Genetic Polymorphisms Associated with Overweight and Obesity in Uncontrolled Type 2 Diabetes Mellitus

Kasim, Nor Bahirah; Huri, Hasniza Zaman; Vethakkan, Shireene Ratna; Ibrahim, Luqman; Abdullah, Bashar Mudhaffar

doi:10.2217/bmm-2015-0037

Cited by 39 publications

(26 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Type two diabetes mellitus (T2DM) is discussed a major global epidemic leading to loss health in general population [1]. Although the results of recent studies have been well established that overweigh/ obesity and metabolic syndrome are represented the leading risk factor for T2DM and diabetes-related cardiovascular (CV) complications [2][3][4], the impact of the dysmetabolic states on molecular mechanisms regarding vasculature repair systems and "metabolic memory" is not fully investigated [5][6][7]. By now, endothelial dysfunction (ED) has found a key player in increasing CV risk in overweigh/obese and T2DM subjects [8,9].…”

Section: Reviewmentioning

confidence: 99%

Impaired Immune Phenotype of Endothelial Cell-derived Micro Particles: The Missing Link between Diabetes-related States and Risk of Cardiovascular Complications?

Berezin¹

2016

J Data Mining Genomics Proteomics

View full text Add to dashboard Cite

Type two diabetes mellitus (T2DM) remains a leading contributor to cardiovascular (CV) mortality worldwide. Although obese and metabolic syndrome are discussed key factors contributing a higher risk of T2DM, the exact molecular mechanisms underlying to the progression of dysmetabolic states are still not completely clear. There is large body of evidence regarding endothelial dysfunction as a key player in increasing CV risk and that vascular damage in the dysmetabolic patients might mediate through an imbalance between various populations of micro particle (MP). The short commentary is discussed a role of impaired ratio between apoptotic MPs and activated MPs derived from endothelial cells that was recognized as "impaired phenotype" of endothelial cell-derived MPs. It has considered the causality epigenetic reprogramming, metabolic disorders, inflammation, and oxidative stress in forming of "impaired phenotype" of MPs. The incorporation of measurement of the endothelial cell-derived MP number into a conventional CV risk factor model aimed improving of risk stratification of the dysmetabolic patients with high probability of CV disease is discussed. processing that is essential for phenotype modification, tissue repair, cell death, malignancy, and immunity [14-17].

show abstract

Section: Reviewmentioning

confidence: 99%

Impaired Immune Phenotype of Endothelial Cell-derived Micro Particles: The Missing Link between Diabetes-related States and Risk of Cardiovascular Complications?

Berezin¹

2016

J Data Mining Genomics Proteomics

View full text Add to dashboard Cite

show abstract

“…Therefore, the disruption of Grb14‐mediated homeostasis may be associated with the progression of several physiological disorders. Genetic analyses during the last decade, including genome‐wide association studies, have demonstrated that the GRB14 gene is associated with cancer, obesity, and metabolic diseases such as noninsulin‐dependent and gestational diabetes mellitus …”

Section: Introductionmentioning

confidence: 99%

“…Genetic analyses during the last decade, including genome-wide association studies, have demonstrated that the GRB14 gene is associated with cancer, obesity, and metabolic diseases such as noninsulin-dependent and gestational diabetes mellitus. [11][12][13][14][15][16][17][18] The Grb7 family proteins is composed of several modular signaling domains, including N-terminal polyproline sequences, a Rasassociation domain, a pleckstrin homology (PH) domain, and a Cterminal Src homology-2 (SH2) domain. In addition, Grb7 family proteins contain a unique region termed the between PH and SH2 (BPS) domain 8 or phosphorylated IR-interacting region (PIR).…”

Section: Introductionmentioning

confidence: 99%

Dephosphorylation of clustered phosphoserine residues in human Grb14 by protein phosphatase 1 and its effect on insulin receptor complex formation

Taira

Yoshida

Takemoto

et al. 2019

Journal of Peptide Science

View full text Add to dashboard Cite

The physical interaction of the human growth factor receptor‐bound protein 14 (hGrb14) and the insulin receptor (IR) represses insulin signaling. With respect to the recruiting mechanism of hGrb14 to IR respond to insulin stimulus, our previous reports have suggested that phosphorylation of Ser358, Ser362, and Ser366 in hGrb14 by glycogen synthase kinase‐3 repressed hGrb14–IR complex formation. In this study, we investigated phosphatase‐mediated dephosphorylation of the hGrb14 phosphoserine residues. An in vitro phosphatase assay with hGrb14‐derived synthetic phosphopeptides suggested that protein phosphatase 1 (PP1) is involved in the dephosphorylation of Ser358 and Ser362. Furthermore, coimmunoprecipitation experiments suggested that insulin‐induced hGrb14–IR complex formation was repressed by the substitution of Ser358 or Ser362 with glutamic acid. These findings suggested that phosphate groups on Ser358 and Ser362 in hGrb14 are dephosphorylated by PP1, and the dephosphorylation facilitates hGrb14–IR complex formation.

show abstract

“…Otherwise, GWAS cannot exclude the possibility that some of the excluded SNPs might correlate with PCOS because of rare SNPs and technical errors. To date, many LEPR polymorphisms have been identified in genetic association studies, including Lys109Arg, Gln223Arg, Ser343Ser, Lys656Asn and Pro1019Pro [6,7]. Among them, as two nonsynonymous SNPs located in the LEPR gene polymorphism and plasma soluble leptin receptor levels are associated with polycystic ovary syndrome in Han Chinese women Xiaoyu exon 2 and exon 4, respectively, Lys109Arg (rs1137100) and Gln223Arg (rs1137101) drew our attention.…”

mentioning

confidence: 99%

“…Among them, as two nonsynonymous SNPs located in the LEPR gene polymorphism and plasma soluble leptin receptor levels are associated with polycystic ovary syndrome in Han Chinese women Xiaoyu exon 2 and exon 4, respectively, Lys109Arg (rs1137100) and Gln223Arg (rs1137101) drew our attention. The reports on these two LEPR SNPs suggested their relations with metabolic diseases such as obesity, IR, dyslipidemia, hypertension and Type 2 diabetes [6][7][8]. However, the relationship between them and PCOS needs to be further determined even though two studies have studied the Gln223Arg (rs1137101) polymorphism in Han Chinese PCOS patients, both with small sample sizes [9,10].…”

mentioning

confidence: 99%

LEPR Gene Polymorphism and Plasma Soluble Leptin Receptor Levels are Associated with Polycystic Ovary Syndrome in Han Chinese Women

Gao

et al. 2017

Per. Med.

View full text Add to dashboard Cite

Aim:To investigate the association of LEPR polymorphisms and plasma leptin and soluble leptin receptor (sOB-R) levels with polycystic ovary syndrome (PCOS) in Chinese women. Patients & methods: LEPR Lys109Arg (rs1137100) and Gln223Arg (rs1137101) polymorphisms of PCOS patients and the controls were genotyped. Plasma leptin and sOB-R levels of two groups were measured. Results: The genotypic distributions of Lys109Arg (rs1137100) differed between the PCOS and control groups. Plasma sOB-R levels increased significantly in PCOS patients and were associated with PCOS independent of BMI. Furthermore, luteinizing hormone, triglyceride and fasting blood glucose correlated significantly to PCOS patients' sOB-R levels. Conclusion: LEPR Lys109Arg (rs1137100) was associated with PCOS susceptibility and genotype AA was deduced to be a protective factor for PCOS; sOB-R levels might be recognized as a new indicator for the severity of PCOS.

show abstract

Genetic Polymorphisms Associated with Overweight and Obesity in Uncontrolled Type 2 Diabetes Mellitus

Cited by 39 publications

References 78 publications

Impaired Immune Phenotype of Endothelial Cell-derived Micro Particles: The Missing Link between Diabetes-related States and Risk of Cardiovascular Complications?

Impaired Immune Phenotype of Endothelial Cell-derived Micro Particles: The Missing Link between Diabetes-related States and Risk of Cardiovascular Complications?

Dephosphorylation of clustered phosphoserine residues in human Grb14 by protein phosphatase 1 and its effect on insulin receptor complex formation

LEPR Gene Polymorphism and Plasma Soluble Leptin Receptor Levels are Associated with Polycystic Ovary Syndrome in Han Chinese Women

Contact Info

Product

Resources

About