphoma risk marker.Our study validated this new case-control sample by confirming genetic markers associated with childhood ALL, and yielded new associations with lymphoma markers. Despite positive results, our study did not provide any clues to why Hispanics have a higher susceptibility to childhood leukemia, suggesting that environmental factors may have a strong contribution.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Genetic markers in a multi-ethnic sample for childhood acute lymphoblastic leukemia risk

Kennedy¹,

Kamdar²,

Lupo³

et al. 2014

Leukemia & Lymphoma

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“…Several genetic diseases and polymorphisms [1], and non-genetic exposures (including H B E B factors. Some factors related to early immune stimulations and environmental exposures (pesticide use at home and, for AL, extremely low frequency electromagnetic fields) are also suspected [2,3].…”

Section: Introductionmentioning

confidence: 99%

Residential exposure to solar ultraviolet radiation and incidence of childhood hematological malignancies in France

Coste¹,

Boniol²,

Marquant³

et al. 2015

Cancer Causes Control

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This version is available at https://strathprints.strath.ac.uk/55336/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the Strathprints administrator: strathprints@strath.ac.ukThe Strathprints institutional repository (https://strathprints.strath.ac.uk) is a digital archive of University of Strathclyde research outputs. It has been developed to disseminate open access research outputs, expose data about those outputs, and enable the management and persistent access to Strathclyde's intellectual output. 1/22Residential exposure to solar ultraviolet radiation and incidence of childhood hematological malignancies in France Abstract 246 WordsPurpose Few studies have investigated the relationship between solar ultraviolet radiation (UV) and childhood hematological malignancies (CHM). This study addresses the associations between residential UV exposure at diagnosis and the incidence of types and subtypes of CHM, by age and gender, in France, over a long period, on the fine scale of the 36,326 Communes that constitute mainland France. Methods The 9,082 cases of acute leukemia (AL) and 3,563 cases of lymphoma diagnosed before the age of 15 years from 1990 to 2009 were provided by the French National Registry of Childhood Hematological Malignancies. The incidence of CHM was calculated by Commune, year, age and gender and expressed as the standardized incidence ratio (SIR). UV data from 1988 to 2007 were extracted from the EUROSUN database. Results The annual daily average UV exposure of the children ranged from 85.5 to 137.8 J/cm 2 . For each additional 25 J/cm 2 there was a significant increase in precursor B-cell acute lymphoblastic leukemia (PBC-ALL) in children aged less than 5 years (SIR: 1.18; 95%CI: 1.10-1.27). Further analysis of PBC-ALL in the young children suggested a better fit of models with a threshold, with the risk increasing above 100 J/cm 2 , for which the SIR was 1.24 (95%CI: 1.14-1.36) for a 25 J/cm² increase. The results remained stable in analyses stratifying by deprivation index or degree of urbanization of the Communes. Conclusion The study suggests that higher residential UV exposure may be positively associated with a higher incidence of PBC-ALL in early childhood.

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“…Therefore, 14 articles including 16 studies were included in the present meta-analysis. Here, eight articles (including 3684 patients and 25085 controls) dealt with SNP rs10994982 (Trevino et al, 2009;Healy et al, 2010;Orsi et al, 2012;Gutierrez-Camino et al, 2013;Linabery et al, 2013;Ross et al, 2013;Xu et al, 2013;Emerenciano et al, 2014). Among the included articles, two articles only reported allele contrasts (Orsi et al, 2012;Xu et al, 2012).…”

Section: Study Characteristicsmentioning

confidence: 99%

Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

Zeng

Wang²,

Cui³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (15), 6211-6217 IntroductionAcute lymphoblastic leukemia (ALL), the most common malignancy in children (Linabery and Ross, 2008;Jiang et al., 2013), is a heterogeneous disease, with respect to its underlying cellular and molecular biology (Papaemmanuil et al., 2009), acquired genetic abnormalities, and social clinical responses to combination chemotherapy (Pui et al., 2004). The mechanisms involved in the etiology of childhood ALL remain obscure. It is hypothesized that both environmental and genetic factors contribute to the initiation of leukemogenesis (Greaves, 2006). Previous genome-wide association studies (GWAS) have implicated the associations of several single nucleotide polymorphisms (SNPs) in the AT-rich interactive domain 5B (ARID5B) gene with childhood ALL (Papaemmanuil et al., 2009;Trevino et al., 2009). Importantly, the ARID5B gene showed specificity for B lineage ALL and B-hyperdiploid subtype (Papaemmanuil et al., 2009;Trevino et al., 2009) ARID5B, the gene encoding the ARID5B protein, which located on chromosome 10q21.2, is one of the common susceptibility loci associated with childhood ALL risk (Papaemmanuil et al., 2009 Abstract Previous genome-wide association studies (GWAS) have implicated several single nucleotide polymorphisms (SNPs) in the AT-rich interactive domain 5B (ARID5B) gene with childhood acute lymphoblastic leukemia (ALL).However, replicated studies reported some inconsistent results in different populations. Using meta-analysis, we here aimed to clarify the nature of the genetic risks contributed by the two polymorphisms (rs10994982, rs7089424) for developing childhood ALL. Through searches of PubMed, EMBASE, and manually searching relevant references, a total of 14 articles with 16 independent studies were included. Odds ratios (ORs) with 95% confidence intervals (95%CI) were calculated to assess the associations. Both SNPs rs10994982 and rs7089424 showed significant associations with childhood ALL risk in all genetic models after Bonferroni correction. Furthermore, subtype analyses of B-lineage ALL provided strong evidence that SNP rs10994982 is highly associated with the risk of developing B-hyperdiploid ALL. These results indicate that SNPs rs10994982 and rs7089424 are indeed significantly associated with increased risk of childhood ALL.

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Genetic polymorphisms and childhood acute lymphoblastic leukemia: GWAS of the ESCALE study (SFCE)

Abstract: Every year, acute lymphoblastic leukaemia (ALL) affects about 400 children aged o15 years in France,

Cited by 69 publications

References 12 publications

Genetic markers in a multi-ethnic sample for childhood acute lymphoblastic leukemia risk

Genetic markers in a multi-ethnic sample for childhood acute lymphoblastic leukemia risk

Residential exposure to solar ultraviolet radiation and incidence of childhood hematological malignancies in France

Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

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