Genetic polymorphisms and endometrial cancer risk

Westin, Shannon N.; Lu, Karen H.; Milam, Michael R.

doi:10.1586/14737140.8.7.1159

Cited by 26 publications

(24 citation statements)

References 69 publications

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“…Genetic polymorphisms in functionally critical genes have been suggested as risk factors for the development of a variety of cancers. Candidate genes may be involved in DNA damage repair, carcinogen metabolism, cell-cycle control, apoptosis, and immune response (Meyer et al, 2008). Particularly important is the anti-cancer adaptive immune response.…”

Section: Discussionmentioning

confidence: 99%

Changes in Median Ages at Death from Selected Cancer Types in Relation to HLA-DRB1/DQB1

An¹,

Fan²,

Liang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The median ages at death from cancers between 1985 and 2005 were calculated to demonstrate that inherent anticancer mechanisms may be a common pathway for different cancers. Seventy-eight patients with gastric, liver and lung cancers, were recruited in the solid cancer group. The leukemia group consisted of 31 patients with three main types of leukemia. The controls were 100 healthy individuals. The samples were typed using an HLA-DR/DQ PCR-SSP typing kit. The results showed that the median ages at death from all causes were 64.7 years in 1985 and 70.1 years in 2005. The range of the median ages at death from all cancers was similar to the corresponding value for deaths attributed to all causes. The frequency of DRB1*03 was 9.6% in the solid cancer group and 3.0% in the control group (p<0.05). The frequency of DRB1*04 in the leukemia group were significantly lower than that of the control (p<0.05). DRB1*13 and DQB1*06 frequencies in the leukemia group were significantly higher than those of the controls (p<0.05). It is suggested that inherent anti-cancer mechanisms may be a common pathway for different cancers and are associated with the immune system and HLA.

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Section: Discussionmentioning

confidence: 99%

Changes in Median Ages at Death from Selected Cancer Types in Relation to HLA-DRB1/DQB1

An¹,

Fan²,

Liang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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show abstract

“…Candidate genes may be involved in DNA damage repair, estrogen metabolism, carcinogen metabolism, cell-cycle control, apoptosis, and steroid receptor activation pathways. 24 In this way, several results have indicated common genetic polymorphisms in Korean women that augment the effects of riskfactor exposure, such as p53, p21, CCND1, ERCC1, and HER-2 genes; the results are summarized in Table 1. [25][26][27][28][29] p53, which is one of the representative tumor suppressor genes, and p21, which is a downstream mediator of p53, were examined by Roh et al 26 They found that the p53 genotypes containing the Pro allele at codon 72 and homozygous carriers of the p21 Ser allele at codon 31 were significantly associated with an increased risk of uterine corpus cancer.…”

Section: Risk Factorsmentioning

confidence: 99%

Current status in the management of uterine corpus cancer in Korea

Jeong

Lee

2010

J Gynecol Oncol

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Uterine corpus cancer has increased in prevalence in Korean women over the last decade. Recently, elegant studies have been reported from many institutes. To improve treatment strategies, a review of our own data is warranted. This work will discuss the risks and prognostic factors for uterine corpus cancer, and the radiologic evaluation, prediction of lymph node metastasis, systematic lymphadenectomy, minimally invasive surgery, ovarian-saving surgery, fertility-sparing treatment, and adjuvant treatment in women with uterine cancer.

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“…At the same time about 2% of all ovarian cases [58] and as high as 8% of young endometrial cancer cases are explained by such germline mutations. [30].…”

Section: Hereditary Non-polyposis Colon Cancer Syndromementioning

confidence: 99%

Screening for gynaecologic cancers in genetically predisposed women

Dreyer

2012

Best Practice & Research Clinical Obstetrics & Gynaecol

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Hereditary breast and ovarian cancer (HBOC) syndrome and hereditary nonpolyposis colon cancer (HNPCC) syndrome are the two most important syndromes responsible for inherited cancers in gynaecology. Genetic testing is available for both these syndromes. BRCA testing is affordable and easy in patients with ancestry where the mutation patterns are known, other population groups need full gene screening. HNPCC can now be diagnosed more frequently with the use of immunohistochemistry.Ovarian cancer risk is high in HBOC syndromes and advanced screening techniques should be used when preventive surgery is not an option. Early detection techniques offer less protection than prophylactic removal, but enable the patient to retain her reproductive organs. Oophorectomy has the advantage of reducing breast cancer risk.In colorectal cancer syndromes the risk for endometrial and ovarian cancer is much elevated. These risks should be recognised and addressed as these diseases are easy to prevent.

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Genetic polymorphisms and endometrial cancer risk

Cited by 26 publications

References 69 publications

Changes in Median Ages at Death from Selected Cancer Types in Relation to HLA-DRB1/DQB1

Changes in Median Ages at Death from Selected Cancer Types in Relation to HLA-DRB1/DQB1

Current status in the management of uterine corpus cancer in Korea

Screening for gynaecologic cancers in genetically predisposed women

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